DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and fer

DIOPT Version :9

Sequence 1:	XP_011541568.1	Gene:	FER / 2241	HGNCID:	3655	Length:	837	Species:	Homo sapiens
Sequence 2:	XP_009300152.1	Gene:	fer / 565199	ZFINID:	ZDB-GENE-060526-234	Length:	827	Species:	Danio rerio

Alignment Length:	842	Identity:	637/842 - (75%)
Similarity:	742/842 - (88%)	Gaps:	22/842 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MGFGSDLKNSHEAVLKLQDWELRLLETVKKFMALRIKSDKEYASTLQNLCNQVDK-ESTVQMNYV 64
            ||||.||:||||.::|||||||:||||||:||.||:||||||||.|.|:..|||| :::.|::||
Zfish     1 MGFGRDLRNSHEGLMKLQDWELKLLETVKRFMTLRVKSDKEYASLLINISQQVDKHDNSSQIHYV 65

Human    65 SNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYIGVHQQIEAEMIKVT 129
            |:|||||..|:|||||||:|||.|||:|||||||||||||||||||||||..:|||||:||.|||
Zfish    66 SHVSKSWTHMVQQTEQLSKIMKCHAEELNSGPLHRLTMMIKDKQQVKKSYQSLHQQIESEMNKVT 130

Human   130 KTELEKLKCSYRQLIKEMNSAKEKYKEALAKGKETEKAKERYDKATMKLHMLHNQYVLALKGAQL 194
            |::||:|||:||||.|:...|:||||:|:.||||||||:|||||||||||.||||||||:|.|||
Zfish   131 KSDLERLKCTYRQLTKDAVLAREKYKDAVLKGKETEKARERYDKATMKLHNLHNQYVLAVKSAQL 195

Human   195 HQNQYYDITLPLLLDSLQKMQEEMIKALKGIFDEYSQITSLVTEEIVNVHKEIQMSVEQIDPSTE 259
            ||..|::..||||||||||||||||.|||||.:|||:||||:|:|||.|||||..|::||||.:|
Zfish   196 HQEHYHEFALPLLLDSLQKMQEEMISALKGILEEYSEITSLLTDEIVKVHKEIHTSIDQIDPLSE 260

Human   260 YNNFIDVHRTTAAKEQEIEFDTSLLEENENLQANEIMWNNLTAESLQVMLKTLAEELMQTQQMLL 324
            |:|||:|:::..|||..:|||.:||:|.||||||||:||||||:|||||||:..|||:.|||.|.
Zfish   261 YDNFIEVYKSPEAKEPNVEFDATLLDETENLQANEILWNNLTADSLQVMLKSTTEELLITQQNLH 325

Human   325 NKEEAVLELEKRIEESSETCEKKSDIVLLLSQKQALEELKQSVQQLRCTEAKFSAQKELLEQKVQ 389
            :||:.:|:|||::|||::..|||||:||.|||:|.||||:|:||.|||:|||..||:||||||:|
Zfish   326 SKEDLMLDLEKKMEESTKAYEKKSDVVLFLSQRQFLEELRQTVQLLRCSEAKLMAQRELLEQKMQ 390

Human   390 ENDGKEPPPVVNYEEDARSVTSM------ERKERLSKFESIRHSIAGIIRSPKSALGSSALSDMI 448
            ||:|||||||||||||||||.||      :.|:|:|||:::|||||||||||||.||||:..|:|
Zfish   391 ENEGKEPPPVVNYEEDARSVNSMVMHHLDKSKDRISKFDTLRHSIAGIIRSPKSVLGSSSFFDVI 455

Human   449 SISEKPLAEQDWYHGAIPRIEAQELLKKQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNM 513
            ..|||||.||:||||||||.|||||||:||||||||||||||||||||:|||||||||||:.||.
Zfish   456 PTSEKPLGEQEWYHGAIPRTEAQELLKQQGDFLVRESHGKPGEYVLSVFSDGQRRHFIIQFADNQ 520

Human   514 YRFEGTGFSNIPQLIDHHYTTKQVITKKSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEVY 578
            ||||||||..||||||||||||||||||||||||||:.|||||||:||||||||||||||||||:
Zfish   521 YRFEGTGFPTIPQLIDHHYTTKQVITKKSGVVLLNPVIKDKKWILNHEDVILGELLGKGNFGEVF 585

Human   579 KGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGG 643
            ||||:|||.||||||||||||:||||||.||:||||||||||||||||||||||:||:||||.||
Zfish   586 KGTLRDKTPVAVKTCKEDLPQDLKIKFLSEARILKQYDHPNIVKLIGVCTQRQPIYIVMELVPGG 650

Human   644 DFLTFLRRKKDELKLKQLVKFSLDAAAGMLYLESKNCIHRLCEGKGEMKETSNLGDLAARNCLVG 708
            |||:|||:||::||.||||||:||||.||.|||.||||||               ||||||||||
Zfish   651 DFLSFLRKKKEDLKTKQLVKFALDAAGGMAYLELKNCIHR---------------DLAARNCLVG 700

Human   709 ENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGV 773
            |||||||||||||||||.|:||||||||||||||||||||||||||||||||:||||||||||||
Zfish   701 ENNVLKISDFGMSRQEDDGIYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSYGILLWETFSLGV 765

Human   774 CPYPGMTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKELTIIKRK 835
            ||||||||||||||||:|||||.||.||:::.::|.:||:|||||||||:::||||..:|:|
Zfish   766 CPYPGMTNQQAREQVEKGYRMSCPQKCPDEVYRVMQRCWEYKPENRPKFADIQKELAAVKKK 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	XP_011541568.1	F-BAR_Fer	5..238	CDD:153370	172/233 (74%)
		SH2_Fps_family	453..538	CDD:198224	74/84 (88%)
		Pkinase_Tyr	563..829	CDD:285015	214/265 (81%)
		PKc_like	566..831	CDD:304357	213/264 (81%)
fer	XP_009300152.1	F-BAR_Fer	5..239	CDD:153370	172/233 (74%)
		SH2_Fps_family	460..545	CDD:198224	74/84 (88%)
		PKc_like	573..823	CDD:328722	213/264 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194339013
Domainoid	1	1.000	518	1.000	Domainoid score	I2515
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74300
Inparanoid	1	1.050	1298	1.000	Inparanoid score	I1356
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG47024
OrthoDB	1	1.010	-	-		D255116at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		otm27124
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	LDO	PTHR24418
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3894
SonicParanoid	1	1.000	-	-		X1749
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	17	17.440