DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FES and FER

DIOPT Version :9

Sequence 1:	NP_001996.1	Gene:	FES / 2242	HGNCID:	3657	Length:	822	Species:	Homo sapiens
Sequence 2:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster

Alignment Length:	1332	Identity:	344/1332 - (25%)
Similarity:	501/1332 - (37%)	Gaps:	530/1332 - (39%)

- Green bases have known domain annotations that are detailed below.

Human     1 MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQSRAIS- 64
            |||||.|.|...|..|...|:|||||:|.|::.:..:.|.|:|||     :||.....|...|.
  Fly     1 MGFSSALQSRAAHEALIVRQDAELRLMETMKRSIQMKAKCDKEYA-----ISLTAVAQQGLKIDR 60

Human    65 ----PDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQWQQLQQ 125
                ..|.||:||.....:.:..::..:.:||.|.. ...||:.|.:::::.||.|.|:..::..
  Fly    61 ADEMQGSLISKSWRSYMDELDHQAKQFKFNAEQLEV-VCDKLTHLSQDKRKARKAYQEEHAKIAA 124

Human   126 ELTKTHSQDIEKLKSQYRALARDSAQAKRKYQE------ASKDKDRDKAKDKYVRSLWKLFAHHN 184
            .|.....:.:.| ||:|:.........:.:::|      :...:..|..:|||.::..||...||
  Fly   125 RLNHLTDEVVRK-KSEYQKHLEGYKALRTRFEENYIKAPSRSGRKLDDVRDKYQKACRKLHLTHN 188

Human   185 RYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHREMA 249
            .|||.:..|....:....:||||||...|.:.|....:.:.||||..:...|..|:...|.:.:.
  Fly   189 EYVLSITEAIEVEKDFRNVLLPGLLEHQQSVQESFILLWRNILQEAAQYGDLTADKYKEIQKRID 253

Human   250 AAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVES--------- 305
            .....|.|..||..|..:|.::|..|....|||:|:::    .||:||.:.|||::
  Fly   254 TVIGSINPTEEYGEFTEKYKTSPTTPLLFQFDETLIQD----IPGKLQSSTLTVDNLTVDWLRNR 314

Human   306 ------------------VQHT------------------------------------------- 309
                              ::|.
  Fly   315 LQELEGAVRDCQEKQMKMIEHVNGGSPVANGSIISNGSNTSNGIQSNKDSLCRQSKDLNALRCQE 379

Human   310 ---------------------LTSVTDE---------------------------LAVATEMVFR 326
                                 |.|..|:                           |.:..|:: |
  Fly   380 KQKQKLVDMIKCALNEVGCEELPSGCDDDLTLEQNFIENGYNNEQQRSNSTSSPGLGIMNELM-R 443

Human   327 RQEMVTQLQQELRNEEENTHP-----------------RERVQLLGKRQVLQEA----------- 363
            |..::|.|:...|:.:..:.|                 :.|.|.||...|:::.
  Fly   444 RGGVLTLLRGRGRHFKRKSTPQPATPMTRSRQGRFNKLQPRSQSLGSLSVIRDGNGPSPARYEPI 508

Human   364 -------------------------------------------------------LQGLQVAL-- 371
                                                                   |..|..|:
  Fly   509 TNHRLRQAASVHYLGEEIATSSTNPPDLTRLRRTQCSMLCLGEDEEPVVLASPAPLTQLTAAVLT 573

Human   372 ------------------------CSQAKLQAQQELLQTKLEHLGP-----------GEPPPVL- 400
                                    |...::|.::|.::.::....|           .|...||
  Fly   574 NTNNNHIYADLELDKKKDTSPSPECKGEQIQPKKEQIRIEINQTAPQNSIDAHLDRIDELNRVLD 638

Human   401 -----LLQ--DD--------------------------RHSTSSSE------------------- 413
                 .||  ||                          |.|:||||
  Fly   639 DRLKRTLQPSDDVNAIESAEENHIQTRKLAKDPDSQTKRSSSSSSECRSSKDTSHSKKRSLSFSQ 703

Human   414 --------QEREGGRTPTLEILKSHI------------------SGIFRP--------------- 437
                    ..:|..::|.:.:.|:||                  ||...|
  Fly   704 KSISNIFSNLKEFSKSPLVRMGKNHILNEEQDAKRTQPSQHHHSSGSDCPTNSSSSSSNNNNNNK 768

Human   438 ---------------------------------------KFSLP--------------------- 442
                                                   ||.:|
  Fly   769 NTSSNSNHSASQSTIITSTITTTITTTTTTTPSKENSRLKFKVPKIQKKSKAIRNTFRSKLLNFQ 833

Human   443 ----------------------------------------------PPL---QLIPEVQ------ 452
                                                          ||.   .:.|.||
  Fly   834 LKRSKPCKQCTKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQFCNCPPAGQKPVKPSVQISGHKD 898

Human   453 ------------------------------------------------------KPLHEQLWYHG 463
                                                                  :||:|:.|:||
  Fly   899 HPFESSSGELDENSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSLAASISLSTNRPLYEEEWFHG 963

Human   464 AIPRAEVAELLVHSGDFLVRESQGKQE--YVLSVLWDGLPRHFIIQSL-DNLYRLEGEGFPSIPL 525
            .:||.||..||.:.|||||||:...:|  .||||.|:| .:|||:|:. :..:|.||..|.||..
  Fly   964 VLPREEVVRLLNNDGDFLVRETIRNEESQIVLSVCWNG-HKHFIVQTTGEGNFRFEGPPFASIQE 1027

Human   526 LIDHLLSTQQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVK 590
            ||.|...::.|:|.|||.:|.|.|.:::|.|:::|:||.|:|||||||:|:..:|::....||||
  Fly  1028 LIMHQYHSELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVK 1092

Human   591 SCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARL 655
            :||.|||.:.|.|||||.||||||.|||||:|||:|.|||||.||||||.||..||:||.....|
  Fly  1093 TCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGL 1157

Human   656 RVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLR 720
            ..:..:.|..||||||.|||||.|||||||||||||..::.:|||||||||||.:  |..|.|::
  Fly  1158 TTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSREEEE--YIVSDGMK 1220

Human   721 QVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELC 785
            |:|||||||||||:|:|:|..||||:|||:||.||.|.:||..::|.:.||.::.|.|:|.|:..
  Fly  1221 QIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKST 1285

Human   786 PDAVFRLMEQCWAYEPGQRPSFSTIYQELQSI 817
            |:.::|||.||||.:...||.|..||..:.::
  Fly  1286 PEEMYRLMLQCWAADAESRPHFDEIYNVVDAL 1317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FES	NP_001996.1	Important for interaction with membranes containing phosphoinositides	1..300		90/309 (29%)
		F-BAR_Fes	7..239	CDD:153369	67/242 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	394..421		14/87 (16%)
		SH2_Fps_family	453..537	CDD:198224	39/86 (45%)
		Pkinase_Tyr	561..814	CDD:285015	148/252 (59%)
		PTKc_Fes	564..815	CDD:270667	146/250 (58%)
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341	67/242 (28%)
		SH2_Fps_family	953..1039	CDD:198224	39/86 (45%)
		TyrKc	1063..1311	CDD:197581	146/249 (59%)
		PTKc_Fes_like	1067..1315	CDD:270637	146/249 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	310	1.000	Domainoid score	I1327
eggNOG	1	0.900	-	-		E2759_KOG0194
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	552	1.000	Inparanoid score	I1129
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D255116at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		otm42064
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	LDO	PTHR24418
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3894
SonicParanoid	1	1.000	-	-		X1749
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.860