Protein Alignment FER and Src42A

DIOPT Version :10

• Sequence 1: XP_011541571.1
• Gene: FER / 2241
• HGNCID: 3655
• Length: 837
• Species: Homo sapiens
• Sequence 2: NP_001400996.1
• Gene: Src42A / 35524
• FlyBaseID: FBgn0264959
• Length: 1606
• Species: Drosophila melanogaster
• Alignment Length: 1014
• Identity: 251/1014 - (24%)
• Similarity: 427/1014 - (42%)
• Gaps: 276/1014 - (27%)

Human    12 EAVLKLQDWELRLLETVKKFMAL-RIKSDKEYAS--TLQNLCNQVDK----------ESTVQMNY 63
            ||:.|..|:..::|:  .:|.|. |.|:.|...|  ..:.|.|:::.          .:.|....
  Fly   656 EAMRKNSDFLSQILD--HQFAAKERAKAHKRRTSYEEFKRLVNEIEPLECPNTQPTVSAAVTPTT 718

Human    64 VSNVSKSWLLMIQQTEQ-------------LSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYI 115
            .:..:.:.|:..|.:.|             .::..||..|:.:..|       ||..|:.:.:..
  Fly   719 ATAAAAASLIKRQNSRQRKSFASYFLPHRHSTKEQKTEKENCSRDP-------IKPSQEQQLAVC 776

Human   116 GVHQQIEAEMIKVTKTELEKLKCSYRQ----------------LIKEMNSAKEKYKEALAKG--- 161
            |        .:.:.::....:..||.:                :|:..|...:||.:.:..|
  Fly   777 G--------KLPLHRSNTSDISSSYYRRNFKIYDKLVYGTIYDIIQRKNDIYQKYDKYMTYGTIY 833

Human   162 ----KETEKAKERYDKATMKLHMLHNQYVLALKGAQ----------------------------- 193
                ::|.::.:.:.:.::.         ..|:|.:
  Fly   834 EILHRKTSQSSDPWQRKSLS---------SILEGGRSSGDIIYDIGQRRERDKRTLGSSSSATVS 889

Human   194 -LHQNQY---YDITLPLLLDS--LQKMQEEMIKALKGIFDEYSQITSLVTEEIV---------NV 243
             ::.::|   |||...:.:|:  ::...::..|..|   ...::.|..|..::|         ..
  Fly   890 TINPHKYGTIYDILQGVKIDAGHVKNKPDQKSKPTK---PPLAKPTRFVVSQVVEPVQIPPTDQS 951

Human   244 HKEIQMSVEQIDPST-------EYNNFIDVHRTTAAKEQEIEFDTSLLEEN--ENLQA-NEIMWN 298
            .|.:|   ||..|.:       ..:|.:...|.:...:||    |:..||.  :..|| ..|...
  Fly   952 GKSVQ---EQGAPKSNKPNKMRRLSNILSYSRNSGEDQQE----TTGKEETKPKRTQAKRRIGVT 1009

Human   299 NLTAESLQVMLKTLAEEL---MQTQQMLLNKEEAVLELEKRIEESSETCEKKSDIVLLLSQKQAL 360
            ||       :|...:|||   :..||..|:||.: .|.|::.....:.|.:.:     |::..:|
  Fly  1010 NL-------LLPLDSEELYTRIIAQQRGLDKEHS-QEPEEKCASEEQMCTRNA-----LTKSSSL 1061

Human   361 EEL-----------------KQSVQQLRCTEAKFS---AQKELLE---QKVQENDGKEP------ 396
            :.:                 ::|::|.||.:....   |:|..|:   |.|.....::|
  Fly  1062 DAISLSVAISPASSPSPPRPRRSLKQHRCLQQHQQTPLAKKHSLDNCLQVVSSTTSRQPLRRWSN 1126

Human   397 -PPV---VNYEEDARSVTSMERKERL--SKFESIRHSIAG---IIRSP-------KSALGSSALS 445
             .|:   .:...:...:|::|:...|  :...|..|:.|.   |.:||       |::|.::...
  Fly  1127 QTPLKCTCHPATEELPLTAIEKSRSLPAACSASCSHTCAHLSVIDQSPATTKCFGKTSLTTAKKG 1191

Human   446 DMISISE----KPLAEQDWYHGAIPRIEAQELL----KKQGDFLVRESHGKPGEYVLSVYSDGQR 502
            ....:||    :.|.|:.||...|.||||::.|    .:.|.||:|:|..:..:|.|||......
  Fly  1192 KSRRLSEFTRGEFLNEKSWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSVRDGDTV 1256

Human   503 RHFIIQYVDNMYRFEG-------TGFSNIPQLIDHHYTTKQVITKKSGVVLLN------------ 548
            :|:.|:.:|     ||       |.|..:.:|::|:       :|.|..:.:|
  Fly  1257 KHYRIRQLD-----EGGFFIARRTTFRTLQELVEHY-------SKDSDGLCVNLCKPCVQTNSFS 1309

Human   549 -------PIPKD------KKWILSHEDVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDL--P 598
                   |:.:.      .:|.:....:.....||.|.||:|::|...:.|.||:||.|...  |
  Fly  1310 GVFEIEKPVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDP 1374

Human   599 QELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRR---KKDELKLKQ 660
            ::    ||.||:|:|:..|..:::|..|||..:|:|||.||:..|..|.:|:.   |...||::.
  Fly  1375 KD----FLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQT 1435

Human   661 LVKFSLDAAAGMLYLESKNCIHRLCEGKGEMKETSNLGDLAARNCLVGENNVLKISDFGMSRQED 725
            |:..:...||||.||||:|.|||               ||||||.|||:.|::||:|||::|...
  Fly  1436 LIDMAAQIAAGMAYLESQNYIHR---------------DLAARNVLVGDGNIVKIADFGLARLIK 1485

Human   726 GGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVER 790
            ...|.:....:.|||||||||.||.::|.:||||||||||.|..:.|..|||||||.:...|||.
  Fly  1486 EDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEH 1550

Human   791 GYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKEL 829
            ||||..|.:|...:.:||::||...|..||.|..||.:|
  Fly  1551 GYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETLQWKL 1589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FER	XP_011541571.1	F-BAR_Fer	5..238	CDD:153370	44/309 (14%)
		SMC_prok_B	107..>393	CDD:274008	62/388 (16%)
		SH2_Fps_family	453..538	CDD:198224	28/95 (29%)
		Protein Kinases, catalytic domain	566..831	CDD:473864	118/269 (44%)
Src42A	NP_001400996.1	SH2_Src_Src42	1210..1301	CDD:198233	29/102 (28%)
		PTKc_Frk_like	1328..1596	CDD:270653	119/281 (42%)