DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Slc32a1 and VGAT

DIOPT Version :9

Sequence 1:	NP_033534.2	Gene:	Slc32a1 / 22348	MGIID:	1194488	Length:	525	Species:	Mus musculus
Sequence 2:	NP_610938.1	Gene:	VGAT / 36574	FlyBaseID:	FBgn0033911	Length:	549	Species:	Drosophila melanogaster

Alignment Length:	470	Identity:	219/470 - (46%)
Similarity:	302/470 - (64%)	Gaps:	24/470 - (5%)

- Green bases have known domain annotations that are detailed below.

Mouse    65 SEGEPCGDEGAE--------APVEGDIHYQ-----RGGAPLPPSGSKDQAVGAGGEFGGHDKPKI 116
            ::||..||...|        :..|.|..||     |.|: :...||.....|.||  ||   .||
  Fly    83 NDGEGGGDGDGEYRNEYQSTSFNEYDGRYQQTDGFRQGS-IASEGSSFVCEGEGG--GG---CKI 141

Mouse   117 TAWEAGWNVTNAIQGMFVLGLPYAILHGGYLGLFLIIFAAVVCCYTGKILIACLYE-ENEDGEVV 180
            ..::|.|||||||||||::.||:|:|||||..:..::..|.:||||||:|:.|||| :...|::|
  Fly   142 DEFQAAWNVTNAIQGMFIVSLPFAVLHGGYWAIVAMVGIAHICCYTGKVLVQCLYEPDPATGQMV 206

Mouse   181 RVRDSYVAIANACCAPRFPTLGGRVVNVAQIIELVMTCILYVVVSGNLMYNSFPGLPVSQKSWSI 245
            ||||||||||..|..|:   ||.|.|::||:|||:|||||||||.|:|:..::|......:||.:
  Fly   207 RVRDSYVAIAKVCFGPK---LGARAVSIAQLIELLMTCILYVVVCGDLLAGTYPQGSFDSRSWML 268

Mouse   246 IATAVLLPCAFLKNLKAVSKFSLLCTLAHFVINILVIAYCLSRARDWAWEKVKFYIDVKKFPISI 310
            .....|||..|||:||.||..|..||::|.|||.:::.|||.:..||.|.||:|.||::.||||:
  Fly   269 FVGIFLLPMGFLKSLKMVSTLSFWCTMSHIVINAVILGYCLLQIGDWGWSKVRFSIDMENFPISL 333

Mouse   311 GIIVFSYTSQIFLPSLEGNMQQPSEFHCMMNWTHIAACVLKGLFALVAYLTWADETKEVITDNLP 375
            |:||||||||||||:|||||...|:|:.|::|:||||.|.|..|..:.:||:.::|::|||:||.
  Fly   334 GVIVFSYTSQIFLPTLEGNMIDRSKFNWMLDWSHIAAAVFKAGFGYICFLTFQNDTQQVITNNLH 398

Mouse   376 G-SIRAVVNLFLVAKALLSYPLPFFAAVEVLEKSLFQEGSRAFFPACYGGDGRLKSWGLTLRCAL 439
            . ..:.:||.|||.|||||||||::||.|:||::.|:...:..||..:..||.||.|||..|..:
  Fly   399 SQGFKGMVNFFLVIKALLSYPLPYYAACELLERNFFRGPPKTKFPTIWNLDGELKVWGLGFRVGV 463

Mouse   440 VVFTLLMAIYVPHFALLMGLTGSLTGAGLCFLLPSLFHLRLLWRKLLWHQVFFDVAIFVIGGICS 504
            :|.|:||||::|||::|||..||.||..|.|:.|..||:::....|...::..|..|..:|.:..
  Fly   464 IVSTILMAIFIPHFSILMGFIGSFTGTMLSFIWPCYFHIKIKGHLLDQKEIAKDYLIIGLGVLFG 528

Mouse   505 VSGFVHSLEGLIEAY 519
            |.|...|...||.|:
  Fly   529 VIGIYDSGNALINAF 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc32a1	NP_033534.2	Aa_trans	115..512	CDD:279788	197/398 (49%)
VGAT	NP_610938.1	SLC5-6-like_sbd	144..533	CDD:382020	195/391 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848920
Domainoid	1	1.000	402	1.000	Domainoid score	I731
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56451
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1843
Isobase	1	0.950	-	0	Normalized mean entropy	S2954
OMA	1	1.010	-	-		QHG52048
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007337
OrthoInspector	1	1.000	-	-		oto91888
orthoMCL	1	0.900	-	-		OOG6_100570
Panther	1	1.100	-	-	LDO	PTHR48017
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2046
SonicParanoid	1	1.000	-	-		X361
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740