Protein Alignment FER and Ret

DIOPT Version :10

• Sequence 1: XP_011541571.1
• Gene: FER / 2241
• HGNCID: 3655
• Length: 837
• Species: Homo sapiens
• Sequence 2: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Alignment Length: 1030
• Identity: 218/1030 - (21%)
• Similarity: 372/1030 - (36%)
• Gaps: 356/1030 - (34%)

Human    40 KEYASTLQNLCNQVDKESTVQMNYVSNVSKSW---LLMIQQTEQLSRIMKTHAE---DLNSGPLH 98
            :||.|.|:::|.....:.|:..::.....|.:   :|:.....:.::.:..|..   .||:|..|
  Fly   133 EEYCSELEHICFWSSAQYTIAESHGPYRRKDFFEPVLIGALNSRAAKYLCPHVSLEYSLNAGSSH 197

Human    99 ------RL-TMMIKDKQQVKKSYIGVHQ---QIEAEM---IKVTKTELEKLKCSYRQLIKEMNSA 150
                  || |....|..::.    |::.   |::|.:   :|::..:..|........:.:.|..
  Fly   198 FVLKQNRLYTRQTLDHDELN----GLNAKAGQLQARITCTVKLSSRDQRKFSRILDIKLLDRNDN 258

Human   151 KEKYKEALAK------------GKETEKAKERYDKATMK-----LHMLHNQ-------------- 184
            ..|.:|:.:|            .:|..|.....||.|::     ::.:||.
  Fly   259 GPKLQESSSKFDFYLEQPYFQADEEAGKKVIYVDKDTLEANAHLVYAVHNDSHGLFRPDCHAYEA 323

Human   185 --------------------------YVLALKGAQL-----------HQNQYYDITLPLLLDSLQ 212
                                      |.::|:...|           ..|..|.|.|..|.:|.|
  Fly   324 DHTGRPHTIVSCQLRFSRNGVFRETPYCVSLEARDLTIVSRVDAMSATANVCYHINLSKLHESEQ 388

Human   213 KMQEEM-IKALK-GIFDEYSQITSLVTEEIVNVHKEIQMSVEQIDPSTEYNNFIDVHRTTAAKEQ 275
            ::.:.: ::|.: .||:         :||.........:|    .|:.:|:..:.|:|:.|:..:
  Fly   389 ELPQALPLRARQHRIFE---------SEEFNGDSAGRSLS----PPTVDYDKDVSVYRSAASNFR 440

Human   276 EIEFDTSLLEENENLQANEIMWN---------NLTAESLQVMLKT--LAEELMQT---------- 319
            .::.|:.|    :.::...|.::         .:|:.|..|.:|.  :.||..:|
  Fly   441 VVQPDSFL----DLMRLRSIRFDIVEDKLGAFGITSTSGIVFVKNPQVLEEAPETIYFLNVTWID 501

Human   320 QQMLLNKEEAVLEL----------EKRIEESSETCEKKSDIVLLLSQKQA--------------- 359
            ||.|.:.....:.|          |.:::..|:||.:      :..|.|.
  Fly   502 QQRLSHVRVINVHLVHGRPENTSCELKVKSRSQTCAQ------IKYQSQCVRYCGLATGGGSCQW 560

Human   360 -----------------------------LEELKQSVQQLRCTEA-KFSAQKELLEQK------- 387
                                         ||||........||.| :........|.|
  Fly   561 RGSNSAMFGTRYGSCVPESRYCPDHVCDPLEELNPMACPQDCTPAGRIVGPHSSNENKRGIYSAS 625

Human   388 ---VQENDGK-------EPPPVVNYEEDARSVTSMERKERLSKFESIRHSIAGIIRS--PKSALG 440
               :.|::||       |.|.:              :|.|..|.|:....:.|:.|.  |...|.
  Fly   626 GTCICEDNGKCSCAPLDEEPKM--------------KKPRKRKNETEAEPLLGVRRGTPPNQPLQ 676

Human   441 SSALSDMIS-----------------------------ISEKPLAEQDWYHGAIPRIEAQELL-- 474
            ...|..:::                             |:::.:.::        |:..|.:.
  Fly   677 DPMLLGVLNVAGFECDRSCMFFVITCPLLFVLLLLCLLIAQRKMLQR--------RLGKQSMTTS 733

Human   475 KKQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYRFEGTGFSNIPQLIDHHYTTKQVIT 539
            .||.   :.||.|  |::.|.....|             :|||
  Fly   734 SKQA---LPESGG--GDFALMPLQSG-------------FRFE---------------------- 758

Human   540 KKSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEVYKG------TLKDKTSVAVKTCKEDLP 598
              ||         |.||....|.:.|..:||:|.||:|.||      .|...|:||||..|:...
  Fly   759 --SG---------DAKWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSN 812

Human   599 QELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKK---------- 653
            ....:..|.|.::|::..|||::||:|.||..:...:|:|....|...::||..:
  Fly   813 SVEYMALLSEFQLLQEVSHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFA 877

Human   654 ---DELKLKQLVKFSLDAAAGMLYLESKNCIHRLCEGKGEMKETSNLGDLAARNCLVGENNVLKI 715
               :.:.:|.::.|:.....||.||.....:||               ||||||.|:.:..:.||
  Fly   878 DGVEPVNVKMVLTFAWQICKGMAYLSELKLVHR---------------DLAARNVLLADGKICKI 927

Human   716 SDFGMSRQ--EDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPG 778
            ||||::|.  || ..|......::|:||.|||:|....|:|:|||||||:|.||..:||..||||
  Fly   928 SDFGLTRDVYED-DAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPG 991

Human   779 MTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKF----SELQKEL 829
            :..|.....::.||||..|::|.|.:..|:..||..:|..||.|    ||.:|.|
  Fly   992 IAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLL 1046

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FER	XP_011541571.1	F-BAR_Fer	5..238	CDD:153370	46/286 (16%)
		SMC_prok_B	107..>393	CDD:274008	67/447 (15%)
		SH2_Fps_family	453..538	CDD:198224	13/86 (15%)
		Protein Kinases, catalytic domain	566..831	CDD:473864	100/289 (35%)
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	101/293 (34%)