Protein Alignment FER and Csk

DIOPT Version :10

• Sequence 1: XP_011541571.1
• Gene: FER / 2241
• HGNCID: 3655
• Length: 837
• Species: Homo sapiens
• Sequence 2: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Alignment Length: 900
• Identity: 234/900 - (26%)
• Similarity: 373/900 - (41%)
• Gaps: 202/900 - (22%)

Human    87 THAEDLNSGPL-----------HRLTMMIKDK---QQVKKSYIGVHQQIEAEMIKVTKTELEKLK 137
            |.|:..:|.|:           ||.....|.|   ||.|..::|..::..::..:.|...|..:.
  Fly   196 TSAKHESSPPIDARLLNFLRCAHRKFQASKAKTELQQTKDRFLGNSRERTSKNGQQTSRSLPPIA 260

Human   138 CSYRQLIKEMNSAK---EKYKEALAKGKETEKAKE----------------------RYDKATMK 177
            .|.....:|..:.|   ||.::...|.:|..|.||                      |...||..
  Fly   261 SSEEWFDEEAQARKTSHEKSQKPKPKPEENHKEKEAISRKASGEGDLITVEIKQGLLRKQTATTT 325

Human   178 LHMLHNQYVLALKGAQL----HQNQYY--DITL------------PLLLDSL------------Q 212
            .....|.:..|.:..|.    |...:.  .:|:            |..|.:.            .
  Fly   326 TGQAMNSHATATQNGQTTVVGHHRGFSQPSVTVAAAAATGSTAGDPWFLQTTGHQMPPTAPLRHN 390

Human   213 KMQEEMIKALKGIFDEYSQITSLVTEEIVNVHKEIQMSVEQ-------IDPSTEYNNFIDVHRTT 270
            |.......|:.|.....:...|.|  ..|.:|:: |:|..|       |.|...::...:||...
  Fly   391 KRPAPQPNAVLGAGSSGTAPGSAV--GAVLLHQQ-QLSQSQPHIVPPSIPPHHHHHRENNVHPIQ 452

Human   271 AAKEQEIEFDTSLLEENENLQANEIMWNNLTAESLQVMLKTLAEELMQTQQM----LLNKEEAVL 331
            |.....:...:..| .:.||.::....:..:....|...:|..::..|.||.    :|:......
  Fly   453 AGAAAALHLSSHAL-NSHNLISSASNHSPKSPSQTQQQQQTTNQQQQQQQQQASHSILSTFAPAP 516

Human   332 ELEKRIEESSETCEKKSDIVLLLSQKQALEELK----------------QSVQQL------RCTE 374
            .:.......|::....:..|..::|:|..:.|:                .:..|:      |...
  Fly   517 TVAAVQPAGSQSVAGTAAAVAAVAQQQQQQHLQLLANCPPGGAGLMSSSLNAAQMGMHGAERALP 581

Human   375 AKFSA-------QKELLEQKVQENDGKEPPPVVNY--EEDARSVTSMERKERLSKFESIRHSI-- 428
            .|..|       ...||....|.....:|..||..  ...|...||:             ||.
  Fly   582 PKSLALSGSQHGSNMLLHTAPQPPQASQPAAVVGVSGSGSAGMSTSL-------------HSFDI 633

Human   429 ------AGIIRSPKSALGSSALSDMISISEKPLAEQD-------------WYHGAIPRIEAQELL 474
                  :|:..|...:.||:...:..|:|...||.|.             |:||:|.|.||:.||
  Fly   634 NGVTAGSGVNASSAWSSGSTTAMNHASLSPTALAPQQGRSRCEVKLNAMPWFHGSITRDEAEHLL 698

Human   475 --KKQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYRFEGTG-FSNIPQLIDHHYTTKQ 536
              ::.|.||||||...||:|.|.|....:..|:.::|::|....:... |.|:.||:.|:.....
  Fly   699 QPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKYLENKLTIDDEEYFENLGQLVAHYEADAD 763

Human   537 VITKKSGVVLLNPIPK--------------DKKWILSHEDVILGELLGKGNFGEVYKGTLKDKTS 587
            .:..:    |:..:||              ||.|::...::.|.|.:|||.||:|..|.|::: .
  Fly   764 GLCTQ----LIKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLGILRNE-K 823

Human   588 VAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLR-R 651
            ||||..|::...:   |||.||.::...:|.|:||.||:....:.:|::.|.:|.|..:.:|| |
  Fly   824 VAVKMLKDEGAVQ---KFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSR 885

Human   652 KKDELKLKQLVKFSLDAAAGMLYLESKNCIHRLCEGKGEMKETSNLGDLAARNCLVGENNVLKIS 716
            .:..:..|..:.|:.|.|:||.|||:|..:||               ||||||.|:.|:.|.|:|
  Fly   886 GRQHITKKDQIIFAYDTASGMEYLEAKKVVHR---------------DLAARNVLISEDCVAKVS 935

Human   717 DFGMSRQE----DGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYP 777
            |||::|:|    |.|        ::||||||||||..||:|::||:|||||||||.:|.|..|||
  Fly   936 DFGLAREECYNLDVG--------KLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYP 992

Human   778 GMTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKELTII 832
            .:......:.||.||:|.||:.||.:|.::|.:.||..|..||.|:||:.:|.::
  Fly   993 RIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAELKVKLQLL 1047

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FER	XP_011541571.1	F-BAR_Fer	5..238	CDD:153370	39/219 (18%)
		SMC_prok_B	107..>393	CDD:274008	63/383 (16%)
		SH2_Fps_family	453..538	CDD:198224	32/100 (32%)
		Protein Kinases, catalytic domain	566..831	CDD:473864	111/269 (41%)
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	32/100 (32%)
		PTKc_Csk_like	793..1047	CDD:270635	113/280 (40%)