DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and kin-14

DIOPT Version :9

Sequence 1:	XP_011541568.1	Gene:	FER / 2241	HGNCID:	3655	Length:	837	Species:	Homo sapiens
Sequence 2:	NP_492004.1	Gene:	kin-14 / 172440	WormBaseID:	WBGene00002198	Length:	418	Species:	Caenorhabditis elegans

Alignment Length:	411	Identity:	152/411 - (36%)
Similarity:	230/411 - (55%)	Gaps:	43/411 - (10%)

- Green bases have known domain annotations that are detailed below.

Human   441 SSALSDMISISEKPLAEQDWYHGAIPRIEAQELLKKQGDFLVR--ESHGKPGEYVLSVYSDGQRR 503
            ||:.|.|...|:......:|:||.:.|.:|.|||.|.|.||:|  |.|||. ..:|||..||:..
Worm    11 SSSTSSMTENSDGQKQNNEWFHGVLQRQDADELLVKPGSFLLRASEVHGKM-SMILSVRHDGKLH 74

Human   504 HFIIQY-VDNMYRFEGTGFSNIPQLIDHHYTTKQVITKKSGVVLLNPIPKDKKWILSHEDVILGE 567
            :..:.. ....:.|||....:|.||:..|.||...|||.|||.|..||.| ..||:|||:||..:
Worm    75 NIAVNSDTGENFWFEGHREKSIDQLVQWHMTTSTPITKTSGVKLKYPIGK-ADWIISHENVIFIK 138

Human   568 LLGKGNFGEVYKGTLKD------KTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLI-- 624
            .||:|.||||   :|.:      |...||||.:..:.::.:..|::||:::::|.||:||::|
Worm   139 KLGEGAFGEV---SLAECEIGGRKVETAVKTMRCQMTRDTRAAFMKEARLMRKYSHPHIVRIIGK 200

Human   625 ---------GVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQLVKFSLDAAAGMLYLESKNC 680
                     |:.....|:.|:||:...|..|:|||:.|.:..|.:.::|.:::|.|:.|||.|.|
Worm   201 IIVKHLPKVGLAVDAHPLMIVMEMCPHGSLLSFLRKNKGKTTLSERLRFCIESADGLAYLEKKQC 265

Human   681 IHRLCEGKGEMKETSNLGDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPE 745
            :||               |:||||||:...:.:||||||:|..:...::..: |.::|:||.|||
Worm   266 LHR---------------DIAARNCLLSITDQIKISDFGLSDDKRTEMHDDT-LDKVPVKWLAPE 314

Human   746 ALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVE-RGYRMSAPQHCPEDISKIMM 809
            .:....||.:||||:||:|:||.::.|..|||||||...|.::. ..|||:.|:..|..||:|.:
Worm   315 VMQDKLYSLKSDVWAFGVLMWEIYADGADPYPGMTNLVTRAKIFCDDYRMTFPETTPPTISEIAL 379

Human   810 K-CWDYKPENRPKFSELQKEL 829
            | ||...|.:|.....:..:|
Worm   380 KQCWAKLPSDRATMKTVHHKL 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	XP_011541568.1	F-BAR_Fer	5..238	CDD:153370
		SH2_Fps_family	453..538	CDD:198224	31/87 (36%)
		Pkinase_Tyr	563..829	CDD:285015	100/284 (35%)
		PKc_like	566..831	CDD:304357	99/283 (35%)
kin-14	NP_492004.1	SH2_Fps_family	26..110	CDD:198224	31/84 (37%)
		Pkinase_Tyr	134..400	CDD:285015	100/284 (35%)
		PTKc	138..401	CDD:270623	99/282 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H74300
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D255116at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		mtm5010
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1749
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.820