DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Fer

DIOPT Version :9

Sequence 1:	XP_011541568.1	Gene:	FER / 2241	HGNCID:	3655	Length:	837	Species:	Homo sapiens
Sequence 2:	NP_001382687.1	Gene:	Fer / 301737	RGDID:	1306273	Length:	823	Species:	Rattus norvegicus

Alignment Length:	838	Identity:	767/838 - (91%)
Similarity:	797/838 - (95%)	Gaps:	16/838 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MGFGSDLKNSHEAVLKLQDWELRLLETVKKFMALRIKSDKEYASTLQNLCNQVDKESTVQMNYVS 65
            ||||||||||.||||||||||||||||||||||||||||||||.|||||||||||:||||:||||
  Rat     1 MGFGSDLKNSQEAVLKLQDWELRLLETVKKFMALRIKSDKEYAYTLQNLCNQVDKDSTVQVNYVS 65

Human    66 NVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYIGVHQQIEAEMIKVTK 130
            |||||||||||||||||||||||||||||||||||||||||||||||||:|:|||||||||||||
  Rat    66 NVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYVGIHQQIEAEMIKVTK 130

Human   131 TELEKLKCSYRQLIKEMNSAKEKYKEALAKGKETEKAKERYDKATMKLHMLHNQYVLALKGAQLH 195
            |||||||.||||||||||||||||||||||||||||||||.||||||||||||||||||||||||
  Rat   131 TELEKLKSSYRQLIKEMNSAKEKYKEALAKGKETEKAKERCDKATMKLHMLHNQYVLALKGAQLH 195

Human   196 QNQYYDITLPLLLDSLQKMQEEMIKALKGIFDEYSQITSLVTEEIVNVHKEIQMSVEQIDPSTEY 260
            |:||||.||||||||:|||||||||||||||||||:||||||||||||||||||||:||||||||
  Rat   196 QSQYYDTTLPLLLDSVQKMQEEMIKALKGIFDEYSEITSLVTEEIVNVHKEIQMSVDQIDPSTEY 260

Human   261 NNFIDVHRTTAAKEQEIEFDTSLLEENENLQANEIMWNNLTAESLQVMLKTLAEELMQTQQMLLN 325
            |:||||||||||||||||||||||||||||||||||||||||:|||||||||||||.|||||||:
  Rat   261 NDFIDVHRTTAAKEQEIEFDTSLLEENENLQANEIMWNNLTADSLQVMLKTLAEELTQTQQMLLH 325

Human   326 KEEAVLELEKRIEESSETCEKKSDIVLLLSQKQALEELKQSVQQLRCTEAKFSAQKELLEQKVQE 390
            ||.||||||||||||||||.|||||||||.|||||||||||||||||||||.:||||||||||||
  Rat   326 KEAAVLELEKRIEESSETCAKKSDIVLLLGQKQALEELKQSVQQLRCTEAKCAAQKELLEQKVQE 390

Human   391 NDGKEPPPVVNYEEDARSVTSMERKERLSKFESIRHSIAGIIRSPKSALGSSA-LSDMISISEKP 454
            ||||||||||||||||||||||||||||||||||||||||||:||||.||||. |||:||:.|||
  Rat   391 NDGKEPPPVVNYEEDARSVTSMERKERLSKFESIRHSIAGIIKSPKSVLGSSTQLSDVISVGEKP 455

Human   455 LAEQDWYHGAIPRIEAQELLKKQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYRFEGT 519
            |||.|||||||||||||||||:||||||||||||||||||||||||||||||||:|||:||||||
  Rat   456 LAEHDWYHGAIPRIEAQELLKQQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQFVDNLYRFEGT 520

Human   520 GFSNIPQLIDHHYTTKQVITKKSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEVYKGTLKD 584
            ||||||||||||:.|||||||||||||||||||||||:|:||||.||||||||||||||||||||
  Rat   521 GFSNIPQLIDHHFNTKQVITKKSGVVLLNPIPKDKKWVLNHEDVSLGELLGKGNFGEVYKGTLKD 585

Human   585 KTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFL 649
            ||.|||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||:||
  Rat   586 KTPVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVPGGDFLSFL 650

Human   650 RRKKDELKLKQLVKFSLDAAAGMLYLESKNCIHRLCEGKGEMKETSNLGDLAARNCLVGENNVLK 714
            |::||||||||||:||||.||||||||.||||||               |||||||||||||.||
  Rat   651 RKRKDELKLKQLVRFSLDVAAGMLYLEGKNCIHR---------------DLAARNCLVGENNTLK 700

Human   715 ISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGM 779
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   701 ISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGM 765

Human   780 TNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKELTIIKRKLT 837
            |||||||||||||||||||:|||:|..|||||||||||||||||:|.||||.||:|:|
  Rat   766 TNQQAREQVERGYRMSAPQNCPEEIFTIMMKCWDYKPENRPKFSDLHKELTAIKKKIT 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	XP_011541568.1	F-BAR_Fer	5..238	CDD:153370	220/232 (95%)
		SH2_Fps_family	453..538	CDD:198224	78/84 (93%)
		Pkinase_Tyr	563..829	CDD:285015	234/265 (88%)
		PKc_like	566..831	CDD:304357	234/264 (89%)
Fer	NP_001382687.1	Important for interaction with membranes containing phosphoinositides. /evidence=ECO:0000250	1..300		284/298 (95%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83691428
Domainoid	1	1.000	673	1.000	Domainoid score	I3836
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74300
Inparanoid	1	1.050	1528	1.000	Inparanoid score	I2645
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG47024
OrthoDB	1	1.010	-	-		D14150at314146
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		oto139256
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	LDO	PTHR24418
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1749
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	15.410