DRSC/TRiP Functional Genomics Resources

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Protein Alignment FER and Btk

DIOPT Version :10

Sequence 1:XP_011541571.1 Gene:FER / 2241 HGNCID:3655 Length:837 Species:Homo sapiens
Sequence 2:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster


Alignment Length:419 Identity:148/419 - (35%)
Similarity:221/419 - (52%) Gaps:48/419 - (11%)


- Green bases have known domain annotations that are detailed below.


Human   435 PKSALGSSALSDMISISEKPLAEQDWYHGAIPRIEAQELLK---KQGDFLVRESHGKPGEYVLSV 496
            ||:.||              |...:||.|.:.|..|:.|||   |:|.|:||:|..| |.|.||:
  Fly   399 PKALLG--------------LERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSSTK-GLYTLSL 448

Human   497 YSDGQRRHFIIQYVD-----NMYRFEGTGFSNIPQLIDHH-YTTKQVITKKSGVVLLNPIP---- 551
            ::...:.|....::.     ..|..|......||.||::| :.:..:..:........|:|    
  Fly   449 HTKVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAG 513

Human   552 -KDKKWILSHEDVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQY 615
             ...||.:...:::|.|.||.|.||.|.:|..:.....|||..||....|  ..|::|||::.:.
  Fly   514 LSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSE--DDFIEEAKVMTKL 576

Human   616 DHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDEL--KLKQLVKFSLDAAAGMLYLESK 678
            .|||:|:|.|||::.:|:||:.|.:..|..|.:|||.:..|  .:..|:...:..:.||.|||..
  Fly   577 QHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERH 641

Human   679 NCIHRLCEGKGEMKETSNLGDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTA 743
            |.|||               ||||||||||..||:|::|||::|......|:|||..:.||||..
  Fly   642 NYIHR---------------DLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAP 691

Human   744 PEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHCPEDISKIM 808
            ||.|||.|:||:||||::|:|:||.|:.|..||..:.|.:..|:|:||..:..|:.|.::|..:|
  Fly   692 PEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVM 756

Human   809 MKCWDYKPENRPKFSELQKELTIIKRKLT 837
            ..||.:.||.||.|..|..:|.::.:.||
  Fly   757 KLCWSHGPEERPAFRVLMDQLALVAQTLT 785

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FERXP_011541571.1 F-BAR_Fer 5..238 CDD:153370
SMC_prok_B 107..>393 CDD:274008
SH2_Fps_family 453..538 CDD:198224 28/93 (30%)
Protein Kinases, catalytic domain 566..831 CDD:473864 109/266 (41%)
BtkNP_476745.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702 148/419 (35%)
SH2_Tec_family 403..505 CDD:198188 30/116 (26%)
PTKc_Tec_like 521..778 CDD:173637 109/273 (40%)
Blue background indicates that the domain is not in the aligned region.

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