DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FES and KIN1

DIOPT Version :9

Sequence 1:	NP_001996.1	Gene:	FES / 2242	HGNCID:	3657	Length:	822	Species:	Homo sapiens
Sequence 2:	NP_010407.1	Gene:	KIN1 / 851700	SGDID:	S000002529	Length:	1064	Species:	Saccharomyces cerevisiae

Alignment Length:	450	Identity:	98/450 - (21%)
Similarity:	179/450 - (39%)	Gaps:	101/450 - (22%)

- Green bases have known domain annotations that are detailed below.

Human   403 QDDRHSTSSSEQEREGGRTPTLEILKSHISGIFRPKFSLPPPLQLI---PEVQKPLHEQLWYHGA 464
            |||.:|.|:|...                    :|....|..|:::   |:.|:..:..|
Yeast    18 QDDGNSESNSMHT--------------------QPSTMAPATLRMMGKSPQQQQQQNTPL----- 57

Human   465 IPRAEVAELLVHSGDFLVRESQGKQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDH 529
            :|.|::.  ..::|:....|.:.:|                       ..|||:...:.|
Yeast    58 MPPADIK--YANNGNSHQAEQKERQ-----------------------VELEGKSRENAP----- 92

Human   530 LLSTQQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSC-- 592
                :...|.:|.|...:.:||.....:..|....|.:|.|:.|:|...:.|..|.:.|||..
Yeast    93 ----KPNTTSQSRVSSSQGMPKQFHRKSLGDWEFVETVGAGSMGKVKLAKHRYTNEVCAVKIVNR 153

Human   593 --------RETLPP------------DLKAKFLQEARILKQYS------HPNIVRLIGVCTQKQP 631
                    .:.|||            .|:.:..::.|.:::.|      ||:|.||..:||....
Yeast   154 ATKAFLHKEQMLPPPKNEQDVLERQKKLEKEISRDKRTIREASLGQILYHPHICRLFEMCTLSNH 218

Human   632 IYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNV 696
            .|::.|.|.||..|.::...|: :|.....:.....|:.:.||.:...:||||...|.::::.:.
Yeast   219 FYMLFEYVSGGQLLDYIIQHGS-IREHQARKFARGIASALIYLHANNIVHRDLKIENIMISDSSE 282

Human   697 LKISDFGMSR--EEADGVYAASGGLRQVPVKWTAPEALNYGRYSS-ESDVWSFGILLWETFSLGA 758
            :||.|||:|.  :....::...|.|     .:.|||.|....|:. |.||||||::|: ....|.
Yeast   283 IKIIDFGLSNIYDSRKQLHTFCGSL-----YFAAPELLKANPYTGPEVDVWSFGVVLF-VLVCGK 341

Human   759 SPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIR 818
            .|:.:.::....|.: |.|::..|:.....|..|:.:....:|.:|.:...:.:....:|
Yeast   342 VPFDDENSSVLHEKI-KQGKVEYPQHLSIEVISLLSKMLVVDPKRRATLKQVVEHHWMVR 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FES	NP_001996.1	Important for interaction with membranes containing phosphoinositides	1..300
		F-BAR_Fes	7..239	CDD:153369
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	394..421		6/17 (35%)
		SH2_Fps_family	453..537	CDD:198224	10/83 (12%)
		Pkinase_Tyr	561..814	CDD:285015	70/283 (25%)
		PTKc_Fes	564..815	CDD:270667	70/281 (25%)
KIN1	NP_010407.1	STKc_Kin1_2	118..398	CDD:270979	71/287 (25%)
KIN1	NP_010407.1	MARK_C_like	890..1062	CDD:213377
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910