DRSC/TRiP Functional Genomics Resources

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Protein Alignment Atf7 and kay

DIOPT Version :9

Sequence 1:NP_001296995.1 Gene:Atf7 / 223922 MGIID:2443472 Length:483 Species:Mus musculus
Sequence 2:NP_001027577.2 Gene:kay / 3772082 FlyBaseID:FBgn0001297 Length:755 Species:Drosophila melanogaster


Alignment Length:397 Identity:88/397 - (22%)
Similarity:146/397 - (36%) Gaps:108/397 - (27%)


- Green bases have known domain annotations that are detailed below.


Mouse   168 TLPSPTSVITQAPPSNRQIGSPTGSLPLVMHLANGQTMPMLPGPPVQMPSVISLARPVSMVPNIP 232
            ||.:|    |..|.:.|.|....|.|     |::.||..:.......:|.|:..|..| :...||
  Fly   246 TLTTP----TLTPTTTRNIEDTLGHL-----LSDTQTDRVAGCAGFAVPKVLPNAIDV-LGMGIP 300

Mouse   233 -GIPGPPVNNS-------GSISPSGHPMPSEAKMRLKATLTHQVS----------------SING 273
             |:...|:..:       ||.|...:...::.:|..:...|...|                |:||
  Fly   301 TGVSSLPLQQTFDLSLGQGSESEDSNASYNDTQMNEEQDTTDTSSAHTDSTSYQAGHIMAGSVNG 365

Mouse   274 G-----CGMVVGTASTMVTARPEQNQILIQHPDAPSPAQPQVSPAQPTPSTGGRR-RRTVDEDPD 332
            |     ..::...:|:..:|..           ..|.|....:||:   ..|||| .|:.:..|:
  Fly   366 GGVNNFSNVLAAVSSSRGSASV-----------GSSNANTSNTPAR---RGGGRRPNRSTNMTPE 416

Mouse   333 ERRQRFL--ERNRAAASRCRQKRKLWVSSLEKKAEELTSQNIQLSNEVTLLRNEVAQLKQLLLAH 395
            |.::|.:  |||:.||:|||::|....:.|.::.|:|..:...:..|:.:|.|...||:.||..|
  Fly   417 EEQKRAVRRERNKQAAARCRKRRVDQTNELTEEVEQLEKRGESMRKEIEVLTNSKNQLEYLLATH 481

Mouse   396 K--------------DC-----PVTALQKKTQGYLESPKESSEPTGSPAPVIQHSSASAPSNG-- 439
            :              .|     |...|...:.|...|...:.....|....|....|:..|.|  
  Fly   482 RATCQKIRSDMLSVVTCNGLIAPAGLLSAGSSGSGASSHHNHNSNDSSNGTITGMDATLNSTGRS 546

Mouse   440 ---LSVRSAAEAVATSVLTQMASQRTE-------------------LSMPIQS---HV----IMT 475
               |.::.||.  ..|:|..:..:..:                   :::|..|   ||    |:|
  Fly   547 NSPLDLKPAAN--IDSLLMHIKDEPLDGAIDSGSSLDQDGPPPSKRITLPPMSTMPHVHLSTILT 609

Mouse   476 PQSQSAG 482
            |...|:|
  Fly   610 PTGASSG 616

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Atf7NP_001296995.1 Transactivation domain. /evidence=ECO:0000250 1..285 31/145 (21%)
C2H2 Zn finger 9..31 CDD:275370
GCN4_cent 47..84 CDD:213399
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 81..140
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 299..337 11/38 (29%)
bZIP_ATF2 334..394 CDD:269835 20/61 (33%)
coiled coil 334..394 CDD:269835 20/61 (33%)
Basic motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978 334..354 9/21 (43%)
Leucine-zipper. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978 360..388 6/27 (22%)
kayNP_001027577.2 bZIP_Fos 420..481 CDD:269869 20/60 (33%)
coiled coil 421..480 CDD:269869 20/58 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R103
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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