Protein Alignment Usp9x and faf

DIOPT Version :9

• Sequence 1: XP_006527649.1
• Gene: Usp9x / 22284
• MGIID: 894681
• Length: 2575
• Species: Mus musculus
• Sequence 2: NP_524612.2
• Gene: faf / 43749
• FlyBaseID: FBgn0005632
• Length: 2778
• Species: Drosophila melanogaster
• Alignment Length: 2662
• Identity: 1258/2662 - (47%)
• Similarity: 1694/2662 - (63%)
• Gaps: 247/2662 - (9%)

Mouse     2 TATTRGSP---VGGNDNQGQAPDGQSQPPLQQNQTSSPDSSNENSPATPPDEQGQGD-------- 55
            |.||..||   .|.....|......:...|....:.|.|.:.:..|||  |.|...|
  Fly    27 TTTTTTSPAQSAGSGSGIGTGTGTVANSSLPGGGSGSLDGNQDQQPAT--DSQSSDDVAASLSAN 89

Mouse    56 --------APPQIEDEEPAFPHTDLAKLDDMINRPRWVVPVLPKGELEVLLEAAIDLSKKGLDVK 112
                    .||  |....:||.|.|..|...|:.|||||||||:.||||||.|||:|::.|:|..
  Fly    90 SVDSTITIVPP--EKLISSFPTTKLRSLTQKISNPRWVVPVLPEQELEVLLNAAIELTQAGVDHD 152

Mouse   113 SEACQRFFRDGLTISFTKILTDEAVSGWKFEIHRCIINNTHRLVELCVAKLAQDWFPLLELLAMA 177
            .|.|..|:|:||:.||.||||||||:.||..||.||:.:..:|:.|....:.:|...||:|||:.
  Fly   153 CEPCVEFYRNGLSTSFAKILTDEAVNSWKNNIHHCILVSCGKLLHLIAIHMQRDNPYLLDLLAIV 217

Mouse   178 LNPHCKFHIYN-GTRP-CESVSSSV--QLPEDELFAR-SPDPRSPKGWLVDLLNKFGTLNGFQIL 237
            .:|..||:.:| |.:| |.:....:  ||..::::|| .|:|::.:||||||:|:||.|.||..|
  Fly   218 FDPENKFNTFNAGRQPECFAAPDYIWGQLDSNKMYARPPPEPKNARGWLVDLINRFGQLGGFDNL 282

Mouse   238 HDRFING----------------------------SALNVQIIAALIKPFGQCYEFLTLHTVKKY 274
            .:||..|                            :.|.:.:|.:|::|||||||.|...|:.||
  Fly   283 LERFNIGLELLKRNQNKCTGKNISVEGRVENGAQDNRLTLALIHSLLRPFGQCYELLMPATIAKY 347

Mouse   275 FLPIIEMVPQFLENLTDEELKKEAKNEAKNDALSMIIKSLKNLASRVPGQEETVKNLEIFRLKMI 339
            |:|...:|...|::.||||||:|.|.|.:||.::.|:||.:.||||:.||||.:::||:||||||
  Fly   348 FMPTWNVVLDLLDSFTDEELKREVKPEGRNDYINGIVKSARLLASRLTGQEELIRDLEMFRLKMI 412

Mouse   340 LRLLQISSFNGKMNALNEVNKVISSVSYYTHR-----HGSSEDE-EWLTAERMAEWIQQNNILSI 398
            |||||:||||||||||||:|||:|||:|::||     |...||| :||||:|||:||:.:::|.:
  Fly   413 LRLLQVSSFNGKMNALNEINKVLSSVAYFSHRSQPLPHCMPEDEMDWLTADRMAQWIKSSDVLGV 477

Mouse   399 VLRDSLHQPQYVEKLEKILRFVIKEKALTLQDLDNIWAAQAGKHEAIVKNVHDLLAKLAWDFSPE 463
            ||:|||||||||||||||:||:|||:||||.|||.:|.||||||||||||||||||||||||:||
  Fly   478 VLKDSLHQPQYVEKLEKIIRFLIKEQALTLDDLDAVWRAQAGKHEAIVKNVHDLLAKLAWDFTPE 542

Mouse   464 QLDHLFDCFKASWTNASKKQREKLLELIRRLAEDDKDGVMAHKVLNLLWNLAHSDDVPVDIMDLA 528
            ||||||:.|:||.|.|:|:|||:|||||||||||||:||||.|||.|.|.||||.:||.:::|.|
  Fly   543 QLDHLFEAFQASMTTANKRQRERLLELIRRLAEDDKNGVMAQKVLKLFWTLAHSQEVPPEVLDQA 607

Mouse   529 LSAHIKILDYSCSQDRDTQKIQWIDRFIEELRTNDKWVIPALKQIREICSLFGEAPQNLSSSRFS 593
            |.||:|||||||||:||.||..|:|:.::||::.|.||:|||:.||:||.|:        .:..:
  Fly   608 LGAHVKILDYSCSQERDAQKTIWLDKCVDELKSGDGWVLPALRLIRDICCLY--------DTTTN 664

Mouse   594 QSQRSPHVFYRHDLINQLQHNHALVTLVAENLATYMESMRMYGRDNEDYDPQTVRLGSRYSHVQE 658
            .:||:.....|..:|.:||::::||.||..:|..|||.:|....|:...|...:.:..|:.|..:
  Fly   665 HAQRTQTSTNRQQVIERLQNDYSLVILVTNSLTAYMEKVRQMVTDSPGLDATRILIDGRFPHHVQ 729

Mouse   659 VQERLNFLRFLLKDGQLWLCAPQAKQIWKCLAENAVYLCDREACFKWYSKLMGDEPDLDPDINKD 723
            :.|||.||:||||||||||||.||||||.|||.|||:..|||.||:|:.||||:||||||.||||
  Fly   730 IAERLEFLKFLLKDGQLWLCADQAKQIWHCLAVNAVFPADREECFRWFGKLMGEEPDLDPGINKD 794

Mouse   724 FFESNVLQLDPSLLTENGMKCFERFFKAVNCREGKLVAKRRAYMMDDLELIGLDYLWRVVIQSND 788
            |||:|:|||||.||||:|:|||||||||||.:|.||.|..|.||:|:.:|||.||||||:....:
  Fly   795 FFENNILQLDPHLLTESGIKCFERFFKAVNSKEDKLKAIHRGYMLDNEDLIGKDYLWRVITTGGE 859

Mouse   789 DIACRAIDLLKEIYTNLGPRLQVNQVVIHEDFIQSCFDRLKASYDTLCVL--------------- 838
            :||.:|||||||:.|.||||||.|....||.||..|..||:..|..:.:|
  Fly   860 EIASKAIDLLKEVSTALGPRLQENIAEFHEMFIGECCSRLRTHYGNIVILGKTQLQEELDAPDQS 924

Mouse   839 ----DGDKDSINCARQEAVRMVRVLTVLREYINECDSDYHEERTILPMSRAFRGKHLSFIVRFPN 899
                |..||| .....||.:|.|:|.||:||:.|||..:..:|..||:||..|||:....:||.|
  Fly   925 DNTNDESKDS-KMRFIEAEKMCRILKVLQEYVKECDRSFSGDRVHLPLSRVTRGKNTILYIRFQN 988

Mouse   900 QGRQVDDLEVWSHTNDTIGSVRRCILNRIK-ANVAHTKIELF-VGGELIDPGDDRKLIGQLNLKD 962
            .||.:||:|:.:|:|:|:.:.:|.:|.||| .:.|:.|::|| ...|:|...|:...:.|..::|
  Fly   989 PGRSIDDMEIVTHSNETMAAFKRNLLKRIKGTSTANIKVDLFYANDEMIGVSDEINPLYQYTIRD 1053

Mouse   963 KSLITAKLTQISSNMPSSPDSSSDSSTGSPGNHGNHYSDGPNP-------EVESCLPGVIMSLHP 1020
            |..:|||||.:.:.:.||||||||||||||          |.|       |.||.|||||:|.:.
  Fly  1054 KMNLTAKLTPVGTGLASSPDSSSDSSTGSP----------PRPCPDMQRVESESTLPGVIISQNY 1108

Mouse  1021 RYISFLWQVADLGSSLNMPPLRDGARVLMKLMPPDSTTIEKLRAICL-------------DHAKL 1072
            :|..|..::..|||.|....|||.|:||:.|:|.|..||.:|:.:|.             ..||.
  Fly  1109 QYTEFFLKLYQLGSDLEHGRLRDSAKVLLHLLPCDRQTIRQLKIMCKVPKAAVTVAVTGDKIAKD 1173

Mouse  1073 GESSLSP-------------SLDSLFFGPSASQVLYLTEVVYALLMPAGAPLTDDSSDFQFHFLK 1124
            .|..|.|             :.:.:|..|:.:||||...|::.||:||..||.:.:...|..::.
  Fly  1174 EEEKLYPTEQAGIEDEEEHCTPEQMFLHPTPAQVLYNLSVLHGLLIPALDPLGESALLVQSAWMH 1238

Mouse  1125 SGGLPLVLSMLTRNNFLPNADMETRRGAYLNALKIAKLLLTAIGYGHVRAVAEACQPGVEGVNPM 1189
            ||....||.:||:|||||:|||.|:|.::...|::|||.|..:|....|.          |..||
  Fly  1239 SGCAHFVLELLTKNNFLPSADMHTKRASFQCVLRLAKLFLYIVGSVLSRV----------GDEPM 1293

Mouse  1190 -TSVNQVTHDQAVVLQSALQSIPNPSSECMLRNVSVRLA-------QQISDEASR---------- 1236
             ..::..:..|..:|:....::|: ||:..||.:|.:||       ...|.|..|
  Fly  1294 ICDLDNGSRSQVDILKQNFSTMPS-SSQGTLRAISAKLAVILAREMLSASPEGDRCRTLFSSTLQ 1357

Mouse  1237 -YMPDICVIRAIQKIIWTSGCGGLQLVFSPN----EEVTKIYEKTNAGNEPDLEDEQVCCEALEV 1296
             ..|||..|:|:.::.|.|.||.||.:.:.:    :||.          .||.:|..:|.|||||
  Fly  1358 WSCPDISTIKAVVQLAWASSCGNLQALGNSSGDFEDEVI----------VPDGQDFSMCKEALEV 1412

Mouse  1297 MTLCFALIPTALDALSKEKAWQTFIIDLLLHCHSKTVRQVAQEQFFLMCTRCCMGHRPLLFFITL 1361
            :|:.|.|.|:|.:||:.:..|..||..::|....:.|||||.||.||..|.|....||.::.:.|
  Fly  1413 LTISFILNPSANEALTSDPNWPKFITSIVLKNPLRHVRQVASEQLFLASTYCAGDRRPFVYMVNL 1477

Mouse  1362 LFTVLGSTARERAKHSGDYFTLLRHLLNYA--YNSNINVPNAEVLLNNEIDWLKRIRDDVKRTGE 1424
            |...|.:...:......::|::|...|:|.  ||..:.:  :|.||.:||.||:|||::|..||:
  Fly  1478 LVGALKTLVPQYESTCAEFFSVLCRTLSYGCIYNWPLQI--SEGLLGDEIKWLQRIRENVHATGD 1540

Mouse  1425 TGVEETILEGHLGVTKELLAFQTPEKKFHIGCEKGGANLIKELIDDFIFPASNVYLQYMRNGELP 1489
            |.|.|.:|||||.:.|||:.|...:.|..:.      .||.||||||:|.||..:|...|:|.|.
  Fly  1541 TQVHEELLEGHLCLAKELMFFLGADSKAQLN------ELIHELIDDFLFTASREFLHLRRHGSLR 1599

Mouse  1490 AEQA-IPVCGSPATINAGFELLVALAVGCVRNLKQIVDSLTEMYYIGTAITTCEALTEWEYLPPV 1553
            .:.. .|||.||.||.|..:||:||...||.|:|.:.::|     |....|..:.|.||:|||||
  Fly  1600 QDTVPPPVCRSPHTIAAACDLLIALCQLCVPNMKLLTNTL-----IDFVCTDTDPLREWDYLPPV 1659

Mouse  1554 GPRPPKGFVGLKNAGATCYMNSVIQQLYMIPSIRNGILAIEGTGSDVDDDMSGDEKQDNESNVDP 1618
            |.||.|||.||||||||||||||:|||||:|::|.|||...|..:...:|.|||   .:.:....
  Fly  1660 GARPTKGFCGLKNAGATCYMNSVLQQLYMVPAVRVGILRAHGAATTDGEDFSGD---SDLTGGGL 1721

Mouse  1619 RDDVFGYP-QQFEDKPPLSKT-ED-----RKEYNIGVLRHLQVIFGHLAASRLQYYVPRGFWKQF 1676
            ...:|..| ......|..|.| ||     ||.|::.:|:|:|.||.||..|.||||||||.|..|
  Fly  1722 GSALFSGPASALVSLPSSSSTIEDGLHDVRKNYHVVILKHVQAIFAHLGHSALQYYVPRGLWTHF 1786

Mouse  1677 RLWGEPVNLREQHDALEFFNSLVDSLDEALKALGHPAMLSKVLGGSFADQKICQGCPHRYECEES 1741
            :|.|||||||||.||:|||.||::||||.|||||.|.:::..|||||:||||||.|||||..||.
  Fly  1787 KLLGEPVNLREQQDAVEFFMSLLESLDEGLKALGQPQLMNATLGGSFSDQKICQECPHRYSKEEP 1851

Mouse  1742 FTTLNVDIRNHQNLLDSLEQYVKGDLLEGANAYHCEKCNKKVDTVKRLLIKKLPPVLAIQLKRFD 1806
            |:..:||||||.:|.:||||||||:|||||:||||:||:|||.||||:.:||||||||||||||:
  Fly  1852 FSVFSVDIRNHSSLTESLEQYVKGELLEGADAYHCDKCDKKVVTVKRVCVKKLPPVLAIQLKRFE 1916

Mouse  1807 YDWERECAIKFNDYFEFPRELDMEPYTVAGVAKLEGDNVNPESQLIQQNEQSESEKAGSTKYRLV 1871
            ||:||.|||||||||||||.||||||||:|:|||||:.|.     :..|.|:..|   :|||.|.
  Fly  1917 YDYERVCAIKFNDYFEFPRILDMEPYTVSGLAKLEGEVVE-----VGDNCQTNVE---TTKYELT 1973

Mouse  1872 GVLVHSGQASGGHYYSYIIQRNGGDGEKNRWYKFDDGDVTECKMDDDEEMKNQCFGGEYMGEVFD 1936
            |::|||||||||||:|||:.:|..:| |.:|||||||:||||||.:|||||.:|||||||||.:|
  Fly  1974 GIVVHSGQASGGHYFSYILSKNPANG-KCQWYKFDDGEVTECKMHEDEEMKAECFGGEYMGETYD 2037

Mouse  1937 HMMKRMSYRRQKRWWNAYILFYERMDTIGHDDEVIRY---ISEIAITTRPHQIV-MPSAIERSVR 1997
            :.:|||.|||||||||||:|||.|.     |...::|   :.::::....:.:: :|..||||||
  Fly  2038 NNLKRMQYRRQKRWWNAYMLFYTRC-----DQTPVQYEPSVEQLSLAESRNMVLPLPKPIERSVR 2097

Mouse  1998 KQNVQFMHNRMQYSLEYFQFMKKLLTCNGVYLNPPPGQDHLSPEAEEITMISIQLAARFLFTTGF 2062
            .||::|:|:|..:|:|:|.|:|||::||.:...    .:.::|.|||::::.:|||::|||.|||
  Fly  2098 HQNIRFLHSRSIFSVEFFNFIKKLVSCNLLSAR----SNKITPAAEELSLLGVQLASQFLFHTGF 2158

Mouse  2063 HTKKIVRGSASDWYDALCILLRHSKNVRFWFAHNVLFNVSNRFSEYLLECPSAEVRGAFAKLIVF 2127
            .|||.:||...:|||||...:|.|..||.|||::.|.:..:|..||:|..||.:||..|.||:||
  Fly  2159 RTKKSLRGPVMEWYDALSHHIRSSALVRKWFANHALLSPPSRLGEYILMAPSPDVRTVFVKLVVF 2223

Mouse  2128 IAHFSLQDGPCPSPFASPGPSSQAYDNLSLSDHLLRAVLNLLRREVSEHGRHLQQYFNLFVMYAN 2192
            ..||::.|.|.           ..||..:|.:.:|.:||.||:.|.:::|:||..||:||.||..
  Fly  2224 FCHFAINDEPL-----------TGYDGANLCEQVLISVLRLLKSEAADYGKHLPHYFSLFSMYVG 2277

Mouse  2193 LGVAEKTQLLKLSVPATFMLVSLDEGPGPPIKYQYAELGKLYSVVSQLIRCCNVSSRMQSSINGN 2257
            ||..||.|||:|:||..|:.|:||:||||.|||||.|..||:.|||.||||.:||.:.|||....
  Fly  2278 LGTREKQQLLRLNVPLQFIQVALDDGPGPAIKYQYPEFSKLHQVVSHLIRCSDVSEKCQSSNQNA 2342

Mouse  2258 PSLPNPFGDPNLS-QPIMPIQQNVVDILFVRTSYVKKIIEDCSNSDETVKLLRFCCWENPQFSST 2321
            ..|.|||.|||:: :.:.|:....:|:||.||.|:||:|||.:..||.:|||::|.||||.||..
  Fly  2343 RPLSNPFKDPNVAHEELTPLSTECMDLLFNRTGYIKKVIEDTNVGDEGLKLLQYCSWENPHFSRA 2407

Mouse  2322 VLSELLWQVAYSYTYELRPYLDLLLQILLIEDSWQTHRIHNALKGIPDDRDGLFDTIQRSKNHYQ 2386
            ||:|||||..::|.:::|.:.||||.||||:||||.|||||||.|:.::|:||.:||||:|.|||
  Fly  2408 VLTELLWQCGFAYCHDMRHHTDLLLNILLIDDSWQHHRIHNALNGVAEEREGLLETIQRAKTHYQ 2472

Mouse  2387 KRAYQCIKCMVALFSSCPVAYQILQGNGDLKRKWTWAVEWLGDELERRPYTGNPQYTYNNWSPPV 2451
            |||||.|||:..||...|:|.|:|..|.::.|.|:.|||||..||:|:...| .||...:||||.
  Fly  2473 KRAYQIIKCLTQLFHKSPIALQMLHTNSNITRHWSIAVEWLQGELDRQRGIG-CQYNSYSWSPPA 2536

Mouse  2452 QSNETSNGYFLERSHSARMTLAKACELCPEEVKKATSLQEIEMEESKEPDDQDAPDEHESPP 2513
            |||:.:|||.||||.||:.|.:.|.||||:||.:.|       :|:.||:.:...||::|.|
  Fly  2537 QSNDNTNGYMLERSQSAKNTWSMAFELCPDEVSEKT-------DENNEPNLETNMDENKSEP 2591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp9x	XP_006527649.1	Ubiquitin_like_fold	<905..969	CDD:391949	22/65 (34%)
		peptidase_C19C	1560..1963	CDD:239124	255/409 (62%)
faf	NP_524612.2	peptidase_C19C	1666..2064	CDD:239124	255/414 (62%)
		UCH	1668..2059	CDD:278850	250/402 (62%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1237	1.000	Domainoid score	I10
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3418
Inparanoid	1	1.050	2269	1.000	Inparanoid score	I38
Isobase	1	0.950	-	0	Normalized mean entropy	S4546
OMA	1	1.010	-	-		QHG58606
OrthoDB	1	1.010	-	-		D22076at33208
OrthoFinder	1	1.000	-	-		FOG0002455
OrthoInspector	1	1.000	-	-		otm44109
orthoMCL	1	0.900	-	-		OOG6_102574
Panther	1	1.100	-	-	LDO	PTHR24006
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4564
SonicParanoid	1	1.000	-	-		X1635
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.820