DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and frk-1

DIOPT Version :9

Sequence 1:	XP_011541568.1	Gene:	FER / 2241	HGNCID:	3655	Length:	837	Species:	Homo sapiens
Sequence 2:	NP_001369901.1	Gene:	frk-1 / 191635	WormBaseID:	WBGene00001487	Length:	390	Species:	Caenorhabditis elegans

Alignment Length:	404	Identity:	146/404 - (36%)
Similarity:	233/404 - (57%)	Gaps:	37/404 - (9%)

- Green bases have known domain annotations that are detailed below.

Human   436 KSALGSSALSDMISISEKPLAEQDWYHGAIPRIEAQELLKKQGDFLVRESHGKPGEYVLSV---Y 497
            ||:...::::|.|..:|       :|||.:||.:|:..||::||||||::...||:.||::   .
Worm     6 KSSNNDASVTDDIRSAE-------YYHGMVPRQDAEGFLKREGDFLVRKTEQMPGKVVLAMSVRV 63

Human   498 SDGQRRHFIIQY--VDNMYRFEGT-GFSNIPQLIDHHYTTKQVITKKSGVVLLNPIPKDKKWILS 559
            :|...|||::..  ..|.:.||.| ..|.|.:||:.|.|||..|:..||..:..|:.: ..|:::
Worm    64 TDELCRHFMLNMDPTSNKFYFEHTHQESTISELINWHMTTKTPISAASGAKIRRPMER-SPWLIN 127

Human   560 HEDVILGELLGKGNFGEVYKGTLKD--KTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVK 622
            |:.::..:.||:|.||:|:...|..  |..|||||.:.:..:|.:::|::||:::::|.|.::||
Worm   128 HDSIVANKKLGEGAFGDVFIAELDQGGKQEVAVKTMRAEATREARLRFMKEARLMRKYQHKHVVK 192

Human   623 LIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQLVKFSLDAAAGMLYLESKNCIHRLCEG 687
            ||||.....|:.|:||....|..|:.|  ||:::.|.:.::|:.:||.|:.|||...||||
Worm   193 LIGVAIHEHPLMIVMEYCPNGSLLSHL--KKNKVSLIEKLRFTTEAADGIAYLERSKCIHR---- 251

Human   688 KGEMKETSNLGDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRY 752
                       |:||||||:...|.|||||||||..:|  ......|:::||||.|||.:....|
Worm   252 -----------DIAARNCLLSAKNELKISDFGMSDNKD--EIKDETLEKVPIKWLAPETMQEKVY 303

Human   753 SSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQ-VERGYRMSAPQHCPEDISKIMM-KCWDYK 815
            :.::|:|:||:|:||.:|.|..||||:|..|.|.: |...|||..|......::.::. .||...
Worm   304 THKTDIWTFGVLVWEIYSDGAEPYPGLTKIQTRAKIVVNDYRMKMPDGTHPTVADVVTGTCWQKN 368

Human   816 PENRPKFSELQKEL 829
            ||.|.....:.|:|
Worm   369 PEKRSTMDSIHKKL 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	XP_011541568.1	F-BAR_Fer	5..238	CDD:153370
		SH2_Fps_family	453..538	CDD:198224	34/90 (38%)
		Pkinase_Tyr	563..829	CDD:285015	100/269 (37%)
		PKc_like	566..831	CDD:304357	101/268 (38%)
frk-1	NP_001369901.1	SH2_Fps_family	16..107	CDD:198224	37/97 (38%)
frk-1	NP_001369901.1	TyrKc	131..382	CDD:197581	100/269 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H74300
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3524
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D255116at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		mtm5010
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3894
SonicParanoid	1	1.000	-	-		X1749
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.900