DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps45 and Vps45

DIOPT Version :9

Sequence 1:	NP_038869.1	Gene:	Vps45 / 22365	MGIID:	891965	Length:	570	Species:	Mus musculus
Sequence 2:	NP_649909.1	Gene:	Vps45 / 41153	FlyBaseID:	FBgn0261049	Length:	574	Species:	Drosophila melanogaster

Alignment Length:	570	Identity:	309/570 - (54%)
Similarity:	423/570 - (74%)	Gaps:	20/570 - (3%)

- Green bases have known domain annotations that are detailed below.

Mouse     1 MNVVFAVKQYISKMIEDSGPGMKVLLMDKETTGIVSMVYTQSEILQKEVYLFERIDS-QNREIMK 64
            ||::..:|.||.||..:||||||::|:|||||.|:||.::||::||:|||||||:|| ::.|.:|
  Fly     1 MNLISGIKLYIEKMCSESGPGMKIILLDKETTSIISMAFSQSDMLQREVYLFERLDSGRSNERLK 65

Mouse    65 HLKAICFLRPTKENVEYLIQELRRPKYSIYFIYFSNVISKSDVKSLAEADEQEVVAEVQEFYGDY 129
            :||.|.|:||||:|::.|..|||.||||.|:|||||:|.::|:|.|||.||.|.|.||:|.|.||
  Fly    66 YLKCIVFIRPTKQNIQLLANELRNPKYSAYYIYFSNIIPRTDIKYLAECDESESVREVKELYADY 130

Mouse   130 IAVNPHLFSLNILGCCQGRNWDPAQLSRTTQGLTALLLSLKKCPMIRYQLSSEAAKRLGECVKQV 194
            :.|||:||||.|..|....||.|..|:|:.||:||:|||||..|:|||:..|:||:.|.:.:.:.
  Fly   131 LCVNPNLFSLGIPNCMANLNWLPDALNRSMQGITAVLLSLKLNPVIRYRAGSQAAQLLAKLIYEQ 195

Mouse   195 ISKEYELFEFRRT---EVPPLLLILDRCDDAITPLLNQWTYQAMVHELLGINNNRIDLSRVPGIS 256
            |:||..||:||..   ..|||||:|||.||.:||||:||||||||||||.|.|||:|||..|.:.
  Fly   196 ITKESSLFDFRSNMDGAAPPLLLVLDRRDDPVTPLLHQWTYQAMVHELLHIKNNRLDLSNCPNVP 260

Mouse   257 KDLREVVLSAENDEFYANNMYLNFAEIGSNIKNLMEDFQKKRPKEQQKLESIADMKAFVENYPQF 321
            ||.:|:|||.:.|:||.||||.|:.||||.||.|||:||:| ..:.:|:|||||||.|:|:||||
  Fly   261 KDFKELVLSGDQDDFYGNNMYANYGEIGSTIKQLMEEFQRK-ANDHKKVESIADMKNFIESYPQF 324

Mouse   322 KKMSGTVSKHVTVVGELSRLVSERNLLEVSEVEQELACQNDHSSALQNVKRLLQNPKVTEFDAVR 386
            |||||||.||:.|:||||.|.::|||.||||:|||:||:.:||:.||.:|:|:.:.:|:..||::
  Fly   325 KKMSGTVQKHLCVIGELSALSNKRNLFEVSELEQEIACKAEHSAQLQRIKKLIADERVSIDDALK 389

Mouse   387 LVMLYALHYERHSSNSLPGLIVDLRSKGVAEKYRKLVSAVVEYGGKRVRGSDLFSP---KDAVAI 448
            ||.||||.||||::....||:..::::|   ....:|.:::||.|..||..|||:.   .|||.:
  Fly   390 LVALYALRYERHANCDTSGLLQIIKTRG---GRAAIVPSLIEYAGTHVRQGDLFNMVRITDAVKL 451

Mouse   449 TKQFLKGLKGVENVYTQHQPFLHETLDHLIKGRLKENLYPYLGPSTL--RDRPQDIIVFIIGGAT 511
            |:..:|||||||||:|||.|.|.|||:.:.|||..:.|:|.:....:  |..||:::||||||||
  Fly   452 TRNLIKGLKGVENVFTQHTPLLKETLEDVFKGRELDPLFPAINSELVPFRRPPQEVVVFIIGGAT 516

Mouse   512 YEEALTVYNLNRTTPGVRIVLGGTTIHNTKSFLEEVLA--SGL---HSRS 556
            |||||.|:.||..  |.:::||||||||::||::||:|  ||:   |::|
  Fly   517 YEEALAVHQLNNA--GYKVILGGTTIHNSQSFIQEVVAATSGIQFKHTKS 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps45	NP_038869.1	Sec1	23..539	CDD:279352	286/524 (55%)
Vps45	NP_649909.1	Sec1	23..543	CDD:279352	288/528 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847431
Domainoid	1	1.000	578	1.000	Domainoid score	I217
eggNOG	1	0.900	-	-		E1_COG5158
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5250
Inparanoid	1	1.050	608	1.000	Inparanoid score	I924
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53693
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005111
OrthoInspector	1	1.000	-	-		oto92049
orthoMCL	1	0.900	-	-		OOG6_101522
Panther	1	1.100	-	-	LDO	PTHR11679
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1689
SonicParanoid	1	1.000	-	-		X3630
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790