Protein Alignment Fmnl3 and dia

DIOPT Version :9

• Sequence 1: NP_035841.1
• Gene: Fmnl3 / 22379
• MGIID: 109569
• Length: 1028
• Species: Mus musculus
• Sequence 2: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Alignment Length: 1155
• Identity: 285/1155 - (24%)
• Similarity: 482/1155 - (41%)
• Gaps: 285/1155 - (24%)

Mouse     2 GNLESTDGGP----------------GEPPSVPLLLPPGKTPMPE------PCELEERFALVLSS 44
            |.|:|..|.|                |.|.|....:.||.....:      ..||:.:|..::..
  Fly    20 GLLDSLFGRPSKSKGGTISSGTLAHGGRPVSADNYVVPGVEDFEQYIQQLSVAELDAKFLEIIED 84

Mouse    45 MNLPPDKARLLRQYDNEKKWDLI------------CDQERFQVKNPPHTYIQKLQSFLDPNVTRK 97
            ||:|.||...|.....|::..:|            ....||:   .|..|::.||:  ..:.|.|
  Fly    85 MNIPKDKREPLLAKSKEERQKMIMWHLKGKNSLERSANSRFE---KPIDYVEYLQN--GEHSTHK 144

Mouse    98 KFRRRVQESTKVLRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESGDD 162
            .:        :.:..|.::|.:|.|.|::|                        |...|:
  Fly   145 VY--------QCVESLRVALTSNPISWIKE------------------------FGVAGI----- 172

Mouse   163 GAFDKLRSWSRSIEDLQPPNALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVC 227
            |..:||                       ||||                 ||:  .|.:......
  Fly   173 GTIEKL-----------------------LARS-----------------KNN--ASYEKIEFEA 195

Mouse   228 ILCLRAIMNYQYGFNLVMS-HPHA-VNEIALSLNNKNPRTKALVLELLAAVCLV--RGGHEIILA 288
            |.||:||||..:|.|:|:: ..|: |..:|.||:.:.|:|....|:|||:.|:|  |.|:|.:|.
  Fly   196 IRCLKAIMNNTWGLNVVLNPDQHSVVLLLAQSLDPRKPQTMCEALKLLASFCIVYERNGYEKVLR 260

Mouse   289 AFDNFKEVC-KELHRFEKLME-YFRNEDSNIDFMVAC--MQFINIVVHSVEDMNFRVHLQYEFTK 349
            |........ |...||..::: .|.::..:....:||  :.|||.:.::..|:|||:||:.|..:
  Fly   261 AITTIAATSFKASERFRPIVDALFASDQQDPKRDLACHSLIFINTLTNTPTDLNFRLHLRCEIMR 325

Mouse   350 LG----LEEFLQKSRHTESEKLQVQIQAY--------------LDNV----------FDV-GGLL 385
            :|    |:||.:....:.:|.||...:.:              .|||          ||| ..|:
  Fly   326 MGLYDRLDEFTKIVEASNNENLQQHFKIFNEIREDDFEEFVQRFDNVTFNMDDATDCFDVLKNLV 390

Mouse   386 EDAETKNVALEKVEEL-----------------EEHVSHLT--EKLLD--LENENM-MRVAELEK 428
            .|..::...|..::.|                 ||.:|.:.  :...|  .||.|. :..:.|..
  Fly   391 TDTTSEPYFLSILQHLLYIRDDFYFRPAYYQLIEECISQIVFHKGYCDPNFENRNFNIDTSLLLD 455

Mouse   429 QLLQREKELESIK-ETYENTSNQVHTLRRLIKEKEEAFQRRCHLEPSARGLESMGGEALARVGPT 492
            .::::.|..||.: |.||....|:.:      .|:||..:..|||...:.:|:.|   :|...|.
  Fly   456 DIVEKAKAKESKRSEEYEKKIEQLES------AKQEAEAKAAHLEEKVKLMEANG---VAAPSPN 511

Mouse   493 ELTEGIPPSDLDLLAPAPPTEETLPLPPPPAP------PLPPPPPPLPDKC-------------- 537
            :|    |..::.:..|.|......|.||||.|      |.||||||:|.:.
  Fly   512 KL----PKVNIPMPPPPPGGGGAPPPPPPPMPGRAGGGPPPPPPPPMPGRAGGPPPPPPPPGMGG 572

Mouse   538 PPAPPLPG--------------AAPSV-VLTVGLSAIR---IKKPIKTKFRLPVFNWTALKPNQI 584
            ||.||:||              ..|.| ||..||...:   :|.|:|..      ||.|:.|.::
  Fly   573 PPPPPMPGMMRPGGGPPPPPMMMGPMVPVLPHGLKPKKKWDVKNPMKRA------NWKAIVPAKM 631

Mouse   585 NGTVF-SELDDEKILEDLDLDRFEELFKT----KAQGPALDLICSKNKTAQKAASKVTLLEANRA 644
            :...| .:..::|:.:|..|......|.:    |.|..|:|    |..|..|....:.:|::..|
  Fly   632 SDKAFWVKCQEDKLAQDDFLAELAVKFSSKPVKKEQKDAVD----KPTTLTKKNVDLRVLDSKTA 692

Mouse   645 KNLAITLRKAGR--SAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEEL 707
            :||||.|..:.:  |.|:|...:...|...|..:.::.|:::||....:|.|::.:.:.:||..:
  Fly   693 QNLAIMLGGSLKHLSYEQIKICLLRCDTDILSSNILQQLIQYLPPPEHLKRLQEIKAKGEPLPPI 757

Mouse   708 AAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILA 772
               ::|.....:::||:.|:..:.|...:.|.:|.:.|.:.|..||...:::|:|..::||:||.
  Fly   758 ---EQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSKILELILL 819

Mouse   773 LGNYMNS-SKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPELANFWQELHFVEKA 836
            ||||||| ||..|.:||::..|..|.:||..|.|.||||::|..|::|:|:..||:.:|..|.||
  Fly   820 LGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALNFYDDLSHVNKA 884

Mouse   837 AAVSLENVLLDVKELGRGMELIRRECSIHDN-----------SVLRNFLSTNEGKLDKLQRDAKT 890
            :.|:::.:...::::...::.:  |..:.:|           .|:..|......::|.|.:....
  Fly   885 SRVNMDAIQKAMRQMNSAVKNL--ETDLQNNKVPQCDDDKFSEVMGKFAEECRQQVDVLGKMQLQ 947

Mouse   891 AEEAYNAVVRYFGESPKTTPPSVFFPVFVRF-----------IRSYKEAEQENEARKKQEEVMRE 944
            .|:.|..:..|:...|.......||.....|           :|..:|.|::...::.:|:..||
  Fly   948 MEKLYKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAAHNDNVRVREELEKKRRLQEAREQSARE 1012

Mouse   945 KQLAQEAKK--LDAKTPSQRNKWQQQELIAEL--------RRRQAKEHRP 984
            :|..|:.||  :|...| |..:.....|:..|        |.|||:..||
  Fly  1013 QQERQQRKKAVVDMDAP-QTQEGVMDSLLEALQTGSAFGQRNRQARRQRP 1061

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fmnl3	NP_035841.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28		10/41 (24%)
		Drf_GBD	26..278	CDD:283920	58/271 (21%)
		Drf_FH3	281..472	CDD:283917	56/246 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	493..541		20/67 (30%)
		FH2	561..926	CDD:280362	102/394 (26%)
dia	NP_001246113.1	Drf_GBD	66..248	CDD:283920	58/265 (22%)
		Drf_FH3	253..453	CDD:283917	44/199 (22%)
		FH2	608..983	CDD:280362	101/389 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940