Protein Alignment GPC4 and dlp

DIOPT Version :9

• Sequence 1: NP_001439.2
• Gene: GPC4 / 2239
• HGNCID: 4452
• Length: 556
• Species: Homo sapiens
• Sequence 2: NP_524071.2
• Gene: dlp / 39596
• FlyBaseID: FBgn0041604
• Length: 765
• Species: Drosophila melanogaster
• Alignment Length: 599
• Identity: 201/599 - (33%)
• Similarity: 307/599 - (51%)
• Gaps: 99/599 - (16%)

Human    27 SKSCSEVRRLYVSKGFNKNDAPLHEINGDHLKIC--PQGSTCCSQEMEEKYSLQSKDDFKSVVSE 89
            |.:||.|..::.::|.:..:.|....|...|:.|  |...|||:..||.:.::||:...:....:
  Fly    77 SPNCSAVTHIFQARGIDAIEIPQKPSNERVLRYCESPSVGTCCTYNMETRMAMQSRQQLEGHTKD 141

Human    90 QCNHLQAVFASRYKKFDEFFKELLENAEKSLNDMFVKTYGHLYMQNSELFKDLFVELKRYYVVGN 154
            |.:.:..:..|:..||.:.|..||:.:....|.||::|||.:|.:||.:|.|||.||:.|:..|.
  Fly   142 QISRMSGILGSKATKFKDIFTALLKESRTQFNSMFIRTYGVIYERNSYVFSDLFKELETYFANGR 206

Human   155 VNLEEMLNDFWARLLERMFRLVNSQYHFTDEYLECVSKYTEQLKPFGDVPRKLKLQVTRAFVAAR 219
            |:|.|:::.|:..|.::||.::|:||.|.:.|:.|||::.::||||||||.||.:|:.|:|||.|
  Fly   207 VDLLEVMDKFFNTLYQKMFTVLNTQYTFDENYMRCVSEHMKELKPFGDVPDKLSVQIKRSFVATR 271

Human   220 TFAQGLAVAGDVVSKVSVVNPTAQCTHALLKMIYCSHCRGLVTVKPCYNYCSNIMRGCLANQGDL 284
            |:.|.|..|.:|..||..|...|.||.||.||.:|..|:| .|.|||.|||.|:::|||..|.:.
  Fly   272 TYGQALTTASEVAKKVLNVRLNADCTGALTKMQHCGACKG-YTEKPCTNYCVNVIKGCLHYQHEF 335

Human   285 DFEWNNFIDAMLMVAERLEGPFNIESVMDPIDVKISDAIMNMQDNSVQVSQKVFQGCGPPK---- 345
            |.||.||..||..|||||.|.|||..|::|:::|||:||||.||:...::.:||||||.||
  Fly   336 DSEWENFAMAMDKVAERLLGSFNIVMVVEPLNIKISEAIMNFQDSGQDITNRVFQGCGRPKLKKM 400

Human   346 ------------------PLPAGR--ISRSISESAFSARFRPHHPEERPTTA-------AGTS-- 381
                              |:.|..  |..::.|:......|...|..:.|:|       .|.|
  Fly   401 KRSISPKLQGVQILNARSPVEADTLDIDETLDEAIVLRERRAAEPGSQETSAQQSQEQGVGKSGN 465

Human   382 ----------------------------------------------LDRLVTDVKEKLKQAKKFW 400
                                                          |||:|.|:::::|..||||
  Fly   466 GGGGGGGNNRRQQQRRKQQQQRRKQQNNRDDNDDDDNESGGGREPILDRIVRDIRQRVKDYKKFW 530

Human   401 SSLPSNVCNDERMAAGNGNEDDCWNGKGKSRYLFAVTGNGLANQGNNPEVQVD--TSKPDILILR 463
            |:||.:||::|.:|:.:..:..||||....||:.::|    ...|:|||...:  ::|....:..
  Fly   531 SNLPHSVCSNEDIASSSDVDGMCWNGHTIDRYMHSIT----TEHGSNPEFTGNPASTKQTAQMAS 591

Human   464 QIMALRVMTSKMKNAYNGNDVDFFDISD---ESSGEGSGSGCEYQQCPSEFDYNATDHAGKSANE 525
            |:..|:.....::|||||.||::.:..:   ..||.|||||       ||.|.:..:.:|....|
  Fly   592 QLSHLKNAIVHLRNAYNGQDVEWSEQEELPYAGSGAGSGSG-------SEDDEDDDEGSGLGPFE 649

Human   526 KADSAGV-RPGAQA 538
            .:....| ||...|
  Fly   650 PSHKPDVERPSVDA 663

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GPC4	NP_001439.2	Glypican	26..551	CDD:307347	201/599 (34%)
dlp	NP_524071.2	Glypican	79..613	CDD:279494	183/538 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	286	1.000	Domainoid score	I1604
eggNOG	1	0.900	-	-		E1_KOG3821
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H55582
Inparanoid	1	1.050	373	1.000	Inparanoid score	I2117
Isobase	1	0.950	-	0	Normalized mean entropy	S6660
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D275653at33208
OrthoFinder	1	1.000	-	-		FOG0000903
OrthoInspector	1	1.000	-	-		otm41759
orthoMCL	1	0.900	-	-		OOG6_105830
Panther	1	1.100	-	-	LDO	PTHR10822
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X519
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.780