Protein Alignment FER and hop

DIOPT Version :10

• Sequence 1: XP_011541571.1
• Gene: FER / 2241
• HGNCID: 3655
• Length: 837
• Species: Homo sapiens
• Sequence 2: NP_511119.2
• Gene: hop / 32080
• FlyBaseID: FBgn0004864
• Length: 1177
• Species: Drosophila melanogaster
• Alignment Length: 929
• Identity: 199/929 - (21%)
• Similarity: 370/929 - (39%)
• Gaps: 246/929 - (26%)

Human    14 VLKLQDWELRL-LETVKKFMALRIKSDKEYASTLQNLCNQVDKESTVQMNYVSNVSKSW---LLM 74
            :.|:.|..:|| :..:.|...::.:::||..|.:..|            .....:|..|   |..
  Fly   367 ISKINDTSVRLEIVGLPKGYEMQFQTEKEMKSFISYL------------GIYIRLSSKWMQDLCH 419

Human    75 IQQTEQLSRIMKTHAEDLNSGPLHRLTMMIK-----DK----------QQVKKSYIGVHQQIEAE 124
            ..:|..|..:...|..    ||:.....::|     ||          ::....||.::.:|.|:
  Fly   420 SYRTPSLEELSSLHCH----GPIGGAYSLMKLHENGDKCGSYIVRECDREYNIYYIDINTKIMAK 480

Human   125 MIKVTKTELEKLKCSYRQLIKEMNSAKEKYKEA------------LAKGKETEKAK---ERYDKA 174
                 ||:.|:.|....:::::.:..|..|...            :.:....::.:   .:|||.
  Fly   481 -----KTDQERCKTETFRIVRKDSQWKLSYNNGEHVLNSLHEVAHIIQADSPDRYRIPASKYDKP 540

Human   175 TMKLHMLHNQYV-----LALKGAQLHQN-----------QYYDITLPLLLDSLQKMQEEMIKALK 223
            .:.|.:|.....     |.|..|:|.:.           |:|.       ||:....:.|:..::
  Fly   541 PLLLLLLPKNLKAKKTDLQLSEAELQRRNPQIFNPRTDLQWYP-------DSISLSDDGMMFTMR 598

Human   224 GIFDEYSQITSLVTEEIVNVHKEIQMSVEQIDPSTEYNNFIDVHRTTAAKEQEIEFDTSLLEENE 288
            |.:.:.|.:            |::.::::.:.....:..|..:.:|           .||::
  Fly   599 GDWIQQSPV------------KDVSVTMKMLKSDGNFMEFFRLAQT-----------WSLIQ--- 637

Human   289 NLQANEIMWNNLTAESLQVMLKTLAEELMQTQQMLLNKEEAVLELEKRIEESSETCEKKSDIVL- 352
                        :.:.|::...|||:......:.            .|....::......::.|
  Fly   638 ------------SPQFLKLYGLTLADPYTMVMEY------------SRYGPLNKFLHSMPNVTLH 678

Human   353 --------LLSQKQALEELKQSVQQLRCTE---AKFSAQKELLEQKV---------QENDGKEPP 397
                    |:.....||:.|.....:||:.   .|:.....:|:.|:         :|:|....|
  Fly   679 CLLDLMHGLVRGMHYLEDNKIIHNYIRCSNLYVTKYDPNSYVLDAKISDPGYPRPYRESDSPWIP 743

Human   398 PVVNYEEDARSVTSMERKERLSKFESIRHSIAGIIRSPKSALGSSALSDMISISEKPLAEQDWYH 462
              |.|..:.::.    :.::.::..:...:|..|.        |....|:.::.::.|..|....
  Fly   744 --VKYYRNLQAA----KTDQFAQLWAFATTIYEIF--------SRCKEDLSTLRQEQLLRQKNLD 794

Human   463 GAIPRIEAQELLKKQGDFLVRESHGKPG---EYVLSVYSDGQRRHF----IIQYVDNMYRFEGTG 520
            |.|.::..|::.              |.   |.::..:||.:.:.|    |...::.:.......
  Fly   795 GNILKMLDQDIC--------------PAPIFETIMDGWSDDETKRFSHHDIFSRLNTIKAEILPN 845

Human   521 FSNIPQLIDHHYTTKQVITK---------KSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGE 576
            :...|::..:....:.||.:         :|.::::.|:..:.:.|.:.|::|     |:|::|.
  Fly   846 YMPPPEIATNGTGDETVIDRSDIPFLPFPRSNMLMVIPLTSECRVIYNMENMI-----GRGHYGT 905

Human   577 VYKGTL----KD--KTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKL-----IGVCTQR 630
            ||||.|    ||  :..||:|...   ..::...|.:|..|::...||||||.     ...|
  Fly   906 VYKGHLEFNDKDQPREQVAIKMLN---TMQVSTDFHREIGIMRTLSHPNIVKFKYWAEKSHC--- 964

Human   631 QPVYIIMELVSGGDFLTFLRRKKDELKLKQLVKFSLDAAAGMLYLESKNCIHRLCEGKGEMKETS 695
                ||||.:..|.|..:||.....|...:||.|:||.|.||.||.....|||
  Fly   965 ----IIMEYLQSGSFDIYLRFTAPNLNNPRLVSFALDIANGMKYLSDMGLIHR------------ 1013

Human   696 NLGDLAARNCLV---GENNVLKISDFGMSR--QEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSE 755
               ||||||.||   |:.:.:||||||:::  ..||..|:.| .:.|||:|.:|||::..|:||.
  Fly  1014 ---DLAARNILVDHNGDGDCVKISDFGLAQFANSDGYYYAKS-KRDIPIRWYSPEAISTCRFSSY 1074

Human   756 SDVWSFGILLWETFSLGVCP--YPGMTNQQ-AREQVERGYRMSAPQHCPEDISKIMMKCWDYKPE 817
            |||||:|:.|:|.||.|..|  .|..|:|: ...:::.|.|::.|..||:.|..:|..||...|.
  Fly  1075 SDVWSYGVTLFEMFSRGEEPNLVPIQTSQEDFLNRLQSGERLNRPASCPDFIYDLMQLCWHATPR 1139

Human   818 NRPKFSELQKELTIIKRKL 836
            :||.|:.:   :.||.|::
  Fly  1140 SRPSFATI---VDIITREV 1155

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FER	XP_011541571.1	F-BAR_Fer	5..238	CDD:153370	46/273 (17%)
		SMC_prok_B	107..>393	CDD:274008	48/347 (14%)
		SH2_Fps_family	453..538	CDD:198224	12/91 (13%)
		Protein Kinases, catalytic domain	566..831	CDD:473864	102/283 (36%)
hop	NP_511119.2	B41	39..259	CDD:214604
		SH2_Jak_family	420..516	CDD:198177	18/104 (17%)
		PTK_Jak_rpt1	584..836	CDD:270633	45/329 (14%)
		PTKc_Jak_rpt2	886..1155	CDD:270634	108/302 (36%)