Protein Alignment FER and Shark

DIOPT Version :10

• Sequence 1: XP_011541571.1
• Gene: FER / 2241
• HGNCID: 3655
• Length: 837
• Species: Homo sapiens
• Sequence 2: NP_524743.2
• Gene: Shark / 44353
• FlyBaseID: FBgn0015295
• Length: 939
• Species: Drosophila melanogaster
• Alignment Length: 953
• Identity: 209/953 - (21%)
• Similarity: 356/953 - (37%)
• Gaps: 324/953 - (33%)

Human   134 EKLKCSYRQ---LIKEMNSAKEKY-KEALAKGKETEKAKERY----------DKATMKLHMLHNQ 184
            |.||..|..   |::|.::|...: ...|.:|:.......|:          ||...|:  ||..
  Fly    22 ELLKQGYEDGTFLVRESSTAAGDFVLSLLCQGEVCHYQVRRHGGEDAFFSIDDKVQTKI--LHGL 84

Human   185 YVLALKGAQLHQNQYYD---------ITLPLLLD---------------------SLQKMQEEMI 219
            ..|.         .||.         :|:||:.|                     :..|:..|::
  Fly    85 DTLV---------DYYQQAANGLPTKLTVPLIRDLPPHNTRSHGVTNLLHRATSKNESKVVFELL 140

Human   220 KALKGIFDEYSQ-------ITSLVTEEIVNVHKEIQMSVEQIDPSTEYNNFIDVHRTTAAKEQEI 277
            |.....||..:|       :.:|.::|  ::.|.:..:..|::.|..: ....:|  .||:.:..
  Fly   141 KCGYRNFDAKNQDGQTALHLAALHSDE--DILKHLLNAKVQVNSSDSF-GCQPLH--YAARSKPA 200

Human   278 EFDTSLLEENENLQANEI-----------MWNNLTAESLQVMLKT----------------LAEE 315
            .|..:|:....|:|...|           ...||  |::|.:|..                ||:|
  Fly   201 SFIRTLISAQANVQGRNIDNGYVPLHEAAKHGNL--EAVQELLLAEAPPLPRTSSGEFPFDLAKE 263

Human   316 LMQT--QQMLLN-------------------KEEAVLELEKRIEE--------SSETC------- 344
            ..||  ::.|||                   :||||..|:|..:|        .:..|
  Fly   264 AGQTAVEEFLLNYKLPPANTTRDQWYHGTLTREEAVAILKKHAKELLAKQPEVDTSGCFLVRYSE 328

Human   345 -EKKSDIVLLLSQKQALE-------ELKQSVQQLRCTEAKF---------SAQKELLEQKVQEND 392
             ...|.:||.|...|.::       :|.|:..:::...:||         .:.:.|:...::.:.
  Fly   329 SPAASGLVLTLLCDQVVKNFRISQADLYQNGNKVQSGGSKFLYIDDGPYWPSVEHLIAHFMRFSY 393

Human   393 G----------KEPPPVV---------NYEEDARS-----------------------VTSMERK 415
            |          .:|.|.|         |.:..|.|                       :|..::|
  Fly   394 GLPVSLKYPVPPQPKPEVPSFATIPRSNMKPKAASPATPPTPVSPHSHHQHPHVPALTITKKKQK 458

Human   416 ERLSK-FESIRHSIAGIIRSPKSAL-----------------GSSALSDMISISEKPLAEQDWYH 462
            |..|. |.::|      :.|||.||                 ..|::|..::.:|:.|      .
  Fly   459 ENSSSMFNTLR------LTSPKKALFDMNSLRKNKSKGKRSDSESSVSGSLAGTEQEL------Q 511

Human   463 GAIPRIEAQELLKKQGDFLVRESHGKPGEYVLS---VYS--------------DGQRRHFIIQYV 510
            .|.|.:::   |....:|....:.|..|....:   ||:              ..|:....::|.
  Fly   512 AAAPMLKS---LSFSTEFSTFNADGVTGSGAAAAGEVYNVPRNNTPIEIDLPPIAQKTEAEVEYF 573

Human   511 ---------DNMYRFEGTGFS---NIPQLIDHHYTTKQVITKKSGVVLLNPIPKDK--------- 554
                     :...::.|.|:.   ::..|:|     :|:  |...|..||.:..:.
  Fly   574 TKSDVAIERERAGQWIGNGYQPTMDVLSLLD-----QQI--KAPAVARLNSLGPNASTESEMASY 631

Human   555 ----------------------KWILSHEDVILGELLGKGNFGEVYKGTL--------KDKTSVA 589
                                  ::.:..|.::|...:|.|.||.|:.|.|        :.:..||
  Fly   632 LHRKCSGTPSTPSATEVEAAKLRFFIEPEKLVLDREIGHGEFGSVHSGWLLRKSGAGEESRLEVA 696

Human   590 VKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKD 654
            :|...::  ...|.:||:||.::.:.:|..||:|||: .:.:.:.::.||...|..|.::.....
  Fly   697 IKMLSDE--HSNKQEFLREASVMMRLEHKCIVRLIGI-AKGEMLMMVQELAPLGSMLQYILDHGH 758

Human   655 ELKLK-QLVKFSLDAAAGMLYLESKNCIHRLCEGKGEMKETSNLGDLAARNCLVGENNVLKISDF 718
            |:... :|..::...|.||.||||::.:||               ||||||.|:...:..|||||
  Fly   759 EITANAELKVWASQIACGMHYLESQHFVHR---------------DLAARNILLTARHQAKISDF 808

Human   719 GMSRQEDGG----VYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGM 779
            ||||....|    .::..|  :.||:|.|||:.|.|.:|..|||||||:.:||.||||..||..:
  Fly   809 GMSRSLRPGSTEYQFTQGG--RWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEI 871

Human   780 TNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKF 822
            :|..|.:.|:.|.|:..|..||..|..:|..||..:|::||.|
  Fly   872 SNVDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTF 914

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FER	XP_011541571.1	F-BAR_Fer	5..238	CDD:153370	29/154 (19%)
		SMC_prok_B	107..>393	CDD:274008	72/389 (19%)
		SH2_Fps_family	453..538	CDD:198224	16/113 (14%)
		Protein Kinases, catalytic domain	566..831	CDD:473864	94/270 (35%)
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210	16/79 (20%)
		ANKYR	<94..317	CDD:440430	43/229 (19%)
		ANK repeat	124..151	CDD:293786	5/26 (19%)
		ANK repeat	153..184	CDD:293786	4/32 (13%)
		ANK repeat	186..217	CDD:293786	7/33 (21%)
		ANK repeat	220..245	CDD:293786	5/26 (19%)
		SH2_Cterm_shark_like	287..395	CDD:198211	18/107 (17%)
		PTKc_Syk_like	666..926	CDD:270650	94/269 (35%)