Protein Alignment FES and Fes

DIOPT Version :10

• Sequence 1: NP_001996.1
• Gene: FES / 2242
• HGNCID: 3657
• Length: 822
• Species: Homo sapiens
• Sequence 2: NP_034324.2
• Gene: Fes / 14159
• MGIID: 95514
• Length: 822
• Species: Mus musculus
• Alignment Length: 822
• Identity: 745/822 - (90%)
• Similarity: 783/822 - (95%)
• Gaps: 0/822 - (0%)

Human     1 MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQSRAISP 65
            ||||||||||||||.:||||||||||||||||||||||||||||||||||||||||||||.:..|
Mouse     1 MGFSSELCSPQGHGAVQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQSWSSGP 65

Human    66 DSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQWQQLQQELTKT 130
            |||:||||||||||||.|||:|||||||||||||||||:||||||.|||||:|||||||||||||
Mouse    66 DSPVSQSWAEITSQTENLSRVLRQHAEDLNSGPLSKLSVLIRERQHLRKTYNEQWQQLQQELTKT 130

Human   131 HSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRYVLGVRAAQL 195
            |||||||||:|||.|.|||.||:||||||||||||||||||||||||||||||||||||||||||
Mouse   131 HSQDIEKLKTQYRTLVRDSTQARRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRYVLGVRAAQL 195

Human   196 HHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHREMAAAAARIQPEAE 260
            ||.|||:.:|||||:||||||||||.|||:||||||||||||||:|.:||||:||||||||||.|
Mouse   196 HHHHHHRFMLPGLLQSLQDLHEEMAGILKDILQEYLEISSLVQDDVASIHRELAAAAARIQPEFE 260

Human   261 YQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESVQHTLTSVTDELAVATEMVF 325
            |.||||||||.|||||||||||||||:||.||||||||||||:||||||||||||||||||:.|.
Mouse   261 YLGFLRQYGSTPDVPPCVTFDESLLEDGEQLEPGELQLNELTLESVQHTLTSVTDELAVATKEVL 325

Human   326 RRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQGLQVALCSQAKLQAQQELLQTKLEH 390
            .|||||:|||:||::||:|||||||||||.|||:||||:||||:|||||.||||||||||:|:|.
Mouse   326 SRQEMVSQLQRELQSEEQNTHPRERVQLLSKRQMLQEAIQGLQIALCSQDKLQAQQELLQSKMEQ 390

Human   391 LGPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEILKSHISGIFRPKFSLPPPLQLIPEVQKPL 455
            ||.||||.|.|||||||||||:||||||||||||||||||.|||||||||:||||||:|||||||
Mouse   391 LGTGEPPAVPLLQDDRHSTSSTEQEREGGRTPTLEILKSHFSGIFRPKFSIPPPLQLVPEVQKPL 455

Human   456 HEQLWYHGAIPRAEVAELLVHSGDFLVRESQGKQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGF 520
            :||||||||||||||||||.||||||||||||||||||||:|||.||||||||.||||||||:||
Mouse   456 YEQLWYHGAIPRAEVAELLTHSGDFLVRESQGKQEYVLSVMWDGQPRHFIIQSSDNLYRLEGDGF 520

Human   521 PSIPLLIDHLLSTQQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNT 585
            |||||||.||||:||||||||||||.||||||||||.||||||||||||||||||||||||||||
Mouse   521 PSIPLLITHLLSSQQPLTKKSGVVLFRAVPKDKWVLKHEDLVLGEQIGRGNFGEVFSGRLRADNT 585

Human   586 LVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT 650
            .||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||
Mouse   586 PVAVKSCRETLPPDLKAKFLQEARILKQYNHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT 650

Human   651 EGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAA 715
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||
Mouse   651 EGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGIYAA 715

Human   716 SGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLP 780
            |.|||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||.|||
Mouse   716 SAGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLTNQQTREFVEKGHRLP 780

Human   781 CPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR 822
            ||||||||||||||||||||||||||||.|.|||.|||||||
Mouse   781 CPELCPDAVFRLMEQCWAYEPGQRPSFSIICQELHSIRKRHR 822

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FES	NP_001996.1	Important for interaction with membranes containing phosphoinositides	1..300		265/298 (89%)
		F-BAR_Fes	7..239	CDD:153369	207/231 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	394..421		23/26 (88%)
		SH2_Fps_family	453..537	CDD:198224	75/83 (90%)
		PTKc_Fes	564..815	CDD:270667	242/250 (97%)
Fes	NP_034324.2	Important for interaction with membranes containing phosphoinositides. /evidence=ECO:0000250	1..300		265/298 (89%)
		F-BAR_Fes	7..239	CDD:153369	207/231 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	392..420		23/27 (85%)
		SH2_Fps_family	453..537	CDD:198224	75/83 (90%)
		Protein Kinases, catalytic domain	564..814	CDD:473864	241/249 (97%)