Protein Alignment ALDH3A2 and Aldh-III

DIOPT Version :10

• Sequence 1: NP_001026976.1
• Gene: ALDH3A2 / 224
• HGNCID: 403
• Length: 508
• Species: Homo sapiens
• Sequence 2: NP_724562.2
• Gene: Aldh-III / 45398
• FlyBaseID: FBgn0010548
• Length: 564
• Species: Drosophila melanogaster
• Alignment Length: 490
• Identity: 242/490 - (49%)
• Similarity: 323/490 - (65%)
• Gaps: 18/490 - (3%)

Human     5 VRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEID 69
            ::|.|.||.||::|.:.||.:|||.|.|..:|.|.:|::|:.|||.:.:     ||.:.|  |.:
  Fly    74 LQRARLAFSSGKTRNVSFRRKQLENLLRCYEEHENEIISALEADLRRPK-----QESLIV--ETE 131

Human    70 FM-------LENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIA 127
            ||       |..|.|||.::...|:.:.|:|:..|...|.||||:|||||||..|.:.|:..|||
  Fly   132 FMKNDIRHILFQLDEWVQSEKPPKSFVNMMDDVQIYNDPFGVVLVIGAWNYPLQLLLVPVASAIA 196

Human   128 AGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKI 192
            |||.|:|||||::.|.||.:|.::|:|||.|.|.|:.||..||.|||.||||:|||||:|.||||
  Fly   197 AGNCVVIKPSEIAANCAKFIADVIPKYLDNDCYPVVCGGPSETAELLNQRFDYIFYTGSTRVGKI 261

Human   193 VMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQI 257
            :..||.|:|||.||||||||||||||..|:....:||.|||.:||||||||||||||...:|.:.
  Fly   262 IHAAANKYLTPTTLELGGKSPCYIDKSVDMRTAVKRILWGKLINCGQTCIAPDYILCSKEVQEKF 326

Human   258 VWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVD 322
            :.:.|:.:||:|||||:.|||..|:||..:|:|:|.|::..::|.||..|.:.|:|.||:|.||.
  Fly   327 IVEAKDVLKEWYGENIQSSPDLSRVINANNFQRLLGLMKSGRVAVGGNYDASERFIEPTILVDVK 391

Human   323 PKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGND 387
            ....:|:||||||||||..|::..:||.|||.|||||.:||||:::||:|.....|:|||.:.|:
  Fly   392 ETDPIMEEEIFGPILPIFNVESAYDAIKFINAREKPLVIYVFSNSNKLVKEFRRSTTSGGFSSNE 456

Human   388 VIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLKSLK--REGANKLRYPPNSQSKVDW 450
            .|||..::..||||||.||||.||||:.|:||:|::.||.|.|.  .|..:..||||.|..|...
  Fly   457 TIMHCGVDVLPFGGVGMSGMGRYHGKYGFETFTHKKSCLGKDLSPLGEKLSSARYPPYSDRKGSL 521

Human   451 GKFFLLKRFNKEKLGL--LLLTFLGIVAAVLVKKY 483
            ..|.|.||.....|.|  :|...||:...||...|
  Fly   522 LSFLLRKRRPLPNLHLSHVLAIGLGVGLTVLTNYY 556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ALDH3A2	NP_001026976.1	ALDH_F3AB	5..444	CDD:143450	228/447 (51%)
Aldh-III	NP_724562.2	ALDH_F3AB	72..515	CDD:143450	228/447 (51%)