DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi4ka and Pi4KIIIalpha

DIOPT Version :9

Sequence 1:NP_001360884.1 Gene:Pi4ka / 224020 MGIID:2448506 Length:2105 Species:Mus musculus
Sequence 2:NP_001259191.1 Gene:Pi4KIIIalpha / 31247 FlyBaseID:FBgn0267350 Length:2154 Species:Drosophila melanogaster


Alignment Length:2219 Identity:993/2219 - (44%)
Similarity:1360/2219 - (61%) Gaps:222/2219 - (10%)


- Green bases have known domain annotations that are detailed below.


Mouse    34 YFNTVLSLARSLAVQRPASLEKVQKLLCMCPVD-FHGIFQLDERRRDAVIALGIFLIESDLQHKD 97
            |..|||.|||.||..:|...:|||.|...||.: ..|:|.||.|.:||||||||:.:|...||:.
  Fly    11 YQRTVLCLARVLAGIQPTPWDKVQTLFRYCPQENAAGVFCLDTRAQDAVIALGIYFLEGGCQHEG 75

Mouse    98 CVVPYLLRLLRGLPKVYWVEESTARK-GRGNLPVAESFSFCLVTLLSDVACRDPSLRDEILEAIL 161
            .:|||||||.:.|||..|::::.:.| .|..:|.||.|||||.|||||:|.:.|..|:||:...:
  Fly    76 QIVPYLLRLAKCLPKAVWIDDARSNKVERVRIPSAEKFSFCLNTLLSDIAAKCPDSREEIILNQV 140

Mouse   162 QVLHVLLGMCQALEIQEKE----YLCKYAIPCLIGISRSFGRYSNSEESLLSKLFPKVSPHSLRI 222
            :.|..|..:.::.......    .|||..:|.|.|::||.|||::::..||.::||   |..|.|
  Fly   141 ETLSALANIVKSSRDSSSAPPPIILCKATVPLLFGLARSMGRYASNDPPLLCRIFP---PELLPI 202

Mouse   223 PE-----------ELEGVRRRSFND---------FRSILPSNLLTVCQEGTLKRKTSSVSSISQV 267
            .:           ...|....||:.         ||.|:|.::            :.|::.....
  Fly   203 QKGGGRDGTGSSSSASGTCGGSFSSSERLAATHHFRPIIPRSM------------SGSLAQAQNA 255

Mouse   268 SPERGIP-----PPSSPGGSAFHYFEASCLPDGTALEPEYYFSTISSSFS--------ISPLFNG 319
            |.:.|..     .||.|  |...||.....|      ..::|:...|||:        .||...|
  Fly   256 SYDDGRQRCAGGKPSKP--SLHSYFSVPYDP------RTHFFTRYGSSFNQFPNMRVCESPTKGG 312

Mouse   320 --ITYKEFCIPLEMLRELLNLVKKIVEEPVLKSLDAIVAGVMEANPSADLYYTTFSDPLYLTMFK 382
              ..|:....|::.|:.:..:.||::.:..|:.||...:.:...:......|.:||:.|.|.:..
  Fly   313 PRPLYRVPPFPIQHLQTIFAVSKKLLTKDTLEHLDEQASDIFSLHQIKGYCYKSFSETLNLVLVT 377

Mouse   383 MLRDTLYYMKDLPTSFVKEIHDFVLEQFNMSQGELQKILHDADRIHSE------MSPLKLRCQAN 441
            :||:.|.:..||||.|.|::.:||...|...|.|||....|.:|...|      ::..|:...||
  Fly   378 LLRELLQHQVDLPTPFTKDVQEFVKRLFLNGQTELQNKQQDQERERREENGIAVVNKYKVNVMAN 442

Mouse   442 AACVDLMVWAVKDE--------------------QGAENLCIKLSEKLQSKTSSKVIIAHLPLLI 486
            ||||||:|||::||                    :.|:.||.:||:||..:.|.|:::.|:|||:
  Fly   443 AACVDLLVWAIRDETVDVDYNVPSLQNGLQFLLKKEADKLCGRLSQKLNLELSHKIVMDHMPLLM 507

Mouse   487 CCLQGLGRLCERFPVVVHSVTPSLRDFLVIPSPVLVKLYKYHSQYHTVAG-------SDIKISVT 544
            .||:|||:|..:||.:..:....||||||.|||:|.||:.:..|  ::|.       :..||:| 
  Fly   508 VCLEGLGKLAHKFPNIAGTSISYLRDFLVAPSPILGKLHDHAMQ--SLAQQKKEKELTPFKIAV- 569

Mouse   545 NEHSES-TLNVLPGKKNQP----------SMYEQLRDIAIDNICRCLKAGLTVDPVIVEAFLASL 598
             :||:| |..|:.|...:|          :.:|.|||.||:|:...|:|..|:|...|.|.:|::
  Fly   570 -QHSDSRTAVVIYGDNQKPPGSGTGRSGHAAFESLRDAAIENLSIALRAAHTLDQFCVPALVANV 633

Mouse   599 SNRLYISQESDKD-------AHLIPDHTIRALGHIAVALRDTPKVMEPILQILQQKFCQPPSPLD 656
            ||||:.:::|..:       ::|:..:.|..|||:||||:||.|..:.|||...|:||:.||..:
  Fly   634 SNRLFTAEKSGSESQGECHKSNLVSLNIIVMLGHVAVALKDTSKTTQNILQFFIQRFCKVPSEQN 698

Mouse   657 VLIIDQLGCLVITG-NQYIYQEVWNLFQQISVKASSVVYSATKDYKDHGYRHCSLAVINALANIA 720
            .||:|||||::|:. ..:::.|:..:|.:::|:::|:.|::..:::.. :.|.|.||:|||.|||
  Fly   699 ALIVDQLGCMIISQCETHVFDEIMKMFSRVTVQSASLAYTSDPEHRKQ-FHHVSDAVVNALGNIA 762

Mouse   721 ANIQEEHLVDELLMNLLELFVQLGLEGKRASERASEKGP-ALKASSSAGNLGVLIPVIAVLTRRL 784
            ||||.:..:.|||..|||||||:||:|    ||:.:..| |.||||.|||||:||||||||.|||
  Fly   763 ANIQGDAEMLELLGKLLELFVQIGLDG----ERSYDNTPGAQKASSRAGNLGMLIPVIAVLVRRL 823

Mouse   785 PPIKEAKPRLQKLFRDFWLYSVLMGFAVEGSGLWPEEWYEGVCEIATKSPLLTFPS--KEPLRSV 847
            ||||..:.||.|||:|||.|.|:|||.  .:.|||.:||:||.:||.|||||...:  |..:|. 
  Fly   824 PPIKNPRQRLHKLFKDFWAYCVVMGFT--NARLWPADWYQGVQQIAAKSPLLISQTAHKSDMRE- 885

Mouse   848 LQYNSAMKNDTVTPAELSELRSTIINLLDPPPE-VSALINKLDFAMSTYLLSVYRLEYMRVLRST 911
            |.|..|:|:|:|     :||||.|:.||:...: |:..||||.||..|||||||.||.:||..:.
  Fly   886 LNYTLAIKSDSV-----NELRSQILVLLEHSSDNVATAINKLSFAQCTYLLSVYWLEMLRVENAD 945

Mouse   912 DPDRFQVMFCYFEDKAIQKDKSGMMQCVIAVADKVFDAFLNMMAEKAKTKENEEELERHAQFLLV 976
            :|....:| .|..|.|:|:||:|:.|||..|||:||:.|.|::  .|..:..|:.||..|..|||
  Fly   946 EPSLEPIM-SYLCDTALQRDKTGIWQCVKCVADQVFEKFRNVL--YAHDEIREKVLESQATLLLV 1007

Mouse   977 NFNHIHKRIRRVADKYLSGLVDKFPHLLWSGTVLKTMLDILQTLSLSLSADIHKDQPYYDIPDAP 1041
            .||||||.|:.|||:|||.|||:||||||:..||..||||||.|:.|||.|.:::.|...:...|
  Fly  1008 YFNHIHKPIQMVADQYLSFLVDRFPHLLWNRRVLWCMLDILQLLAYSLSLDPNEETPTLRVVSTP 1072

Mouse  1042 YRITVPDTYEARESIVKDFAARCGMILQEAMKWAPTVTKSHLQEYLNKHQNWVSGLSQHTGLAMA 1106
            |.:.:.|:..|||..:||||.||..|:.|||||||..|:||||||.|:....|  |:.|:|||:|
  Fly  1073 YTLQLMDSLPARELRLKDFADRCQGIVNEAMKWAPRSTRSHLQEYPNQIPTPV--LAHHSGLALA 1135

Mouse  1107 TESILHFAGYNKQNTTLGATQLTERPACVKKDYSNFMASLNLRNRYAGEVHGMIRFSGATGQMSD 1171
            .:|::   ..:.|:|    ..:::||:||..|...|::.|.||::||||:.|::      ..:|:
  Fly  1136 FDSVV---SSSAQHT----GTMSKRPSCVNSDTPRFVSVLCLRSKYAGEISGLL------SVLSE 1187

Mouse  1172 LNK-----MMVQDLITALDHSHPQHYTQAMFKLTAMLISSKDCDPQLLHHLCWGPLRMFNEHGME 1231
            .:|     .:|.|:..|........:..|:::.||.||...:...:|||.:....|.:|.|..||
  Fly  1188 KDKAGLADRLVSDVWEACAEKSDARHRGALWRATAYLIICSEISRKLLHAVASSQLELFTESAME 1252

Mouse  1232 TALACWEWLLAGKNGVEVPFMREMAGAWHMTVEQKFGLFSVETKEADPLAASEASQPRPCPPEVT 1296
            ||:.||:|:|..:..:|:.|::||..||..|.|::.|||:.||:...||||.|..:....|..:.
  Fly  1253 TAVECWQWVLTARQDLELCFIQEMVSAWQTTFEKRMGLFAWETEVTHPLAAYEGCKLVSKPILIA 1317

Mouse  1297 PHYIWIDFLVQRFEIAKYCSSDQVEIFSSLLQRSMSLNIGGARGSMNRHVAAIGPRFKLLTLGLS 1361
            ||.||:..|.:..:.||||:.|:||:|..||.|.:.:.   .....||.|:.:|.|||||..|||
  Fly  1318 PHLIWLQLLSEMVDTAKYCNRDKVEMFCLLLHRCLPVL---KSSKQNRQVSTVGCRFKLLQCGLS 1379

Mouse  1362 LLHADVVPNATIRNVLREKIYSTAFDYFSCPPKFPTQGEKRLREDISIMIKFWTAMFSDKKYLTA 1426
            ||..:.:|.:..||:|||:|||.|.|||..||..|.|..::|.|||.|::|||..|.|:||:|..
  Fly  1380 LLQGNTIPKSLSRNILRERIYSNALDYFCGPPTCPNQSREQLLEDIMILLKFWQTMRSEKKHLVT 1444

Mouse  1427 SQLVPPD------------------------------NQDTRS----------NLDITVGSRQQA 1451
            |::...|                              |..|||          .:.:..|.   :
  Fly  1445 SEVGDYDLTNASVSSTQMLAVRNNPETASLISGGGLVNDYTRSMSASGNAVGMGMGVAGGG---S 1506

Mouse  1452 TQGWINTYPLSSGMSTISKKSGMSKKTN-RGSQLHKYYMKRRTLLLSLLATEIERLITWYNPLSA 1515
            :.||.||.|.|:  ||:||:|..||:.. :.....|.|||:|.|:|.|||.|:|.|||||||.|.
  Fly  1507 SSGWYNTIPHST--STLSKRSNRSKRLQYQKDSYDKDYMKKRNLILELLAVELEFLITWYNPNSL 1569

Mouse  1516 PELELDQAGENSVANWRSKYISLSEKQWKDNVNLAWSISPYLAVQLPARFKNTEAIGNEVTRLVR 1580
            |:|.:  .||..:..||::  ......|:|...|||..:|.|||.||.|.||.|.|..||:|||.
  Fly  1570 PDLIV--PGEEQITEWRNR--PYKSTVWRDYARLAWCYNPALAVFLPQRIKNAEIIDEEVSRLVC 1630

Mouse  1581 LDPGAVSDVPEAIKFLVTWHTIDADAPELSHVLCWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVL 1645
            .||.||..:|||:|:|.|...:..::|:|.::|.|:|..|...|:|||..||.|||||||.||.|
  Fly  1631 SDPIAVCHIPEALKYLCTTKNLLQESPDLVYILSWSPVTPIQALAYFSRQYPSHPLTAQYAVKTL 1695

Mouse  1646 RSFPPDAILFYIPQIVQALRYDKMGYVREYILWAAAKSQLLAHQFIWNMKTNIYLDEEGHQKDPD 1710
            .|:|.:::|.||||:|||||:|.||||.|:|...:.:||::|||.||||:||:|:||:...|||:
  Fly  1696 SSYPAESVLPYIPQLVQALRHDTMGYVVEFIKNISRRSQIVAHQLIWNMQTNMYMDEDQQHKDPN 1760

Mouse  1711 IGDLLEQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDERKKACLSALSEVKVQP 1775
            :.:.|:||.:.|..|.||.||.||:||||||.|||.||..|:.:.||.|||.|||:|||.:|||.
  Fly  1761 LYEALDQLSQSIIASFSGAAKRFYEREFDFFGKITAVSGEIRSFAKGIERKNACLAALSRIKVQG 1825

Mouse  1776 GCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLQCRSDAEDECFSQEA 1840
            ||||||||||:||||||.|||||||||||||||:|:|.|||::|||...::..::..    ||| 
  Fly  1826 GCYLPSNPEAMVLDIDYSSGTPMQSAAKAPYLARFRVYRCGITELETRAMEVSNNPN----SQE- 1885

Mouse  1841 DGKKI----CWQAAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIEC 1901
            |.|..    .|||||||||||.||||||||:|.:||||||.||||||:|||||||||||||||||
  Fly  1886 DAKMTLGVESWQAAIFKVGDDVRQDMLALQVITIFKNIFQQVGLDLFLFPYRVVATAPGCGVIEC 1950

Mouse  1902 IPDCTSRDQLGRQTDFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNI 1966
            :|:..||||||||||.|:.:||..||||||:..||.||.||::|||||||:.:||||||||||||
  Fly  1951 VPNAKSRDQLGRQTDSGLSEYFQHQYGDESSKEFQAARANFVKSMAAYSLIGYLLQIKDRHNGNI 2015

Mouse  1967 MLDKKGHIIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVR 2031
            |:||.|||||||||||||||||||:|:|||:||||||||||||||::..||||.|:||:.:||||
  Fly  2016 MIDKDGHIIHIDFGFMFESSPGGNIGFEPDMKLTDEMVMIMGGKMDSPAFKWFCELCVQAFLAVR 2080

Mouse  2032 PYMDAVVSLVTLMLDTGLPCFRGQTIKLLKHRFSPNMTEREAANFIMKVIQNCFLSNRSRTYDMI 2096
            ||.||:||||:|||||||||||||||.|||.||......:|||..::.||:|.:.:.|:||||||
  Fly  2081 PYQDAIVSLVSLMLDTGLPCFRGQTINLLKQRFVATKNNKEAAAHMLAVIRNSYQNFRTRTYDMI 2145

Mouse  2097 QYYQNDIPY 2105
            |||||.|||
  Fly  2146 QYYQNQIPY 2154

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi4kaNP_001360884.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24
PI4Ka 1550..1725 CDD:238443 90/174 (52%)
PI4Kc_III_alpha 1786..2104 CDD:270711 225/321 (70%)
Pi4KIIIalphaNP_001259191.1 PI4Ka 1600..1775 CDD:238443 90/174 (52%)
PI4Kc_III_alpha 1836..2153 CDD:270711 225/321 (70%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167833635
Domainoid 1 1.000 986 1.000 Domainoid score I30
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H11171
Inparanoid 1 1.050 1695 1.000 Inparanoid score I77
Isobase 1 0.950 - 0 Normalized mean entropy S2354
OMA 1 1.010 - - QHG60094
OrthoDB 1 1.010 - - D1147978at2759
OrthoFinder 1 1.000 - - FOG0002854
OrthoInspector 1 1.000 - - oto93771
orthoMCL 1 0.900 - - OOG6_101741
Panther 1 1.100 - - LDO PTHR10048
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4430
SonicParanoid 1 1.000 - - X2686
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1716.750

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