DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FES and TPK2

DIOPT Version :9

Sequence 1:	NP_001996.1	Gene:	FES / 2242	HGNCID:	3657	Length:	822	Species:	Homo sapiens
Sequence 2:	NP_015121.1	Gene:	TPK2 / 855898	SGDID:	S000006124	Length:	380	Species:	Saccharomyces cerevisiae

Alignment Length:	309	Identity:	82/309 - (26%)
Similarity:	136/309 - (44%)	Gaps:	52/309 - (16%)

- Green bases have known domain annotations that are detailed below.

Human   530 LLSTQQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE 594
            ||::|.|  :||      .|.|.|:.|:  |..:...:|.|:||.|...|...:....|:|..::
Yeast    49 LLTSQLP--QKS------LVSKGKYTLH--DFQIMRTLGTGSFGRVHLVRSVHNGRYYAIKVLKK 103

Human   595 TLPPDLKAKFLQ----EARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARL 655
              ...:|.|.::    |.|:||...||.::|:.|.....:.|::||:.::||:..:.|| :..|.
Yeast   104 --QQVVKMKQVEHTNDERRMLKLVEHPFLIRMWGTFQDARNIFMVMDYIEGGELFSLLR-KSQRF 165

Human   656 RVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLR 720
            ..........:....:|||.:...|:|||...|.|:.....:||:|||.::|..
Yeast   166 PNPVAKFYAAEVILALEYLHAHNIIYRDLKPENILLDRNGHIKITDFGFAKEVQ----------- 219

Human   721 QVPVKWT--------APEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGG 777
              .|.||        |||.:....|:...|.||.|:|::|..: |.:|:.:.:..:|.|.:.:|.
Yeast   220 --TVTWTLCGTPDYIAPEVITTKPYNKSVDWWSLGVLIYEMLA-GYTPFYDTTPMKTYEKILQGK 281

Human   778 RLPCPELCPDAVFRLMEQCWA--------YEPGQR-----PSFSTIYQE 813
            .:..|...||.|..|.:...|        .:.|.|     |.||.:..|
Yeast   282 VVYPPYFHPDVVDLLSKLITADLTRRIGNLQSGSRDIKAHPWFSEVVWE 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FES	NP_001996.1	Important for interaction with membranes containing phosphoinositides	1..300
		F-BAR_Fes	7..239	CDD:153369
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	394..421
		SH2_Fps_family	453..537	CDD:198224	3/6 (50%)
		Pkinase_Tyr	561..814	CDD:285015	71/278 (26%)
		PTKc_Fes	564..815	CDD:270667	71/275 (26%)
TPK2	NP_015121.1	STKc_PKA_like	69..358	CDD:270732	72/279 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910