Protein Alignment FER and CG3277

DIOPT Version :10

• Sequence 1: XP_011541571.1
• Gene: FER / 2241
• HGNCID: 3655
• Length: 837
• Species: Homo sapiens
• Sequence 2: NP_608762.3
• Gene: CG3277 / 33543
• FlyBaseID: FBgn0031518
• Length: 789
• Species: Drosophila melanogaster
• Alignment Length: 782
• Identity: 174/782 - (22%)
• Similarity: 306/782 - (39%)
• Gaps: 211/782 - (26%)

Human   193 QLHQNQYY-DITLPLLLDSLQKMQEEMIKALKGIFDEYSQITSLVTEEIVNVHKEIQMSV---EQ 253
            |:..::|. .::.|:.::.|.:|:...        :...:||.|.|...:.:.|..::.|   :.
  Fly    50 QMESHRYVTGLSEPIAMEPLTRMRLNP--------NPDGEITELTTNVTLYMEKIPRLQVRWQDN 106

Human   254 IDPSTEYNNFIDVHRTT----------AAKEQEIEFDTSL--LEENENLQANEIMWNNLTAESLQ 306
            :...|.||..:.....:          ..||:....:|..  |..|.||....:..|.:.....|
  Fly   107 LPQGTSYNVLVSAVNNSRCPDAPCSEYGIKEKNASAETHSVNLPVNPNLNVESVDCNYMFGCQYQ 171

Human   307 VMLKTLAEELMQTQQMLLNKEEAVLELEKRIE-----ESSETCE------KKSDIVLLLSQKQAL 360
            |:::|               ..|::....|:.     |...:|:      |...:..:||.:...
  Fly   172 VIVET---------------SNAMVRRSARVYIPQCLEGKCSCQLAPTPPKVLAVAKMLSNETIS 221

Human   361 EELKQSVQQLRCTEAKFSAQKELLEQKVQENDGKEPPPVVNYEEDARSVTSMERKERLSK--FES 423
            ..|.....:|...|......:.|...|:|....:|..|.:.:....:.:  |.|..:||:  |.:
  Fly   222 INLSILASELLRKEQDSHLHETLRTYKMQLKINEETNPSLPWGGVLKHL--MTRVYKLSELNFRA 284

Human   424 IRHSIAGIIRSPKSALGSSALSDMISIS-EKPLAEQDWYHGAIPR------IEAQELLKKQGDFL 481
            ......|::   |..||:. |.:..|:| :..:.:.....|  ||      :.|..:|..:|| .
  Fly   285 TPKGFEGVM---KLGLGTQ-LKEKASLSLQAVIIDPTGCEG--PRSVTKVPVPANPVLLTEGD-S 342

Human   482 VRESHGKPGEYVLSVYSDG-------------------QRRHFIIQYVDNMYRFEGTGFSNIPQL 527
            |..|.......::::...|                   |.:.:|..:..:....|    .|: ..
  Fly   343 VSNSIIVMSAMLIAIILAGLIMLLLRRRRARTTAKLRKQEQIYIQTFATSAIEME----DNV-NY 402

Human   528 IDHHYTTKQVITKKSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEVYKGT------LKDKT 586
            :|.:....||:    |:..:..:|        |..:.:|.:||:|.||:|::.|      ::..|
  Fly   403 VDKYVEKSQVL----GLADIFEVP--------HSAIQIGRMLGEGAFGQVHEATAINLRRMRGTT 455

Human   587 SVAVKTCKEDLPQELKIKFLQEAKILKQY-DHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLR 650
            .||||..|.:...:...::|.|.::||.. .|.|:|..:|.||.:.|..:|||.|:.|:.|::||
  Fly   456 IVAVKQLKPNPKADEVAEYLAEIEMLKGVGTHHNVVSFLGCCTIKPPYLMIMEYVNKGNLLSYLR 520

Human   651 R-KKDELKL-------------------------------------------------------- 658
            . :|:..||
  Fly   521 TVRKEASKLRNRNANYTSCRPIMTRTNSTSSPKSQSVNYIELKASSQTIEMPQEDSTAHMNGIRQ 585

Human   659 -------------------------KQLVKFSLDAAAGMLYLESKNCIHRLCEGKGEMKETSNLG 698
                                     |:|..|:|..|.||.:||.:...||
  Fly   586 PHPSFAETTYTIVEDEDAFEYILDNKELHNFALQIANGMRFLEEQEITHR--------------- 635

Human   699 DLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGI 763
            ||||||.|:..|..|||||||:||.   |:|:::..:::|::|.:.||:....|||:||:|::|:
  Fly   636 DLAARNVLIDSNKTLKISDFGLSRH---GIYTNTRTRKLPLRWLSIEAIRENVYSSKSDIWAYGV 697

Human   764 LLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKE 828
            :|||..:||..|||.::|.:....:..|.|:..|:.|...:..||::||..:||.||.|..|.|.
  Fly   698 VLWEIGTLGASPYPTISNDELIPFLMAGNRLERPEICTPQVYTIMLQCWLEEPEERPTFDALYKV 762

Human   829 LT 830
            |:
  Fly   763 LS 764

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FER	XP_011541571.1	F-BAR_Fer	5..238	CDD:153370	8/45 (18%)
		SMC_prok_B	107..>393	CDD:274008	38/226 (17%)
		SH2_Fps_family	453..538	CDD:198224	16/109 (15%)
		Protein Kinases, catalytic domain	566..831	CDD:473864	102/354 (29%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	100/350 (29%)