DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FES and CDC15

DIOPT Version :9

Sequence 1:	NP_001996.1	Gene:	FES / 2242	HGNCID:	3657	Length:	822	Species:	Homo sapiens
Sequence 2:	NP_009411.2	Gene:	CDC15 / 851274	SGDID:	S000000072	Length:	974	Species:	Saccharomyces cerevisiae

Alignment Length:	262	Identity:	71/262 - (27%)
Similarity:	115/262 - (43%)	Gaps:	14/262 - (5%)

- Green bases have known domain annotations that are detailed below.

Human   545 LHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEAR 609
            :.||  .:|.|..|    |.:.||||::|.|:....:..:.:||:|........:|. ..:.|..
Yeast    15 IQRA--SEKSVQYH----LKQVIGRGSYGVVYKAINKHTDQVVAIKEVVYENDEELN-DIMAEIS 72

Human   610 ILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYL 674
            :||..:|.|||:..|...:...:||::|....|.....:......|........|.....|::||
Yeast    73 LLKNLNHNNIVKYHGFIRKSYELYILLEYCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYL 137

Human   675 ESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSS 739
            ..:..||||:.|.|.|::..|.:|::|||:|..........:|.|     .|.|||.|.....|:
Yeast   138 HGEGVIHRDIKAANILLSADNTVKLADFGVSTIVNSSALTLAGTL-----NWMAPEILGNRGAST 197

Human   740 ESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQR 804
            .||:||.|..:.|..:.. .||.||::......||.....| |....:.:...:.:|:.....:|
Yeast   198 LSDIWSLGATVVEMLTKN-PPYHNLTDANIYYAVENDTYYP-PSSFSEPLKDFLSKCFVKNMYKR 260

Human   805 PS 806
            |:
Yeast   261 PT 262

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FES	NP_001996.1	Important for interaction with membranes containing phosphoinositides	1..300
		F-BAR_Fes	7..239	CDD:153369
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	394..421
		SH2_Fps_family	453..537	CDD:198224
		Pkinase_Tyr	561..814	CDD:285015	66/246 (27%)
		PTKc_Fes	564..815	CDD:270667	65/243 (27%)
CDC15	NP_009411.2	PKc_like	24..272	CDD:419665	67/251 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910