DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FES and kin-14

DIOPT Version :9

Sequence 1:	NP_001996.1	Gene:	FES / 2242	HGNCID:	3657	Length:	822	Species:	Homo sapiens
Sequence 2:	NP_492004.1	Gene:	kin-14 / 172440	WormBaseID:	WBGene00002198	Length:	418	Species:	Caenorhabditis elegans

Alignment Length:	438	Identity:	150/438 - (34%)
Similarity:	231/438 - (52%)	Gaps:	67/438 - (15%)

- Green bases have known domain annotations that are detailed below.

Human   404 DDRHSTSSSEQEREGGRTPTLEILKSHISGIFRPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRA 468
            |...||||..:..:|                                 ||..:|  |:||.:.|.
Worm     9 DSSSSTSSMTENSDG---------------------------------QKQNNE--WFHGVLQRQ 38

Human   469 EVAELLVHSGDFLVRESQ--GKQEYVLSVLWDGLPRHFIIQS--LDNLYRLEGEGFPSIPLLIDH 529
            :..||||..|.||:|.|:  ||...:|||..||...:..:.|  .:|.: .||....||..|:..
Worm    39 DADELLVKPGSFLLRASEVHGKMSMILSVRHDGKLHNIAVNSDTGENFW-FEGHREKSIDQLVQW 102

Human   530 LLSTQQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEV------FSGRLRADNTLVA 588
            .::|..|:||.|||.|...:.|..|:::||:::..:::|.|.||||      ..||    ....|
Worm   103 HMTTSTPITKTSGVKLKYPIGKADWIISHENVIFIKKLGEGAFGEVSLAECEIGGR----KVETA 163

Human   589 VKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLI-----------GVCTQKQPIYIVMELVQGG 642
            ||:.|..:..|.:|.|::|||::::||||:|||:|           |:.....|:.||||:...|
Worm   164 VKTMRCQMTRDTRAAFMKEARLMRKYSHPHIVRIIGKIIVKHLPKVGLAVDAHPLMIVMEMCPHG 228

Human   643 DFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSRE 707
            ..|:|||....:..:...|:...::|.|:.|||.|.|:|||:||||||::..:.:||||||:|.:
Worm   229 SLLSFLRKNKGKTTLSERLRFCIESADGLAYLEKKQCLHRDIAARNCLLSITDQIKISDFGLSDD 293

Human   708 EADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTRE- 771
            :...::  ...|.:|||||.|||.:....||.:||||:||:|:||.::.||.|||.::|..||.
Worm   294 KRTEMH--DDTLDKVPVKWLAPEVMQDKLYSLKSDVWAFGVLMWEIYADGADPYPGMTNLVTRAK 356

Human   772 -FVEKGGRLPCPELCPDAVFRL-MEQCWAYEPGQRPSFSTIYQELQSI 817
             |.: ..|:..||..|..:..: ::||||..|..|.:..|::.:|:.:
Worm   357 IFCD-DYRMTFPETTPPTISEIALKQCWAKLPSDRATMKTVHHKLKDL 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FES	NP_001996.1	Important for interaction with membranes containing phosphoinositides	1..300
		F-BAR_Fes	7..239	CDD:153369
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	394..421		6/16 (38%)
		SH2_Fps_family	453..537	CDD:198224	30/87 (34%)
		Pkinase_Tyr	561..814	CDD:285015	101/272 (37%)
		PTKc_Fes	564..815	CDD:270667	101/270 (37%)
kin-14	NP_492004.1	SH2_Fps_family	26..110	CDD:198224	29/86 (34%)
		Pkinase_Tyr	134..400	CDD:285015	101/272 (37%)
		PTKc	138..401	CDD:270623	101/269 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3720
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D255116at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		mtm5010
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1749
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.770