Protein Alignment Was and WASp

DIOPT Version :9

• Sequence 1: NP_033541.1
• Gene: Was / 22376
• MGIID: 105059
• Length: 520
• Species: Mus musculus
• Sequence 2: NP_001263045.1
• Gene: WASp / 43402
• FlyBaseID: FBgn0024273
• Length: 527
• Species: Drosophila melanogaster
• Alignment Length: 575
• Identity: 202/575 - (35%)
• Similarity: 261/575 - (45%)
• Gaps: 129/575 - (22%)

Mouse    17 GPAVQQNIPSNLLQDHENQRLFELLGRKCWTLATTVVQLYLALPPGAEHWTMEHCGAVCFVKDNP 81
            ||..:.|..|.||...||:.:|:|||:||.||.|.|||:|........||...|.|.||||||:.
  Fly    10 GPRAKVNAASTLLTQEENEAVFKLLGKKCQTLNTAVVQIYKTEGSAHAHWKKRHTGVVCFVKDSA 74

Mouse    82 QKSYFIRLYGLQAGRLLWEQELYSQLVYLTPTPFFHTFAGDDCQVGLNFADESEAQAFRALVQEK 146
            .:|||:|.|.|....|:||.|:|..:..:...||..||.|.|..|||||..|.|..:|..:|...
  Fly    75 IRSYFMRAYCLIKNELIWEHEIYDGMEVVKSRPFLLTFEGSDGHVGLNFVSEEECDSFFRIVDAT 139

Mouse   147 IQKRNQRQSGER---RQLPPPPAPINEERRGGLPPVPPHPGGDHGGPSGGPLSLGLVTVD---IQ 205
            |:.||:::..:|   :....|.||:.:.:|.  |..||            |:..||.:.|   ::
  Fly   140 IETRNRKRQEKRNRQKSQQAPNAPLPQVQRE--PARPP------------PMQGGLSSTDGVQLR 190

Mouse   206 NPDITSSRYRGLPAP-------------GPGPTDKKRSGKKKISKADIGAPSGFKHVSHVGWDPQ 257
            |..|.|......|||             |....||||    |::||||..|:.|.|:||||||.|
  Fly   191 NNKINSVTLTPAPAPAQSKNFLSSSFGLGNNAKDKKR----KVTKADISRPTNFVHLSHVGWDAQ 251

Mouse   258 NGFDV--NNLDPDLRSLFSRAGISEAQLTDAETSKLIYDFIEDQGGLEAVRQ---EMRRQEPLPP 317
            .|||:  |..|..|...|.:||:||.:|.|.:|...|||||:....|.:|:|   |...:...|.
  Fly   252 KGFDLAGNENDEVLNEFFVKAGVSEVELKDRDTRAFIYDFIQSNNVLASVKQYSVESPTETAAPM 316

Mouse   318 PPPPCRGGGGGGGGGGGGGGGGGGQPLRPPVVGSNKGRSGPLPPVPMGGAPPPPTP-------RG 375
            |||                     .|.|.|    :.|.....||:|....|||..|       |.
  Fly   317 PPP---------------------VPTRHP----SNGNQRTAPPLPPARQPPPAVPVTVPGAARA 356

Mouse   376 PPPPGRGGPPPPPPPATGRSGPPPPPL--PGAGGPPAPPPPP---PPPPPPPCP-GSGPA----- 429
            ||||.|     |||.:|   .|||||:  |....||.|||||   |||||||.| |..|.
  Fly   357 PPPPNR-----PPPIST---APPPPPVSAPVVAPPPPPPPPPAAVPPPPPPPMPVGEIPVITTTH 413

Mouse   430 PPPLPPTPVSGGSPAPGGGRGALLDQIRQGIQLNK------TPGA------LENSVQQ----PPA 478
            .|.....|.:..:|.|   |.||:|.||:|.||.|      :.|:      |...::|    .||
  Fly   414 APTQAARPAAPAAPDP---RNALMDAIRKGTQLKKVDTTALSTGSGDSRSDLMKDIRQGTVLKPA 475

Mouse   479 QQSE--------------GLVGALMHVMQKRSRVIHSSDEGEDQTGEDEEDDEWD 519
            ::.|              .|..||...:..|...|||.   ||:|...:.:.|||
  Fly   476 KERELGSQRNSDSGAGTDALADALRRALAARGNAIHSD---EDETESSDNEGEWD 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Was	NP_033541.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		2/5 (40%)
		WH1	38..147	CDD:144235	49/108 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	148..247		31/117 (26%)
		PBD	239..295	CDD:279166	28/57 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	307..520		83/264 (31%)
WASp	NP_001263045.1	WH1	31..140	CDD:144235	49/108 (45%)
		PBD	233..291	CDD:279166	28/57 (49%)
		WH2	<433..453	CDD:280384	8/19 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I6828
eggNOG	1	0.900	-	-		E1_KOG3671
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	282	1.000	Inparanoid score	I2865
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55182
OrthoDB	1	1.010	-	-		D1407277at2759
OrthoFinder	1	1.000	-	-		FOG0001481
OrthoInspector	1	1.000	-	-		oto92275
orthoMCL	1	0.900	-	-		OOG6_104030
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2175
SonicParanoid	1	1.000	-	-		X2034
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.770