Protein Alignment Vcl and alpha-Cat

DIOPT Version :9

• Sequence 1: XP_006518985.1
• Gene: Vcl / 22330
• MGIID: 98927
• Length: 1134
• Species: Mus musculus
• Sequence 2: NP_524219.1
• Gene: alpha-Cat / 40517
• FlyBaseID: FBgn0010215
• Length: 917
• Species: Drosophila melanogaster
• Alignment Length: 1151
• Identity: 238/1151 - (20%)
• Similarity: 425/1151 - (36%)
• Gaps: 330/1151 - (28%)

Mouse     6 TRTIESILEPVAQQISHLVIMHEEG---EVDGKAIPDLTAPVAAVQAAVSNLVRVGKETVQTTED 67
            |.::|..|||:..|::.||  :.:|   :..||: ...:|.||||:.|..|.::.|::......|
  Fly    29 TMSVEKTLEPLVLQVTTLV--NTKGPSKKKKGKS-KRASALVAAVEKATENFIQKGEQIAYENPD 90

Mouse    68 QILKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSGTSDLLLTFDEAEVR 132
              :.::|..|..:|:.....:..||:....||.|...|..::..:|.:||..:.||:..|..:|.
  Fly    91 --ITQEMLTAVDEVKKTGDAMSIAAREFSEDPCSSLKRGNMVRAARNLLSAVTRLLILADMVDVH 153

Mouse   133 KIIRVCKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQELTHQEHRVMLVNSMNT 197
            .:::....:.:.|...:...:.::|:...:..|....::.|...:|||||...:.|..|..:...
  Fly   154 LLLKSLHIVEDDLNKLKNASSQDELMDNMRQFGRNAGELIKQAAKRQQELKDPQLRDDLAAARAM 218

Mouse   198 VKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAEINEIIRVLQLTSWDEDAWASKD 262
            :|:...:|::|.|::|     ::..::.|..||:|
  Fly   219 LKKHSTMLLTASKVYV-----RHPELDLAKVNRDF------------------------------ 248

Mouse   263 TEAMKRALASIDSKLNQAKGWLRDPNASPGDAGEQAIRQILDEAGKVGELCAGKERREILGTCKM 327
                                               .::|:.|....:.::..||
  Fly   249 -----------------------------------ILKQVCDAVNTISDVAQGK----------- 267

Mouse   328 LGQMTDQVADLRARGQGASPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQ 392
                :.|..|:.: |.|....|:   ....:|:            .::.||.|::...:.:
  Fly   268 ----SSQPTDIYS-GAGELAAAL---DDFDEGI------------VMDPMTYSEKRSRQLL---- 308

Mouse   393 NWLADPNGGPEGEEQIRGALAEARKIAEL-CDDPKERDDILRSLGEIAALTSKLGDLRRQGKGDS 456
                        ||::...::.|..:|:. |...:.|:   |.:.|..|:...|.||
  Fly   309 ------------EERLESIISAAALMADADCTRDERRE---RIVAECNAVRQALQDL-------- 350

Mouse   457 PEARALAKQVATALQNLQTKTNRAVANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRG 521
                     ::..:.|:..|.|                           :|     |:.:|
  Fly   351 ---------LSEYMSNMSQKDN---------------------------SP-----GLSRA---- 370

Mouse   522 LVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKAQ 586
                                      :||:..:                         .:||:.|
  Fly   371 --------------------------IDQMCRK-------------------------TRDLRRQ 384

Mouse   587 MQEAMTQEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGRLGATAEKAAAVG 651
            :::|:...|||.|.:||||:..|..||.:     ..|:...|::..|..|:.:|...|....::.
  Fly   385 LRKAVVDHVSDSFLETTTPLLDLIEAAKS-----GNEKKVREKSEIFTKHAEKLVEVANLVCSMS 444

Mouse   652 TANKSTVEGIQASVKTARELTPQVISAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGLVDEA 716
            . |:..|:.::.:......|.||||:||.||...|.::.|.|:..|.:..|...|..:|..||:.
  Fly   445 N-NEDGVKMVRYAAAQIESLCPQVINAASILTVRPNSKVAQENMTTYRQAWEVQVRILTEAVDDI 508

Mouse   717 IDTKSLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILLVAKREVENSE----DP 777
            ......|..||..|.:|::||.:|:.....:.|.|.|.:|..|::|:..|.:.|::|.|    ..
  Fly   509 TTIDDFLAVSENHILEDVNKCVMALQVGDARDLRATAGAIQGRSSRVCNVVEAEMDNYEPCIYTK 573

Mouse   778 KFREAVKAASDELSKTISPMVMDAKAVAGNISDPGL-QKSFLDSGYRILGAVAKVREAFQPQEPD 841
            :..||||...|::.......|..|.....|.|:..: :..|:|:...:...|.::|.|
  Fly   574 RVLEAVKVLRDQVMMKFDQRVGAAVGALSNNSNKDVDENDFIDASRLVYDGVREIRRA------- 631

Mouse   842 FPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAGEVINQPMMMAARQLH 906
                   :...|.:::|                     :.|.||          :|:    ..|.
  Fly   632 -------VLMNRSSEDL---------------------DTDTEF----------EPV----EDLT 654

Mouse   907 DEARKWSSKPGIPAAQVGIGVVAEANAADAVGFPFPSDMEDDYEPELLLMPSNQPVNQPILAAAQ 971
            .|.|..||                |:..|.....:| |:.........:....:...|.|....:
  Fly   655 LETRSRSS----------------AHTGDQTVDEYP-DISGICTAREAMRKMTEEDKQKIAQQVE 702

Mouse   972 SLHR-------EATKWSSKGNDIIAAAKRMALLMAEMSRLVRGGSGTKRAL--IQCAKDIAKASD 1027
            ...|       |..||...|||||..||.|.::|.||:...||....|..:  |..||.|::|..
  Fly   703 LFRREKLTFDSEVAKWDDTGNDIIFLAKHMCMIMMEMTDFTRGRGPLKTTMDVINAAKKISEAGT 767

Mouse  1028 EVTRLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDE----ESEQAT 1088
            ::.:|.:|:|:||.:...:.:||...:||.....|::|.|.|||.:   .|||.|    ..:.||
  Fly   768 KLDKLTREIAEQCPESSTKKDLLAYLQRIALYCHQIQITSKVKADV---QNISGELIVSGLDSAT 829

Mouse  1089 EMLVHNAQNLMQSVKETVREAEAASIKIR---TDAGFTLRWVRKTP 1131
            . |:..|:|||.:|..||:.:..||.|..   |.:...:.|..|.|
  Fly   830 S-LIQAAKNLMNAVVLTVKYSYVASTKYTRQGTVSSPIVVWKMKAP 874

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vcl	XP_006518985.1	Vinculin	3..1134	CDD:366435	238/1151 (21%)
alpha-Cat	NP_524219.1	Vinculin	87..877	CDD:395830	219/1090 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3681
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810