DRSC/TRiP Functional Genomics Resources

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Protein Alignment Vdr and Hr96

DIOPT Version :9

Sequence 1:NP_033530.2 Gene:Vdr / 22337 MGIID:103076 Length:422 Species:Mus musculus
Sequence 2:NP_524493.1 Gene:Hr96 / 42993 FlyBaseID:FBgn0015240 Length:723 Species:Drosophila melanogaster


Alignment Length:740 Identity:142/740 - (19%)
Similarity:221/740 - (29%) Gaps:368/740 - (49%)


- Green bases have known domain annotations that are detailed below.


Mouse    21 PRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKRCV 85
            |:.|.||||:|.|::|||:|||.||.||||:...|..||||||.:|.||...||.||.|||::|:
  Fly     4 PKNCAVCGDKALGYNFNAVTCESCKAFFRRNALAKKQFTCPFNQNCDITVVTRRFCQKCRLRKCL 68

Mouse    86 DIGMMKEFILTDEEVQRKREMI------------------------------------------- 107
            ||||..|.|:::|:...||..|                                           
  Fly    69 DIGMKSENIMSEEDKLIKRRKIETNRAKRRLMENGTDACDADGGEERDHKAPADSSSSNLDHYSG 133

Mouse   108 --------------------------------------------------------MKRKEEEAL 116
                                                                    :.|.::||:
  Fly   134 SQDSQSCGSADSGANGCSGRQASSPGTQVNPLQMTAEKIVDQIVSDPDRASQAINRLMRTQKEAI 198

Mouse   117 ----------KDSLR--------------------------------------------PKLSEE 127
                      ||:||                                            .|:.:.
  Fly   199 SVMEKVISSQKDALRLVSHLIDYPGDALKIISKFMNSPFNALTVFTKFMSSPTDGVEIISKIVDS 263

Mouse   128 QQHIIAILLDAHHKTYD-----------PTYA--------------------------------- 148
            ...::..:.:..|...|           |..|                                 
  Fly   264 PADVVEFMQNLMHSPEDAIDIMNKFMNTPAEALRILNRILSGGGANAAQQTADRKPLLDKEPAVK 328

Mouse   149 -----------------------------DFRDFRPPIRADVSTGSYSPRPTLSFSGDSSSNSDL 184
                                         |.:...|.:....||.|..|.|.::.|.|....:.:
  Fly   329 PAAPAERADTVIQSMLGNSPPISPHDAAVDLQYHSPGVGEQPSTSSSHPLPYIANSPDFDLKTFM 393

Mouse   185 YT-----PSLD--------------------------------MMEPASFSTM------------ 200
            .|     ||||                                :.|..|:.|.            
  Fly   394 QTNYNDEPSLDSDFSINSIESVLSEVIRIEYQAFNSIQQAASRVKEEMSYGTQSTYGGCNSAANN 458

Mouse   201 -------------------DLNE-------------EGSDDPSVTLDLSPLSM------------ 221
                               :|||             |...|| |..|||.|.|            
  Fly   459 SQPHLQQPICAPSTQQLDRELNEAEQMKLRELRLASEALYDP-VDEDLSALMMGDDRIKPDDTRH 522

Mouse   222 ---LPHLADLVSYSIQKVIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTLDDMSWDC 283
               |..|.:|.:.:|:::|..||.|..|||:..:||:.|||....|::::||...:..|..:|  
  Fly   523 NPKLLQLINLTAVAIKRLIKMAKKITAFRDMCQEDQVALLKGGCTEMMIMRSVMIYDDDRAAW-- 585

Mouse   284 GSQDYKYDITDVSRAGHTLE----LIEPLIKFQVGLKKLNLHEE---------------EHVLLM 329
                         :..||.|    :...|:||..|    |::||               |:::|:
  Fly   586 -------------KVPHTKENMGNIRTDLLKFAEG----NIYEEHQKFITTFDEKWRMDENIILI 633

Mouse   330 --AICIVSPDRPGVQDAKLVEAIQDRLSNTLQTYIRCRHPPPGSHQLYAKMIQKLADLRSLNEEH 392
              ||.:.:..|..|....::...|:.....|:.|:...:....:...:.|:|||::|:..||:..
  Fly   634 MCAIVLFTSARSRVIHKDVIRLEQNSYYYLLRRYLESVYSGCEARNAFIKLIQKISDVERLNKFI 698

Mouse   393 SKQYRSLSFQPENSMKLTPLVLEVF 417
            ...|.::     |..::.||:.|:|
  Fly   699 INVYLNV-----NPSQVEPLLREIF 718

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
VdrNP_033530.2 NR_DBD_VDR 16..122 CDD:143513 55/253 (22%)
Hinge 97..126 12/181 (7%)
NR_LBD_VDR 124..421 CDD:132731 86/484 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 161..185 7/23 (30%)
Vitamin D3 binding. /evidence=ECO:0000250 222..232 3/9 (33%)
Interaction with coactivator LXXLL motif. /evidence=ECO:0000250 241..259 8/17 (47%)
Vitamin D3 binding. /evidence=ECO:0000250 266..273 2/6 (33%)
9aaTAD. /evidence=ECO:0000250|UniProtKB:P11473 411..419 4/7 (57%)
Hr96NP_524493.1 NR_DBD_CAR 5..98 CDD:143524 47/92 (51%)
NR_LBD 462..>573 CDD:299703 29/111 (26%)
NR_LBD_F1 523..702 CDD:132727 47/197 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167847959
Domainoid 1 1.000 99 1.000 Domainoid score I7064
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 171 1.000 Inparanoid score I4095
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D153746at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24082
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R6384
SonicParanoid 1 1.000 - - X988
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
99.030

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