Protein Alignment FER and Tak1

DIOPT Version :10

• Sequence 1: XP_011541571.1
• Gene: FER / 2241
• HGNCID: 3655
• Length: 837
• Species: Homo sapiens
• Sequence 2: NP_524080.1
• Gene: Tak1 / 39659
• FlyBaseID: FBgn0026323
• Length: 678
• Species: Drosophila melanogaster
• Alignment Length: 284
• Identity: 85/284 - (29%)
• Similarity: 128/284 - (45%)
• Gaps: 41/284 - (14%)

Human   562 DVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGV 626
            ::.|.|.:|.|::|.|.|...:||. ||||.......|:   ...:|.|.|.:..||||:.|.|:
  Fly    18 EITLREKVGHGSYGVVCKAVWRDKL-VAVKEFFASAEQK---DIEKEVKQLSRVKHPNIIALHGI 78

Human   627 CTQRQPVYIIMELVSGGDFLTFLRRK-KDELKLKQLVKFSLDAAAGMLYLES---KNCIHRLCEG 687
            .:.:|..|:|||...||....||..| |....|...:.::...|.|:.||.:   |..|||
  Fly    79 SSYQQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLHAMTPKPLIHR---- 139

Human   688 KGEMKETSNLGDLAARNCLV---GENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNY 749
                       |:...|.|:   |.|  |||.|||....:...:.::.|    ...|.|||....
  Fly   140 -----------DVKPLNLLLTNKGRN--LKICDFGTVADKSTMMTNNRG----SAAWMAPEVFEG 187

Human   750 GRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQARE-QVERGYRMSAPQHCPEDISKIMMKCWD 813
            .:|:.:.|::|:.|:|||..|... |:.|:.|....: ::.:|.|......||:.|..:|..||.
  Fly   188 SKYTEKCDIFSWAIVLWEVLSRKQ-PFKGIDNAYTIQWKIYKGERPPLLTTCPKRIEDLMTACWK 251

Human   814 YKPENRPKFS-------ELQKELT 830
            ..||:||...       |:.|:.|
  Fly   252 TVPEDRPSMQYIVGVMHEIVKDYT 275

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FER	XP_011541571.1	F-BAR_Fer	5..238	CDD:153370
		SMC_prok_B	107..>393	CDD:274008
		SH2_Fps_family	453..538	CDD:198224
		Protein Kinases, catalytic domain	566..831	CDD:473864	84/280 (30%)
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	82/275 (30%)