DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vhl and Vhl

DIOPT Version :9

Sequence 1:	NP_033533.1	Gene:	Vhl / 22346	MGIID:	103223	Length:	181	Species:	Mus musculus
Sequence 2:	NP_001260885.1	Gene:	Vhl / 53433	FlyBaseID:	FBgn0041174	Length:	178	Species:	Drosophila melanogaster

Alignment Length:	167	Identity:	40/167 - (23%)
Similarity:	65/167 - (38%)	Gaps:	42/167 - (25%)

- Green bases have known domain annotations that are detailed below.

Mouse    33 NSREPSQ------------VIFCNRSPRVVLPLWLNFDGEPQPYPILPPGTGRRIHSYRGHLWLF 85
            |:|:..|            |:|.|.:.|.:...|:........|..|.|....|::::..|.|||
  Fly     8 NNRDGQQLVGADQGKVEVYVLFANTTYRTLDLYWVCERERENMYLTLKPFEEVRVNTFTTHSWLF 72

Mouse    86 RDAGTHDGLLVNQTELFVP--------------SLNVDGQPIFANITLPVYTLKERCLQVV-RSL 135
            ||..|.:.:.|....:|.|              .::|..:.:   |..|:.:|:|.||.:| |.|
  Fly    73 RDYYTGERMHVRSQRIFQPIRVRVPKSQQSPDQLVDVRSEVL---IHFPMRSLRENCLWLVARWL 134

Mouse   136 VKPENYRRLDI------------VRSLYEDLEDYPSV 160
            ::..|..|..|            :.||...:|.|..|
  Fly   135 IRTSNAPRRIIHGYHIPSTLKQQLLSLLTCIESYSRV 171

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vhl	NP_033533.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		VHL	27..171	CDD:280091	40/167 (24%)
		Interaction with Elongin BC complex. /evidence=ECO:0000250	123..132		4/8 (50%)
Vhl	NP_001260885.1	pVHL	21..162	CDD:176472	34/142 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850097
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4710
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005700
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_107013
Panther	1	1.100	-	-	LDO	PTHR15160
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9301
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.730