DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vrk1 and CkIalpha

DIOPT Version :9

Sequence 1:	NP_001351296.1	Gene:	Vrk1 / 22367	MGIID:	1261847	Length:	440	Species:	Mus musculus
Sequence 2:	NP_001162737.1	Gene:	CkIalpha / 32221	FlyBaseID:	FBgn0015024	Length:	337	Species:	Drosophila melanogaster

Alignment Length:	337	Identity:	92/337 - (27%)
Similarity:	153/337 - (45%)	Gaps:	51/337 - (15%)

- Green bases have known domain annotations that are detailed below.

Mouse    43 IGQGGFGCIYLADTNSSKPVGSDAPCVVKVEPSD--NGPLFTELKFYQRAAKPEQIQKWIRTHKL 105
            ||.|.||.|||     ...:.|.....:|:|.:.  :..|..|.|.|:..:..
  Fly    26 IGSGSFGDIYL-----GMSIQSGEEVAIKMESAHARHPQLLYEAKLYRILSGG------------ 73

Mouse   106 KYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHE 170
              :|.|:.    .|....|::..::||..|..|:.::....:.|:.||||.|..:::..|||||.
  Fly    74 --VGFPRI----RHHGKEKNFNTLVMDLLGPSLEDLFNFCTRHFTIKTVLMLVDQMIGRLEYIHL 132

Mouse   171 HEYVHGDIKASNLLLS---HKNPDQVYLVDYGLAYRYCPDGV--HKEYKEDPKRCHDGTLEFTSI 230
            ..::|.|||..|.|:.   |.|  :::|:|:|||.::.....  |..|:||...  .||..:.||
  Fly   133 KCFIHRDIKPDNFLMGIGRHCN--KLFLIDFGLAKKFRDPHTRHHIVYREDKNL--TGTARYASI 193

Mouse   231 DAHKGVAPSRRGDLEILGYCMIQWLSGCLPWED---NLKDPNYVRDSKIRYRDNVAALMEKCFPE 292
            :||.|:..|||.|:|.|||.|:.:..|.|||:.   |.|...|.:.|:.:....:..|   |
  Fly   194 NAHLGIEQSRRDDMESLGYVMMYFNRGVLPWQGMKANTKQQKYEKISEKKMSTPIEVL---C--- 252

Mouse   293 KNKPGEIAKYMESVKLLEYTEKPLYQNLRDILLQGLKAIGSKDDGKLDFSAVE--------NGSV 349
            |..|.|.:.|:...:.|.:.|:|.|..||.:.....:.:..:.|...|::.::        |.::
  Fly   253 KGSPAEFSMYLNYCRSLRFEEQPDYMYLRQLFRILFRTLNHQYDYIYDWTMLKQKTHQGQPNPAI 317

Mouse   350 KTRPASKKRKKE 361
            ......|.::|:
  Fly   318 LLEQLDKDKEKQ 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vrk1	NP_001351296.1	STKc_VRK1	26..326	CDD:271024	87/292 (30%)
Vrk1	NP_001351296.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	379..440
CkIalpha	NP_001162737.1	PKc_like	19..284	CDD:304357	87/290 (30%)
CkIalpha	NP_001162737.1	Pkinase_Tyr	23..284	CDD:285015	87/290 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810