DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment FER and FER

DIOPT Version :9

Sequence 1:XP_011541568.1 Gene:FER / 2241 HGNCID:3655 Length:837 Species:Homo sapiens
Sequence 2:NP_524288.3 Gene:FER / 41118 FlyBaseID:FBgn0000723 Length:1325 Species:Drosophila melanogaster


Alignment Length:1333 Identity:339/1333 - (25%)
Similarity:518/1333 - (38%) Gaps:531/1333 - (39%)


- Green bases have known domain annotations that are detailed below.


Human     1 MGFGSDLKN--SHEAVLKLQDWELRLLETVKKFMALRIKSDKEYASTLQNLCNQ---VDKESTVQ 60
            |||.|.|::  :|||::..||.||||:||:|:.:.::.|.|||||.:|..:..|   :|:...:|
  Fly     1 MGFSSALQSRAAHEALIVRQDAELRLMETMKRSIQMKAKCDKEYAISLTAVAQQGLKIDRADEMQ 65

Human    61 MNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYIGVHQQIEAEM 125
               .|.:||||...:.:.:..::..|.:||.|.. ...:||.:.:||::.:|:|...|.:|.|.:
  Fly    66 ---GSLISKSWRSYMDELDHQAKQFKFNAEQLEV-VCDKLTHLSQDKRKARKAYQEEHAKIAARL 126

Human   126 IKVTKTELEKLKCSYRQLIKEMNSAKEKYKEALAK-----GKETEKAKERYDKATMKLHMLHNQY 185
            ..:| .|:.:.|..|::.::...:.:.:::|...|     |::.:..:::|.||..|||:.||:|
  Fly   127 NHLT-DEVVRKKSEYQKHLEGYKALRTRFEENYIKAPSRSGRKLDDVRDKYQKACRKLHLTHNEY 190

Human   186 VLALKGAQLHQNQYYDITLPLLLDSLQKMQEEMIKALKGIFDEYSQITSLVTEEIVNVHKEIQMS 250
            ||::..|...:..:.::.||.||:..|.:||..|...:.|..|.:|...|..::...:.|.|...
  Fly   191 VLSITEAIEVEKDFRNVLLPGLLEHQQSVQESFILLWRNILQEAAQYGDLTADKYKEIQKRIDTV 255

Human   251 VEQIDPSTEYNNFIDVHRTTAAKEQEIEFDTSLLEE-NENLQANEIMWNNLTAESLQVMLKTLAE 314
            :..|:|:.||..|.:.::|:.......:||.:|::: ...||::.:..:|||.:.|:..|:.|..
  Fly   256 IGSINPTEEYGEFTEKYKTSPTTPLLFQFDETLIQDIPGKLQSSTLTVDNLTVDWLRNRLQELEG 320

Human   315 ELMQTQQMLLNKEEAV---------------LELEKRIEESSET-CEKKSDIVLLL---SQKQAL 360
            .:...|:..:...|.|               ......|:.:.:: |.:..|:..|.   .|||.|
  Fly   321 AVRDCQEKQMKMIEHVNGGSPVANGSIISNGSNTSNGIQSNKDSLCRQSKDLNALRCQEKQKQKL 385

Human   361 -EELKQSVQQLRCTEAKFSAQKEL-LEQKVQEN-------------------------------- 391
             :.:|.::.::.|.|.......:| |||...||                                
  Fly   386 VDMIKCALNEVGCEELPSGCDDDLTLEQNFIENGYNNEQQRSNSTSSPGLGIMNELMRRGGVLTL 450

Human   392 ---------------------------------------------DGKEPPPV------------ 399
                                                         ||..|.|.            
  Fly   451 LRGRGRHFKRKSTPQPATPMTRSRQGRFNKLQPRSQSLGSLSVIRDGNGPSPARYEPITNHRLRQ 515

Human   400 ---VNY--EEDARSVTS------------------------------------------------ 411
               |:|  ||.|.|.|:                                                
  Fly   516 AASVHYLGEEIATSSTNPPDLTRLRRTQCSMLCLGEDEEPVVLASPAPLTQLTAAVLTNTNNNHI 580

Human   412 -----MERKERLS------------KFESIR---------------------------------- 425
                 :::|:..|            |.|.||                                  
  Fly   581 YADLELDKKKDTSPSPECKGEQIQPKKEQIRIEINQTAPQNSIDAHLDRIDELNRVLDDRLKRTL 645

Human   426 ----------------------------------------------------------HSIAGII 432
                                                                      .||:.|.
  Fly   646 QPSDDVNAIESAEENHIQTRKLAKDPDSQTKRSSSSSSECRSSKDTSHSKKRSLSFSQKSISNIF 710

Human   433 -------RSPKSALG-------------------------------------------------- 440
                   :||...:|                                                  
  Fly   711 SNLKEFSKSPLVRMGKNHILNEEQDAKRTQPSQHHHSSGSDCPTNSSSSSSNNNNNNKNTSSNSN 775

Human   441 ----------------------------------------------------------------- 440
                                                                             
  Fly   776 HSASQSTIITSTITTTITTTTTTTPSKENSRLKFKVPKIQKKSKAIRNTFRSKLLNFQLKRSKPC 840

Human   441 ----------------------------------------------------------------- 440
                                                                             
  Fly   841 KQCTKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQFCNCPPAGQKPVKPSVQISGHKDHPFESSS 905

Human   441 ------------------SSALSDMISISE-----------------KPLAEQDWYHGAIPRIEA 470
                              .||..|::|:.:                 :||.|::|:||.:||.|.
  Fly   906 GELDENSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSLAASISLSTNRPLYEEEWFHGVLPREEV 970

Human   471 QELLKKQGDFLVRES-HGKPGEYVLSVYSDGQRRHFIIQYV-DNMYRFEGTGFSNIPQLIDHHYT 533
            ..||...|||||||: ..:..:.||||..:| .:|||:|.. :..:||||..|::|.:||.|.|.
  Fly   971 VRLLNNDGDFLVRETIRNEESQIVLSVCWNG-HKHFIVQTTGEGNFRFEGPPFASIQELIMHQYH 1034

Human   534 TKQVITKKSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEVYKGTLKD-KTSVAVKTCKEDL 597
            ::..:|.|||.:|..|:.:: :|.||::||:|.|.:|:||||:|||..||. |..||||||:..|
  Fly  1035 SELPVTVKSGAILRRPVCRE-RWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTL 1098

Human   598 PQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQLV 662
            |.|.|.|||||.:|||||||||||||||:|.|:||:.|:||||.||..||:||:..:.|..:|.:
  Fly  1099 PDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQM 1163

Human   663 KFSLDAAAGMLYLESKNCIHRLCEGKGEMKETSNLGDLAARNCLVGENNVLKISDFGMSRQEDGG 727
            ....||||||.||||||||||               |||||||||...:.:|||||||||:|:..
  Fly  1164 GMCRDAAAGMRYLESKNCIHR---------------DLAARNCLVDLEHSVKISDFGMSREEEEY 1213

Human   728 VYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGY 792
            :. |.|:||||:|||||||||:|:|:|..||||:|||:||.||.|..||.||||.:|||:::.||
  Fly  1214 IV-SDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGY 1277

Human   793 RMSAPQHCPEDISKIMMKCWDYKPENRPKFSEL 825
            ||..|:..||::.::|::||....|:||.|.|:
  Fly  1278 RMPTPKSTPEEMYRLMLQCWAADAESRPHFDEI 1310

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FERXP_011541568.1 F-BAR_Fer 5..238 CDD:153370 73/242 (30%)
SH2_Fps_family 453..538 CDD:198224 37/86 (43%)
Pkinase_Tyr 563..829 CDD:285015 150/264 (57%)
PKc_like 566..831 CDD:304357 148/261 (57%)
FERNP_524288.3 F-BAR_Fes_Fer 7..243 CDD:153341 72/245 (29%)
SH2_Fps_family 953..1039 CDD:198224
TyrKc 1063..1311 CDD:197581
PTKc_Fes_like 1067..1315 CDD:270637


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 310 1.000 Domainoid score I1327
eggNOG 1 0.900 - - E2759_KOG0194
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H74300
Inparanoid 1 1.050 552 1.000 Inparanoid score I1129
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D255116at33208
OrthoFinder 1 1.000 - - FOG0000006
OrthoInspector 1 1.000 - - otm42064
orthoMCL 1 0.900 - - OOG6_100013
Panther 1 1.100 - - O PTHR24418
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3894
SonicParanoid 1 1.000 - - X1749
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.860

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