DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FES and Fes

DIOPT Version :9

Sequence 1:	NP_001996.1	Gene:	FES / 2242	HGNCID:	3657	Length:	822	Species:	Homo sapiens
Sequence 2:	NP_001101958.1	Gene:	Fes / 361597	RGDID:	1564385	Length:	822	Species:	Rattus norvegicus

Alignment Length:	822	Identity:	752/822 - (91%)
Similarity:	787/822 - (95%)	Gaps:	0/822 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQSRAISP 65
            ||||||||||||||.:||||||||||||||||||||||||||||||||||||||||||||.:..|
  Rat     1 MGFSSELCSPQGHGAVQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQSWSSGP 65

Human    66 DSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQWQQLQQELTKT 130
            |||:||||||||||||.|||:|||||||||||||||||:||||||.|||||:|||||||||||||
  Rat    66 DSPVSQSWAEITSQTENLSRVLRQHAEDLNSGPLSKLSVLIRERQHLRKTYNEQWQQLQQELTKT 130

Human   131 HSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRYVLGVRAAQL 195
            |||||||||||||.|.||||||:||||||||||||||||||||||||||||||||||||||||||
  Rat   131 HSQDIEKLKSQYRTLTRDSAQARRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRYVLGVRAAQL 195

Human   196 HHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHREMAAAAARIQPEAE 260
            ||||:||.:|||||:||||||||||.|||:||||||||||||||:|.:||||:||||||||||.|
  Rat   196 HHQHYHQFMLPGLLQSLQDLHEEMAGILKDILQEYLEISSLVQDDVASIHRELAAAAARIQPEFE 260

Human   261 YQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESVQHTLTSVTDELAVATEMVF 325
            |.|||||||||||||||||||.|||||||.||||:|||||||:||||||||||||||||||:.|.
  Rat   261 YLGFLRQYGSAPDVPPCVTFDVSLLEEGEQLEPGDLQLNELTLESVQHTLTSVTDELAVATKEVL 325

Human   326 RRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQGLQVALCSQAKLQAQQELLQTKLEH 390
            .|||||:|||:||:.||:||||||||||||||||||||:||||||||:|.||||||||||:|:|.
  Rat   326 SRQEMVSQLQRELQCEEQNTHPRERVQLLGKRQVLQEAMQGLQVALCNQDKLQAQQELLQSKMEQ 390

Human   391 LGPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEILKSHISGIFRPKFSLPPPLQLIPEVQKPL 455
            ||.||||.|.|||||||||||:||||:|||||||||:|||.|||||||||:||||||:|||||||
  Rat   391 LGTGEPPAVPLLQDDRHSTSSTEQERDGGRTPTLEIIKSHFSGIFRPKFSIPPPLQLVPEVQKPL 455

Human   456 HEQLWYHGAIPRAEVAELLVHSGDFLVRESQGKQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGF 520
            |||||||||||||||||||.||||||||||||||||||||||||.||||||||.||||||||:||
  Rat   456 HEQLWYHGAIPRAEVAELLTHSGDFLVRESQGKQEYVLSVLWDGQPRHFIIQSSDNLYRLEGDGF 520

Human   521 PSIPLLIDHLLSTQQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNT 585
            |||||||.||||:||||||||||||.||||||||||.||||||||||||||||||||||||||||
  Rat   521 PSIPLLITHLLSSQQPLTKKSGVVLFRAVPKDKWVLKHEDLVLGEQIGRGNFGEVFSGRLRADNT 585

Human   586 LVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT 650
            .||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||
  Rat   586 PVAVKSCRETLPPDLKAKFLQEARILKQYNHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT 650

Human   651 EGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAA 715
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||
  Rat   651 EGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGIYAA 715

Human   716 SGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLP 780
            |.|||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||.|||
  Rat   716 SAGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLTNQQTREFVEKGHRLP 780

Human   781 CPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR 822
            ||||||||||||||||||||||||||||||.|||||||||||
  Rat   781 CPELCPDAVFRLMEQCWAYEPGQRPSFSTICQELQSIRKRHR 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FES	NP_001996.1	Important for interaction with membranes containing phosphoinositides	1..300		268/298 (90%)
		F-BAR_Fes	7..239	CDD:153369	210/231 (91%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	394..421		22/26 (85%)
		SH2_Fps_family	453..537	CDD:198224	77/83 (93%)
		Pkinase_Tyr	561..814	CDD:285015	245/252 (97%)
		PTKc_Fes	564..815	CDD:270667	243/250 (97%)
Fes	NP_001101958.1	F-BAR_Fes	7..239	CDD:153369	210/231 (91%)
		SH2_Fps_family	453..537	CDD:198224	77/83 (93%)
		Pkinase_Tyr	561..814	CDD:285015	245/252 (97%)
		PKc_like	564..815	CDD:304357	243/250 (97%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83697555
Domainoid	1	1.000	810	1.000	Domainoid score	I2582
eggNOG	1	0.900	-	-		E2759_KOG0194
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37563
Inparanoid	1	1.050	1515	1.000	Inparanoid score	I2689
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG47024
OrthoDB	1	1.010	-	-		D19495at314146
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		oto130175
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	LDO	PTHR24418
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1749
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	17.270