DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FES and PIN3

DIOPT Version :9

Sequence 1:	NP_001996.1	Gene:	FES / 2242	HGNCID:	3657	Length:	822	Species:	Homo sapiens
Sequence 2:	NP_015480.1	Gene:	PIN3 / 856277	SGDID:	S000006358	Length:	215	Species:	Saccharomyces cerevisiae

Alignment Length:	144	Identity:	33/144 - (22%)
Similarity:	50/144 - (34%)	Gaps:	34/144 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    10 PQGHGVLQQMQEAELRLLEGMR-KWM------------AQRVKSDREYAGLLHHMSLQDSGGQSR 61
            ||..|.|......:::|||.:. :|.            |..||.           :...|.|.|.
Yeast    67 PQQDGDLGLKPGDKVQLLEKLSPEWYKGSCNGRTGIFPANYVKP-----------AFSGSNGPSN 120

Human    62 AISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQWQQLQQE 126
            ...|....:|...:|.:|....|...:|      ..|....:...:.:||.::....|.||.||:
Yeast   121 LPPPPQYKAQELQQIPTQNSAASSYQQQ------PFPPPSTNYYQQPQQQPQQAPPPQQQQQQQQ 179

Human   127 LTKTHSQDIEKLKS 140
            ...:||.    |||
Yeast   180 HQSSHSH----LKS 189

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FES	NP_001996.1	Important for interaction with membranes containing phosphoinositides	1..300		33/144 (23%)
		F-BAR_Fes	7..239	CDD:153369	33/144 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	394..421
		SH2_Fps_family	453..537	CDD:198224
		Pkinase_Tyr	561..814	CDD:285015
		PTKc_Fes	564..815	CDD:270667
PIN3	NP_015480.1	SH3	58..110	CDD:418401	10/42 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000