Protein Alignment Usp9x and Usp15-31

DIOPT Version :10

• Sequence 1: XP_006527649.1
• Gene: Usp9x / 22284
• MGIID: 894681
• Length: 2575
• Species: Mus musculus
• Sequence 2: NP_611959.2
• Gene: Usp15-31 / 37954
• FlyBaseID: FBgn0050421
• Length: 1272
• Species: Drosophila melanogaster
• Alignment Length: 1122
• Identity: 208/1122 - (18%)
• Similarity: 347/1122 - (30%)
• Gaps: 404/1122 - (36%)

Mouse   933 AHTKIELFVGGELIDPGDDRKLIGQLNLKDKSLITAKLTQISS-NMPSSPDSSSDSSTGSPGNHG 996
            :||.|...|||     |..|              :..:..:|| ..|....::::::|.|.||:.
  Fly   108 SHTAISSCVGG-----GRGR--------------SGSIVSLSSYEAPFISSTNNNTTTASNGNNN 153

Mouse   997 NHYSDGPNPEVESCLPGVIMSLHPRYISFLWQVAD-LGSSLNM------PPLRDGARVLMKLMPP 1054
            |..|...|.:....|      ....:..||.::|. |.|::|:      .|..   |:....:.|
  Fly   154 NSSSSNINSKRTRAL------RRSSFRKFLNRIAQHLSSTVNVVSEEKHSPAN---RIAFIEIVP 209

Mouse  1055 DSTTIEKLRAICLDHAKLGESSLSPSLDSLFFGPSASQVLYLTEVVYALLMPAGAPLTDDSSDFQ 1119
            ..|...:.:    :..|.|:.|:|.|......|...               |.|.........:|
  Fly   210 FYTGCWRRK----EANKHGQPSVSGSSSGGGGGAGG---------------PGGGERVPPIGGYQ 255

Mouse  1120 FHF--------LKSGG----LPLVLSMLTRNNFLP--------NADMETRRGAYLNALKIAKLLL 1164
            :..        ||:.|    :..||..|:..:.|.        .||::.|.  .:|:.|.
  Fly   256 WPADQTPGVMGLKNHGNTCFMNAVLQCLSHTDILAEYFVLDQYKADLKRRN--KINSRKF----- 313

Mouse  1165 TAIGYGHVRAVAEACQPGVEGVNPMTSVNQVTHDQAVVLQSALQSIPNPSS-----ECMLRNVSV 1224
                             |.:|        ::|...|.||: ||.:..|.|.     :.::.....
  Fly   314 -----------------GTKG--------ELTEQLANVLK-ALWTCKNESDHSTSFKAVVDRYGT 352

Mouse  1225 RLAQQISDEASRYMPDICVIRAIQKIIWTSGCGGLQLVFSPNEEVTKIYEKTNAG---------N 1280
            :.......:|..:            :.|.               :.|::|..|..         |
  Fly   353 QFRSSTQHDAQEF------------LFWL---------------LDKVHEDLNTASKRRYKSLKN 390

Mouse  1281 EPDLEDEQVCCEALEVMTLCFALIPTALDALSKEKAWQTFIIDLLLHCHSKTVRQVAQEQF--FL 1343
            .....||.:..|.|...                            :.|::..|:.|.|.||  .|
  Fly   391 SYGRSDEVIAAETLANH----------------------------IRCNNSFVQAVFQAQFRSSL 427

Mouse  1344 MCTRC-----------CMG-HRPLLFFITLLFTVLGSTARERAKHSGDYFTLLRHLLNYAYNSNI 1396
            .|.||           |:. ..|.|...|:..||:..|...|....|                 :
  Fly   428 TCPRCEKQSNTFDPFHCISVQLPQLTQQTIFVTVVYMTRLPRQVRMG-----------------L 475

Mouse  1397 NVPNAEVLLNNEIDWLKRIRDDVKRTGETGVEETIL-------EGHLGVTKELLAFQTPEKKFHI 1454
            .||....::        .:|:.::  .:||:|.:.:       ||...|..:....:|......|
  Fly   476 RVPAGSPIV--------ALREQLQ--ADTGIEGSRMVLVDLNAEGFTRVFYDTQPVETLSSIETI 530

Mouse  1455 GCEKGGANLIKELIDDFIFPASNVYLQYMRNGELPAEQAIP--VCGSPATINAGFELLVALAVGC 1517
            .|.:              .||:....:.....| ..:::.|  |..|||...:..:||:.:|
  Fly   531 YCIE--------------VPAATPVAKAATPSE-TGDKSAPTAVTPSPAAAQSQADLLLLVA--- 577

Mouse  1518 VRNLKQIVDSLTEMYYIGTAITTCEALTEWEYLPPVGPRPPKGFVGLKNAGATCYMNSVIQQLY- 1581
              |:.:..|        |..||...|        |...:.|:          .|....:.:::.
  Fly   578 --NVYRAKD--------GADITRFGA--------PFSMKAPR----------DCSYQDLQKRMLR 614

Mouse  1582 -MIPSIRNGILAIEGTGSDVDDDMSGDEKQDNESNVDPRDDVFGYPQQFEDKPPLSKTEDRKEYN 1645
             |.|.::..:.:.....:    :|.....|      ||..|...|.:|.| .|.|::..|..
  Fly   615 EMAPLLKPEVFSYATPLA----EMFRIRLQ------DPSADPDTYLEQVE-HPLLTEMIDMA--- 665

Mouse  1646 IGVL------RHLQVIFGHLAASRLQYYVPRGFWKQFRLWGEPVNLREQHDALEFFNSLVDSLDE 1704
            :.||      :|::::..                     |..|    |.|     |.|.....:|
  Fly   666 LSVLSSEAGPQHIKLLLE---------------------WSSP----EAH-----FISKQQDTEE 700

Mouse  1705 ALKALGHPAMLSKVLGGSFADQKICQGCPHRYECEESFTTLNVDIRNHQNLLDSLEQYVKGDLLE 1769
            |:......|.||.......|...:.|       |                    ||.|.|.:.|.
  Fly   701 AVVEHESVARLSASKPSDTAALTLEQ-------C--------------------LEHYTKAETLS 738

Mouse  1770 GANAYHCEKCNKKVDTVKRLLIKKLPPVLAIQLKRF-DYDWERECAIKFNDYFEFP-RELDMEPY 1832
            ..:|:.|..|.:.:..||.|.:..||.:|.:..||| .:..:...|.|.....:|| ...||.|:
  Fly   739 AEDAWRCPHCQQYLPVVKTLGLWSLPDILVVHFKRFRQHQSKGPQAAKLTTMVKFPLTAFDMSPH 803

Mouse  1833 TVAGVAKLEGDNV--------------NPESQLIQQNEQSESEK----AGSTKYRLVGVLVHSGQ 1879
            ...||.:....::              ||..:....:.:|.:..    |..|:|.|..|..|.|.
  Fly   804 LARGVHESASSSLGMGTGIGLGLGLGSNPWKKARSVDSRSSTLNSRCDAKDTRYDLYAVCYHQGD 868

Mouse  1880 A-SGGHYYSYIIQRNGGDGEKNRWYKFDDGDVTECKMDDDEEMKNQCFGGEYMGEVFDHMMKRMS 1943
            . ..|||.:..  :|..|   .:||||||..|::...||.|:            ::.::
  Fly   869 TLETGHYTAAC--KNPYD---RQWYKFDDQRVSKVPEDDIEQ------------DIINN------ 910

Mouse  1944 YRRQKRWWNAYILFYER 1960
                    .||:|||:|
  Fly   911 --------EAYMLFYQR 919

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp9x	XP_006527649.1	Ubl1_cv_Nsp3_N-like	<905..969	CDD:475130	8/35 (23%)
		peptidase_C19C	1560..1963	CDD:239124	88/430 (20%)
		DUF3517	2102..2481	CDD:463438
Usp15-31	NP_611959.2	UBP12	<255..921	CDD:227847	171/928 (18%)