DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FES and fes

DIOPT Version :9

Sequence 1:	NP_001996.1	Gene:	FES / 2242	HGNCID:	3657	Length:	822	Species:	Homo sapiens
Sequence 2:	XP_002932286.2	Gene:	fes / 100489191	XenbaseID:	XB-GENE-6067138	Length:	822	Species:	Xenopus tropicalis

Alignment Length:	826	Identity:	540/826 - (65%)
Similarity:	663/826 - (80%)	Gaps:	8/826 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQ----DSGGQSR 61
            |||:.||..|.|||.|.::|:.||||:|.|:|...||.|||:||:.:|||||:|    |......
Frog     1 MGFAEELQCPNGHGALLRLQDVELRLMETMKKCFLQRAKSDKEYSNMLHHMSVQVDKLDHSPTPG 65

Human    62 AISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQWQQLQQE 126
            .....|.:::|||.:.||||.||::||:|:||||||||:||::||||:|||:|:||||||.|.|:
Frog    66 LSEYTSQLNESWATLVSQTENLSQILRKHSEDLNSGPLNKLTILIREKQQLKKSYSEQWQLLNQD 130

Human   127 LTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRYVLGVR 191
            ..||..||||||:||||:..:::.|:|||||||.:||||||||:|||::.|||.|.||:|||.|:
Frog   131 YIKTTQQDIEKLRSQYRSQVKETLQSKRKYQEACRDKDRDKAKEKYVKNTWKLHALHNQYVLAVK 195

Human   192 AAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHREMAAAAARIQ 256
            ||||||:||....||.|..|:|.:|:||..|||.|:|||.||:||||:||.::|||:|:|...|.
Frog   196 AAQLHHEHHFLYSLPTLHESMQSIHQEMVQILKNIMQEYSEITSLVQEEVASLHREIASAVNSIS 260

Human   257 PEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESVQHTLTSVTDELAVAT 321
            |..||..||:...|..::||.||||.|||||.:.||. |||||:|||||||||||||.:|||..|
Frog   261 PFKEYDNFLQMNRSVSELPPIVTFDTSLLEETDDLEE-ELQLNDLTVESVQHTLTSVEEELASVT 324

Human   322 EMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQGLQVALCSQAKLQAQQELLQT 386
            ..:..:|::|.||:.::..||..|..||::.||.||..|::||....:.||::.|:..|:|.|:.
Frog   325 AAIEGKQDIVKQLRSDIATEERTTDCREKINLLAKRHALRDALLQYHMTLCNKNKIHGQREKLKR 389

Human   387 KLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEILKSHISGIFRPKFSLPPPLQLIPEV 451
            |:..:|.|:|||.|.||||..|.||  .|||.|: .|||.:|:||||||||||||||.|.|||:|
Frog   390 KMNTIGSGDPPPALQLQDDNQSISS--VERECGK-KTLENIKNHISGIFRPKFSLPPLLPLIPDV 451

Human   452 QKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQGKQEYVLSVLWDGLPRHFIIQSLDNLYRLE 516
            ||||.:|.||||||||:||..|||::||||:|||||||||||||||:|.|||||||::||.||||
Frog   452 QKPLSQQNWYHGAIPRSEVQGLLVNNGDFLIRESQGKQEYVLSVLWEGQPRHFIIQNVDNCYRLE 516

Human   517 GEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLR 581
            ||||.:|||||||.|.|:|.:||||||:|::||.||||||.||:::|||:||:||||||||||||
Frog   517 GEGFSTIPLLIDHFLKTKQAVTKKSGVILNKAVVKDKWVLEHEEVILGERIGKGNFGEVFSGRLR 581

Human   582 ADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLT 646
            ||||.|||||||:|||||||.|||.||||||||||||||:||||||||.||||||||||||||.|
Frog   582 ADNTPVAVKSCRDTLPPDLKDKFLMEARILKQYSHPNIVKLIGVCTQKHPIYIVMELVQGGDFQT 646

Human   647 FLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADG 711
            |||.||.:|:||.|::|..:|||||||||||.||||||||||||||||||||||||||||||.||
Frog   647 FLRNEGPKLKVKELIRMSENAAAGMEYLESKHCIHRDLAARNCLVTEKNVLKISDFGMSREEEDG 711

Human   712 VYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKG 776
            ||:::||::|:|||||||||||||||||||||||||:||||.||||:.||..:|||||||.:|:|
Frog   712 VYSSTGGMKQIPVKWTAPEALNYGRYSSESDVWSFGVLLWEAFSLGSVPYATMSNQQTREIIEQG 776

Human   777 GRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR 822
            .||..|:.|||.|:.||.:||.|:|.:||:|||::|||.|||||||
Frog   777 IRLLVPDNCPDEVYSLMLRCWEYDPKKRPNFSTVHQELVSIRKRHR 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FES	NP_001996.1	Important for interaction with membranes containing phosphoinositides	1..300		172/302 (57%)
		F-BAR_Fes	7..239	CDD:153369	136/235 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	394..421		16/26 (62%)
		SH2_Fps_family	453..537	CDD:198224	64/83 (77%)
		Pkinase_Tyr	561..814	CDD:285015	196/252 (78%)
		PTKc_Fes	564..815	CDD:270667	196/250 (78%)
fes	XP_002932286.2	F-BAR_Fes	7..243	CDD:153369	136/235 (58%)
		SH2_Fps_family	453..537	CDD:198224	64/83 (77%)
		PTKc_Fes	564..815	CDD:270667	196/250 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	419	1.000	Domainoid score	I5447
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37563
Inparanoid	1	1.050	1087	1.000	Inparanoid score	I2684
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG47024
OrthoDB	1	1.010	-	-		D255116at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		oto148926
Panther	1	1.100	-	-	LDO	PTHR24418
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3894
SonicParanoid	1	1.000	-	-		X1749
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	13.110