Protein Alignment Vdr and EcR

DIOPT Version :9

• Sequence 1: NP_033530.2
• Gene: Vdr / 22337
• MGIID: 103076
• Length: 422
• Species: Mus musculus
• Sequence 2: NP_001163061.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Alignment Length: 450
• Identity: 137/450 - (30%)
• Similarity: 211/450 - (46%)
• Gaps: 77/450 - (17%)

Mouse     2 EAMAASTSLPDPGDFDRNVPRI----CGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPF 62
            |:..|..|...|      .||:    |.||||||:|:|:||:||||||||||||:.:.|::.|.|
  Fly   244 ESCDAKKSKKGP------APRVQEELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAVYCCKF 302

Mouse    63 NGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMIMKRKEEEALKDSLRPKLSEE 127
            ...|.:....||.||.||||:|:.:||..|.::.:      .:..|||:|::|.|:..:...|..
  Fly   303 GRACEMDMYMRRKCQECRLKKCLAVGMRPECVVPE------NQCAMKRREKKAQKEKDKMTTSPS 361

Mouse   128 QQH--IIAILLDAHHKTYDPTYADFRDFRPPIRADVSTGSYSPRPTLSFSGDSSSNSDLYTPSLD 190
            .||  ..::..............|.....||..|.:..     .|....:...:.|    .|||.
  Fly   362 SQHGGNGSLASGGGQDFVKKEILDLMTCEPPQHATIPL-----LPDEILAKCQARN----IPSLT 417

Mouse   191 MMEPASFSTMDLNEEGSDDPSVTLDLSPLSMLP------------HLADLVSYSIQKVIGFAKMI 243
            ..:.|....:...::|.:.||.. ||..:...|            |:.::...::|.::.|||.:
  Fly   418 YNQLAVIYKLIWYQDGYEQPSEE-DLRRIMSQPDENESQTDVSFRHITEITILTVQLIVEFAKGL 481

Mouse   244 PGFRDLTSDDQIVLLKSSAIEVIMLR---------------SNQSFTLDDMSWDCGSQDYKYDIT 293
            |.|..:..:|||.|||:.:.||:|||               :|:|:|.|         .||
  Fly   482 PAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSSDSIFFANNRSYTRD---------SYK---- 533

Mouse   294 DVSRAGHTLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAKLVEAIQDRLSNTL 358
               .|| ..:.||.|:.|...:..:.:...|:.||.||.|.| ||||::.|:||||||....:||
  Fly   534 ---MAG-MADNIEDLLHFCRQMFSMKVDNVEYALLTAIVIFS-DRPGLEKAQLVEAIQSYYIDTL 593

Mouse   359 QTYIRCRHPPPG-SHQLYAKMIQKLADLRSLNEEHSKQYRSLSFQPENSMKLTPLVLEVF 417
            :.||..||.... |...|||::..|.:||:|..::::...||..:   :.||...:.|::
  Fly   594 RIYILNRHCGDSMSLVFYAKLLSILTELRTLGNQNAEMCFSLKLK---NRKLPKFLEEIW 650

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vdr	NP_033530.2	NR_DBD_VDR	16..122	CDD:143513	47/109 (43%)
		Hinge	97..126		6/28 (21%)
		NR_LBD_VDR	124..421	CDD:132731	86/323 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	161..185		2/23 (9%)
		Vitamin D3 binding. /evidence=ECO:0000250	222..232		2/21 (10%)
		Interaction with coactivator LXXLL motif. /evidence=ECO:0000250	241..259		7/17 (41%)
		Vitamin D3 binding. /evidence=ECO:0000250	266..273		4/21 (19%)
		9aaTAD. /evidence=ECO:0000250|UniProtKB:P11473	411..419		1/6 (17%)
EcR	NP_001163061.1	NR_DBD_EcR	261..351	CDD:143535	44/95 (46%)
		NR_LBD_EcR	420..652	CDD:132736	74/252 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847960
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940