DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kdm6a and Utx

DIOPT Version :9

Sequence 1:	XP_006527657.1	Gene:	Kdm6a / 22289	MGIID:	1095419	Length:	1476	Species:	Mus musculus
Sequence 2:	NP_609368.3	Gene:	Utx / 34377	FlyBaseID:	FBgn0260749	Length:	1136	Species:	Drosophila melanogaster

Alignment Length:	1494	Identity:	570/1494 - (38%)
Similarity:	738/1494 - (49%)	Gaps:	463/1494 - (30%)

- Green bases have known domain annotations that are detailed below.

Mouse    43 LTAEEREALGGLDSRLFGFVRF-HEDGARMKALLGKAVRCYESLILKA---EGKVESD------- 96
            ||.|:...:..||||.:||:.. :...|.::.|:.:.:...::.|...   |.|..||
  Fly     4 LTFEDDCLIRELDSRYYGFLDLSNSKNAELRNLVQQTITNLQNYIANGQVHESKNSSDNKNAIQK 68

Mouse    97 -----------------------------------------------FFCQLGHFNLLLEDYPKA 114
                                                           ..|:|||.:|||.:|.:|
  Fly    69 FEPSTQAGEHMENTSSRNNDDTKPFEQDAKEKVSIIEEKHQDEHYVNALCKLGHLHLLLGEYSEA 133

Mouse   115 LSAYQRYYSL-QSDYWKNAAFLYGLGLVYFHYNAFQWAIKAFQEVLYVDPSFCRAKEIHLRLGLM 178
            |||||:|... :::||.|.||:||:|:.||....|:||||:|||:||:.|:|..|.|:|||||||
  Fly   134 LSAYQKYLRFRENNYWTNHAFIYGIGVAYFKLRCFKWAIKSFQELLYLSPNFTCANEVHLRLGLM 198

Mouse   179 FKVNTDYESSLKHFQLALVDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLSAQV 243
            .|...::..:|||.||||:...|.|.|..:::|.||||||.|.|:.:||:.||.||..:|:|.::
  Fly   199 LKHCGEFHIALKHLQLALLYTYPSTFSELQVKFQIAHLYEVQNKHKAAKDGYEFLLNEKNISLEL 263

Mouse   244 KATILQQLGWMHHTVDLLGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFIS 308
            ||.:.:|||||:|.|:.||:|..:|:.|:.:||||:||||.||||.|.|||||:.|.||.|||::
  Fly   264 KADVYRQLGWMYHCVECLGEKKEREANALNFLQKSIEADPKSGQSLYLLGRCYAGINKVHDAFLA 328

Mouse   309 YRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDA 373
            ||.|::|||.:|||||||||||||||||.|||||||||||||..|.|||.:||.|||||.|.:||
  Fly   329 YRNSVEKSEGNADTWCSIGVLYQQQNQPTDALQAYICAVQLDKDHKAAWTNLGILYESCGQLRDA 393

Mouse   374 IKCYLNATRSKNCSNTS-------------------GLAARIKYLQAQLCNLPQGSLQNKTKLLP 419
            ..||||||:..:...:|                   ||:.||.:|:.||...|..|:.:|.:.|.
  Fly   394 YACYLNATKQISFQKSSLIRKKQAIRMKKDTIGLSKGLSQRITFLEGQLSQAPLPSITSKRRQLC 458

Mouse   420 SIEEAWSLPIPAELTSRQGAMNTAQQACKPHHPNTEPVLGLSQTPISQQSLPLHMIPPSQVDDLS 484
            ||||||:|||..|:.|||
  Fly   459 SIEEAWNLPISLEMNSRQ----------------------------------------------- 476

Mouse   485 SPAKRKRTSSPTKNTSDNWSGGNAPPPVEQQTHSWCLTPQKLQHLEQLRANRNNLNPAQKLMLEQ 549
                                         |||                         ||.|
  Fly   477 -----------------------------QQT-------------------------AQML---- 483

Mouse   550 LESQFVLMQQHQMRQTGVAQVRPTGILNGPTVDSSLPTNSVSGQQPQLPLTRMPSVSQPGVHTAC 614

  Fly   484 ----------------------------------------------------------------- 483

Mouse   615 PRQTLANGPFSAGHVPCSTSRTLGSTDTVLIGNNHVTGSGSNGNVPYLQRNAPTLPHNRTNLTSS 679
            |||.....|                                      :|...|..||
  Fly   484 PRQVTKQSP--------------------------------------VQGPPPPYPH-------- 502

Mouse   680 TEEPWKNQLSNSTQGLHKGPSSHLAGPNGERPLSSTGPSQHLQAAGSGIQ--NQNGHPTLPSNSV 742
                  :|||.|                   |:    ||:.::..|:..|  .||...|...|.:
  Fly   503 ------SQLSQS-------------------PI----PSKRIKEDGTSQQEVTQNNSQTSAQNLI 538

Mouse   743 TQGAALNHLSSHTATSGGQQGITLTKESKPSGNTLTVPETSRQTGETPNSTASVEGLPNHVHQVM 807
            ....:||           |:......||..|.....:......:.:......|::     :.::.
  Fly   539 NISESLN-----------QRNFNAMPESNKSSEQSVLDTFDDISNDIYKQNESIK-----LERLS 587

Mouse   808 ADAVCSPSHGDSKSPGLLSSDNPQLSALLMGKANNNVGPGTCDKVNNIHPTVHTKTDNSVASSPS 872
            .||:   |:.:......:..||..:|
  Fly   588 QDAL---SNNEDSRHDFIGGDNADIS--------------------------------------- 610

Mouse   873 SAISTATPSPKSTEQTTTNSVTSLNSPHSGLHTINGEGMEESQSPIKTDLLLVSHRPSPQIIPSM 937
                            ||..:.                |:..|..:...||.:...|
  Fly   611 ----------------TTFKIQ----------------MDSKQLMVAVKLLPIDEPP-------- 635

Mouse   938 SVSIYPSSAEVLKACRNLGKNGLSNSSILLDKCPPPRPPSSPYPPLPKDKLNPPTPSIYLENKRD 1002
                                   .:.:||....|||.||..|...|.:|:|.|||||::||||:.
  Fly   636 -----------------------VHCTILQVNAPPPSPPDCPPQKLTRDQLLPPTPSVHLENKKH 677

Mouse  1003 AFFPPLHQFCTNPNNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWDPT 1067
            ||.|.|.:||.  .:|:.|:|||||.|||||||||||||||||.:|.||||||:.|..|||||.:
  Fly   678 AFSPQLQEFCL--KHPIAVVRGLAGVLKLDLGLFSTKTLVEANPDHSVEVRTQVHQSPDENWDTS 740

Mouse  1068 GTKKIWHCESNRSHTTIAKYAQYQASSFQESLR-----EENEK---RSHHKDHSDS-ESTSSDN- 1122
            ..|::|.|.|:||||||||||||||||||:||:     :|::|   .|.....||| :|.|:.|
  Fly   741 QGKRVWACISHRSHTTIAKYAQYQASSFQDSLKLILPQDESDKGFPGSQAMSDSDSKDSVSNSNI 805

Mouse  1123 --SGKRRKGPFKTIKFGTNIDLSDDKKWKLQLHELTKLPAFVRVVSAGNLLSHVGHTILGMNTVQ 1185
              ..|:.|...|.::||||:||||:||||.||.||.|||||.||:||.|:||||||.||||||||
  Fly   806 VLKRKKHKINSKMLRFGTNVDLSDEKKWKPQLTELQKLPAFARVISAANMLSHVGHVILGMNTVQ 870

Mouse  1186 LYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEGYWGVLNDFCEKNNLNFLMGSWWPNLE 1250
            |||||||||||||||||||||:||||||||||||.||:.|||.:::.|||||:::|.|||||.||
  Fly   871 LYMKVPGSRTPGHQENNNFCSININIGPGDCEWFAVPDAYWGGVHNLCEKNNISYLHGSWWPVLE 935

Mouse  1251 DLYEANVPVYRFIQRPGDLVWINAGTVHWVQAIGWCNNIAWNVGPLTACQYKLAVERYEWNKLQN 1315
            |||:.|:|||||||:||||||:|||.|||||:||||||||||||||||.||.||:|||||||:|.
  Fly   936 DLYKENIPVYRFIQKPGDLVWVNAGCVHWVQSIGWCNNIAWNVGPLTARQYSLAIERYEWNKVQA 1000

Mouse  1316 VKSIVPMVHLSWNMARNIKVSDPKLFEMIKYCLLRTLKQCQTLREALIAAGKEIIWHGRTKEEPA 1380
            .||||||||||||:||||||||.||||:||.|||:|||....::|.:.:.|.||.::||.|.|.:
  Fly  1001 FKSIVPMVHLSWNLARNIKVSDTKLFELIKMCLLQTLKNVLHIQEYVKSKGVEIRFNGRGKNEAS 1065

Mouse  1381 HYCSICEVEVFDLLFVTNESNSRKTYIVHCQDCARKTSGNLENFVVLEQYKMEDLMQVYDQFTL 1444
            |||..||||||::||:..:   .|.::|||..||.|.|.:|:..|.||:|::.:|.:|||.|||
  Fly  1066 HYCGQCEVEVFNVLFIKEQ---EKRHVVHCLSCALKLSPSLQGIVCLEEYRLSELQRVYDSFTL 1126

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm6a	XP_006527657.1	TPR repeat	95..123	CDD:276809	17/81 (21%)
		TPR	108..401	CDD:223533	168/312 (54%)
		TPR repeat	131..161	CDD:276809	17/29 (59%)
		TPR repeat	166..196	CDD:276809	15/29 (52%)
		TPR repeat	207..235	CDD:276809	14/27 (52%)
		TPR repeat	287..314	CDD:276809	17/26 (65%)
		TPR repeat	319..349	CDD:276809	27/29 (93%)
		TPR repeat	354..380	CDD:276809	16/25 (64%)
		JmjC	1151..1215	CDD:214721	55/63 (87%)
		JmjC	1185..1293	CDD:334913	86/107 (80%)
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809	19/33 (58%)
		TPR_11	156..216	CDD:290150	32/59 (54%)
		TPR repeat	186..216	CDD:276809	15/29 (52%)
		TPR repeat	228..255	CDD:276809	14/26 (54%)
		TPR_11	264..337	CDD:290150	42/72 (58%)
		TPR repeat	265..300	CDD:276809	17/34 (50%)
		TPR repeat	307..334	CDD:276809	17/26 (65%)
		TPR_11	339..402	CDD:290150	49/62 (79%)
		TPR repeat	339..369	CDD:276809	27/29 (93%)
		TPR_1	340..373	CDD:278916	30/32 (94%)
		TPR repeat	374..402	CDD:276809	18/27 (67%)
		JmjC	870..978	CDD:202224	86/107 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848340
Domainoid	1	1.000	507	1.000	Domainoid score	I333
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7586
Inparanoid	1	1.050	1043	1.000	Inparanoid score	I264
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49086
OrthoDB	1	1.010	-	-		D141383at33208
OrthoFinder	1	1.000	-	-		FOG0001095
OrthoInspector	1	1.000	-	-		otm44356
orthoMCL	1	0.900	-	-		OOG6_101645
Panther	1	1.100	-	-	LDO	PTHR14017
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R281
SonicParanoid	1	1.000	-	-		X932
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800