DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ush2a and wb

DIOPT Version :9

Sequence 1:NP_067383.3 Gene:Ush2a / 22283 MGIID:1341292 Length:5193 Species:Mus musculus
Sequence 2:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster


Alignment Length:3091 Identity:567/3091 - (18%)
Similarity:852/3091 - (27%) Gaps:1436/3091 - (46%)


- Green bases have known domain annotations that are detailed below.


Mouse   306 PRVHPSVQQYCIPNGA-------GDTP-----EHRMSRLNPEAHPLSFINDDDVATS-------- 350
            ||...||...|..|||       |..|     .|...|....:.. |.|:....:.|        
  Fly   162 PRAQISVNATCGQNGAEEYCKQVGAKPCGICNAHSSDRAKQRSIQ-SLISSGSGSGSGSGFEEGW 225

Mouse   351 WISHVFTNITQLYEGVAISIDLENGQYQVLKVITQFSSLQPVAIRIQRKKADSSPWEDWQYFA-- 413
            |.|.......| :|.|.|.:||:. .:|:..|..:.::....|..|..|..|...:|.||||.  
  Fly   226 WQSPTLQGGRQ-FEYVTILLDLKQ-TFQIFSVWLKSANSPRPASWILEKSLDGINFEPWQYFGLS 288

Mouse   414 -----RNCSVWGMKDNEDLENPNSVNC-LQLPDFIPFSHGNVTFDLLTSGQKHRPGYNDFYNSSV 472
                 |..::.|.......:|...:.| .|.....|..:|.:...||    |:|||..|  .|..
  Fly   289 DADCQRRWNLSGQNGKYVFQNDTEIICSTQFSKPGPLENGVLHASLL----KNRPGATD--QSPE 347

Mouse   473 LQEFMRATQIRLHFHGQYYPAG--HTVDW--------RHQYYAVDEIIVSGRCQCHGHAETCDRT 527
            |.:|:....||:...|.:..|.  :::||        :|.:|::.::.||.|..|:|||.....:
  Fly   348 LMKFITTRYIRIRLQGMHSTANQDNSLDWLLDSPSLEKHSFYSLSQLKVSARLDCNGHANRSHES 412

Mouse   528 RRP----YRCLCSPHSFTEGPQCDRCSPLYNDKPFRSGDNVNAFNCKPCQCHGHASSCHYDASVD 588
              |    .:|:|. |: |.|.||::|.||:.|:|::.|.     .|:.|||:|||.||.||..:|
  Fly   413 --PDDPLMQCICQ-HN-TCGAQCEQCCPLFQDRPYQMGG-----ECEICQCYGHAESCTYDPFLD 468

Mouse   589 PFPLEHNRGGGGVCDDCQHHTTGRHCESCQDYFYRPVGA---DPAAP------------------ 632
            .          |:|..|.::|.|..||.|:..|||.:.|   ||..|                  
  Fly   469 K----------GICQSCSNNTAGIECEFCEMGFYRELDAPLTDPCLPCSCNPARSTGGCQSDGGS 523

Mouse   633 ---------------------DACKLCDCNRAGTRNGSLHCDPIGGQCDCKRRVSGRQCLQCQDG 676
                                 |.||.|:|:..|:...:..|   .|.|.||..|.|..|.:|..|
  Fly   524 CNCLEGFQGKNCEECAPGYYGDDCKRCECDERGSLGSTGSC---SGVCQCKLNVEGSTCSECAPG 585

Mouse   677 FYDLQALDPDGCRPCNCN----------------------------------------------- 694
            ::||.|.:.:||..|.|:                                               
  Fly   586 YFDLSAENAEGCTSCWCSGVSQTCHSAKLQTLAFETLNDWKITDIQRVKPISIPVDAETNRLIFA 650

Mouse   695 ----------------------------------------------------------------- 694
                                                                             
  Fly   651 NELDEVEAIYWQASLGYLGNRLTSYGSRLQLVLSWDVIRGDRSGKPTTGPNVILVGKNGLKIAFG 715

Mouse   695 -----------------------PSGTVD----------GD------------------------ 702
                                   |...||          ||                        
  Fly   716 DESLDGLGINLNVTLTEVGWYHVPPTVVDIKTRLRRTEGGDYHGESVTRSQFLSVLVSLDAVLIR 780

Mouse   703 ITCHQNSG-------------------------QCSCKANVIGLRCNRCNFGFK----------- 731
            ...|.:.|                         ||.|.|...||.|..|.||||           
  Fly   781 AAFHTDQGETSLERAVIYSGGVELGGKSSSQVEQCLCPAGYTGLSCEGCAFGFKRIYENTSDHQI 845

Mouse   732 ----------------FLQSFN---------GDGCEPCQ-------------------------- 745
                            .|||.|         ||.||.||                          
  Fly   846 LSKCIPCPCNGHSNSCDLQSGNCGDCMHNTFGDRCERCQLGYYGNPLQGTPNDCKRCACPLSEDS 910

Mouse   746 ------CNLH-----------------------------------------------GSVNQLCD 757
                  |.|.                                               ||..|.||
  Fly   911 NNFSPSCQLKSYNYMDLNPQFELIEHAEYICTQCPEGYTGDHCQVCDDGYFGNPRQPGSSCQRCD 975

Mouse   758 PLSGQC--------ACKKEAKGLKCDSCRENFYGLPWSACEVCDCSKAGSQPGTVCDTETGQCVC 814
            ...|.|        .|:...:|..|:.|:..::|.|...|:.|.|...||:.| :||:..|||:|
  Fly   976 CAGGPCNVTTGECITCRGNTEGWHCERCKLGYWGDPAVGCDPCHCHTEGSESG-LCDSTDGQCLC 1039

Mouse   815 KPNVGGRQCSQCKAGYFNLYQNDSHLCLTCNCEKMGTVNGSLRCDKSTGQCPCKLGVTGLRCHQC 879
            ||...|::|.:|..||.|:...    |.:|||:.:|::... |||..||||.||.||.|.:||:|
  Fly  1040 KPRYAGQKCDECDVGYANVELR----CPSCNCDPLGSLVQD-RCDPHTGQCHCKEGVMGAKCHEC 1099

Mouse   880 KPHRFNLT-----MD-----------------------NPQ-----GCQACDCDSLGTLPGSMCD 911
            :...|.:.     ||                       :|.     .|:.|.|.|:|:| .|.||
  Fly  1100 QDGYFGMNAVAYRMDDLAALRQNSDSDDDEWELVPDTEDPNSESTVACEECHCSSVGSL-SSDCD 1163

Mouse   912 PISGQCLCLPHRQGRRCEQCQPGFYSSPSNATGCLPCLCHTAGAVSHICNSVTGQCSCHDPSTTG 976
            ..:|||.||.:..||||::|:||.::..: ..||..|.|...|:..|.||..||||.| .....|
  Fly  1164 KRTGQCACLANVTGRRCDKCRPGHWNLTA-GEGCRDCRCDPHGSRGHECNPWTGQCDC-KIGVGG 1226

Mouse   977 RSCHQCQESYFRF------------------DPLTGR---------------------------C 996
            :.|::|.|.:|.|                  ||..||                           |
  Fly  1227 QHCNECTEGFFGFSTEGCQRCSACRSEGQVCDPHNGRCICPKFTRGLGCGQCVPGTWGWQARLGC 1291

Mouse   997 RPCHC-HVA-----------------GASNGTCDAV----------------------------- 1014
            |.|.| |:.                 |.|...||..                             
  Fly  1292 RECECDHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIGYFGYPECRRCGCDAEGSFTQADGSIA 1356

Mouse  1015 ---TGQCFCKEFVTGSKCDTCVPGASHLDVNNLLGCSK--------TPSQQPPPRGWVQSSSTIN 1068
               .|||.||..|.|.|||||:.....|...|..||::        ...|.....|.::.:.:.|
  Fly  1357 CDSNGQCPCKSLVVGLKCDTCMQSTFGLSAQNPEGCTRCFCFGRSGECEQSDLSWGHIRMAESRN 1421

Mouse  1069 VSWS---PPECPNAHWLTY---------TLFRNGSEIYTTED-------------------EHPY 1102
            :|..   |...|::.: .|         :..|..:||....|                   .||.
  Fly  1422 LSVQQIRPHSVPSSDY-EYIVVVQMEGSSFHREDAEIQRMNDLSLVPKSTGNVSIGAYGQFYHPL 1485

Mouse  1103 YTQ---YFLDTSLSPHTAYSYY----------IETS--------NVHSSTRSIPVIYETKPEVSE 1146
            |.|   .|.....|.:..:.|:          :|.:        .:|:.::.:...||.  |..|
  Fly  1486 YFQLPPQFYGDRTSSYGGFLYFTLITEGAHKPLERNILGQYPLVQLHAHSKLLLDFYEY--EEFE 1548

Mouse  1147 GHLNLTHIIPV------------GSDSITLTWTGLSN---------------------------- 1171
            ..||:||.:|:            ..|..|| ...|.|                            
  Fly  1549 YSLNVTHRVPLHESFWKYHHTSQAVDRNTL-MAALQNIRHIFIRAFAFADFQEVVLQNVHMDAAI 1612

Mouse  1172 ----SSDPVAKYV-----------LSC-------------TPVDS-------------------- 1188
                |::.:||.|           |||             |.|:|                    
  Fly  1613 YIKGSTNLIAKGVERCKCPKRFDGLSCQDPGRSFYRWRNTTIVESVFIEDLIGRAAPCHCNGRSS 1677

Mouse  1189 -----TEPCVSYEG-----------------------------PETS------ATIWNLVPFTQY 1213
                 |..|.:..|                             |||:      ..:|:   ....
  Fly  1678 DCDRETGVCQNCRGNTGGDHCHQCAEGFYGDPNSPHGCQACPCPETNRNFARGCNVWD---GEVS 1739

Mouse  1214 CFSVQGCTNESC------FYSLPIIVTTAQAPP--------QTQG-------------------- 1244
            |....|.|...|      ::..|:........|        ||:|                    
  Fly  1740 CVCKPGYTGRLCERCQAGYFGDPMRYPNTTCQPCNCHPDGIQTEGCDVETGRCYCREGVTGLKCD 1804

Mouse  1245 -----------------------------------------------PPTV-------------- 1248
                                                           |...              
  Fly  1805 KCQAERHHLVDNGCKICDNCTLLLLDYMELVGNKLRRGMHNMDLTGIPAPYRKLSEYESAYEKWN 1869

Mouse  1249 ---WKISPTELRIEWSPPVDSNGII------ISYELYMRRWLST-----------EESLVFESH- 1292
               |..|.|:.|::   ..||..|:      .:.:...|:.::|           .|..|.:.| 
  Fly  1870 GRHWDFSQTKRRLQ---DYDSADILKLEAHAENLKFQSRKAVATIGKREFAIKSMREDAVTQQHS 1931

Mouse  1293 -GLVSSH-----SALQSVNPSKNLLQQP----QASTFISGLEPHTEYAFRVLAVN---------- 1337
             ||:.|.     |.|.....|.:.|..|    ||..::..:..|.:....:.:.|          
  Fly  1932 VGLLRSEILQTLSDLHGYGKSAHYLSLPTALKQARFYLQAIREHDQMVQGIRSTNDCAWKHFYAM 1996

Mouse  1338 ---------MAGRVSSAW------------------------------------ASERTGES--- 1354
                     .:||:...|                                    .|.|.|||   
  Fly  1997 GNASDASFDESGRLEMLWRDLNQTNHRVVDMRLQVDRVQEVENEAEDVLEHVRNLSIRVGESHQE 2061

Mouse  1355 -------VPVFMAP--------------------------------------------------- 1361
                   :...:.|                                                   
  Fly  2062 LDELNQRISDHLDPGYLEQGEGLLRLTVQRQIMLNGHLNQLDGYRILLNTTLGVKTEQQREVRKH 2126

Mouse  1362 --PSVSPLSPHSLSVSWE-----KPAENFTR---------------------------------- 1385
              |.....:.|.|:.|.|     :|..|..|                                  
  Fly  2127 WLPKAEKHASHLLARSNEYARKFQPTRNGARIAMLASSAHSNITEAINDARLASILAKERVYEAQ 2191

Mouse  1386 ----------------------------------------------------------------- 1385
                                                                             
  Fly  2192 RTLYPSDGSSMIERAKHSLHRSKQLQQEALKQMHKSNVLKDKLHRQEQQVEGIKSTIYDSGLRTN 2256

Mouse  1386 ---GEIIG-----------------------------------------------------YKIS 1394
               |::.|                                                     .|:.
  Fly  2257 NISGQLQGLSDGSARRQAKDSLEMADRTGEQMRAELQKAKDMQKSIQNMRNSFSNLEPDWEIKLG 2321

Mouse  1395 MVSEHFPLHDVPV-------------------------------------MCSKMVHFAKSQDQS 1422
            |..|:..|....:                                     ..:|..|.|::.|.|
  Fly  2322 MAQENISLTQTNLRLANVSLSYLEQQAEKEQQVFEVWNNSMAQQLQQLRDQIAKARHAAEAIDVS 2386

Mouse  1423 YIVRGLEPYRTY---------------SFTVS----------LCDSVG-CVTSAL---------G 1452
            ....|.:..|:|               ||.:|          |..|.| .:|..|         .
  Fly  2387 LESLGPKCIRSYLPASYGLSTSNKIRMSFALSNHLESSPLIHLASSEGRHITLELYKRRVRLVWN 2451

Mouse  1453 SGQTLAAAP--------------------------------------AQLRPP---MVTGVNSTT 1476
            .|.|.|...                                      .:|.||   ::|| ::.|
  Fly  2452 LGGTTATVTHPMVVHTRDPKYDDAWYHVEANRTLNLGSLVVRRMNNYGELTPPNPVIITG-STDT 2515

Mouse  1477 VHIR--------------------WLPPAGV--------NGPPPLYHLERKKSSLPAA------T 1507
            .|.|                    :.|...|        |.|..|::....:.|...:      :
  Fly  2516 EHTRFYQSRSDRISLGGFASKDLQFTPGLNVVVHQVEVDNKPLGLWNFVTSEGSCGGSMVGAKES 2580

Mouse  1508 AAVTKGTRFVGHGYCRF----PRTAHADFIGIKASFRTRVPEGLILLALSPGDQEEYFTLQLKNG 1568
            :|.:....|.|.||.:.    ||....:...::.:|||.....|:.||:...:... .::.|..|
  Fly  2581 SASSTARHFNGLGYAQLMKTRPRPTRKNLFSVQMTFRTLDENALLFLAVDDKNNRS-VSVTLSRG 2644

Mouse  1569 RPYFL--YNSQGTLVEVTPTDDPSQGYRDGEWHEIIAVRHQAFGQITLDGQYTGSSSSLNGSSVT 1631
            |..|.  |..:..| |:..|    :.|..|:|.:|.|.|..:..:.|.:|....:    |...::
  Fly  2645 RIMFRIDYGDESKL-EINTT----KKYNVGQWIKIEAAREFSAKRSTENGMLRVN----NDRPIS 2700

Mouse  1632 G--------------GYTGLFVGGVPQGHSVLQKRLEIIQRGFVGCLKDVFIMKGYSPSG-TWLP 1681
            |              ..|..::||||.|.:....:.......|:||:|||.:      :| |:.|
  Fly  2701 GAPTLPVNIHLLPDLSKTVYYLGGVPPGFTSGTSKAPGADNPFLGCMKDVQV------NGETYDP 2759

Mouse  1682 LDWQSSEEQVNVHPSWEGCPTNLEEGVQFLGAGFLELPSDTFHAAKDFEISLKFQTDQLNGLLL- 1745
            |:   |.....|.||.:    |:.....|.|.|:|||||.:..  |....:|.|:|.|.:.||| 
  Fly  2760 LE---SSSYYGVEPSCK----NMITKAGFSGNGYLELPSQSLR--KRSNTALVFRTLQPDCLLLL 2815

Mouse  1746 ------FIHNTEGPDF---LAVELKRGLLSFKFNSSLVFTRVDLRLGLADCDGKWNTVSIKKEGS 1801
                  .:.:.:..|.   .::.|..|.|....||...|.::.......: ||:::.|.:.|.|.
  Fly  2816 AAYPPEILGDYDAKDIKGNFSISLVDGQLHVWVNSGRSFIKMSSNSSQMN-DGEFHVVHLIKTGR 2879

Mouse  1802 VVSVRVNALKKSTSQAGGQPLLVNSP-----VYLGGIPRELQDAYRHLTLEPGF---RGCVKEVA 1858
            .:.:.|:...:......|.|.:|:.|     :|:||.|.  .::|  ..|.|.|   .|.:::|.
  Fly  2880 KLELMVDDELQEIRNLNGNPTVVSLPRDAGGLYIGGAPP--HESY--TPLAPTFVNLEGAIRDVV 2940

Mouse  1859 FARGVVVNLASVSSRAVRVNQDGCLSSDSTVNCGGNDSILVYR----GSQQSVYESGLQPFTEYL 1919
            |....:....:::...|::.::|.|.....   ||...:|:..    |...:....|.:....|.
  Fly  2941 FNNRTINFNDALTFANVQIGRNGPLMGSLK---GGLYDVLLKTEPMIGKSFTASPEGCKRIGSYS 3002

Mouse  1920 YRVTASHEGGAVSS----------DWSRGRTLG-------------TAPQSVPTPSRAQSI---N 1958
            |...|...|..:.|          .|.|...|.             .:|.|...|....::   :
  Fly  3003 YEPNAFKFGDDIYSYSQLKLPERHFWQRNFHLSFDFRSFYPNGMLYLSPGSKEKPKHYVALVLKD 3067

Mouse  1959 GSSVEVAWNEPAVVKG-VLEKYVLKAYSEDSSQPRVPSASTELHDTSTHSGVLIGLHPFHSYTVT 2022
            |..|       .||:| ..|:..|.|...|....||   :...||......|.|| ......:..
  Fly  3068 GQLV-------LVVRGRRREELQLTAKLNDGEWHRV---TISCHDRKVTMSVEIG-RTDQKTSAQ 3121

Mouse  2023 LTACSRAGCTESSQALSISTPQEAPQEVQAPVAVAL 2058
            :....:.|   :||.|.:....::|.:|.:.:.|.|
  Fly  3122 MKLPKKIG---ASQLLLVGGLPQSPVKVSSDLYVRL 3154

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ush2aNP_067383.3 LamGL 145..280 CDD:214722
Laminin_N 313..513 CDD:295486 56/237 (24%)
EGF_Lam 514..562 CDD:238012 18/51 (35%)
EGF_Lam 571..636 CDD:238012 27/106 (25%)
Laminin_EGF 638..688 CDD:278482 16/49 (33%)
Laminin_EGF 691..741 CDD:278482 27/279 (10%)
EGF_Lam 743..788 CDD:238012 17/131 (13%)
EGF_Lam 792..832 CDD:214543 18/39 (46%)
Laminin_EGF 844..894 CDD:278482 23/82 (28%)
EGF_Lam 896..945 CDD:238012 20/48 (42%)
EGF_Lam 947..997 CDD:238012 21/94 (22%)
EGF_Lam 998..>1035 CDD:238012 19/86 (22%)
fn3 1055..1128 CDD:278470 18/124 (15%)
FN3 1153..1235 CDD:238020 29/215 (13%)
FN3 1239..1351 CDD:238020 33/286 (12%)
FN3 1362..1445 CDD:214495 27/304 (9%)
Laminin_G_2 1539..1669 CDD:280389 36/145 (25%)
LamG 1707..1857 CDD:238058 42/167 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1931..1955 7/46 (15%)
FN3 1947..2042 CDD:238020 22/98 (22%)
FN3 2134..2230 CDD:238020
FN3 2232..2304 CDD:238020
FN3 2320..2419 CDD:238020
FN3 2423..2516 CDD:238020
FN3 2524..2610 CDD:238020
FN3 2612..2710 CDD:238020
FN3 2715..2807 CDD:238020
FN3 2809..2911 CDD:238020
FN3 2916..2993 CDD:238020
FN3 <3441..3486 CDD:238020
FN3 3582..3668 CDD:238020
FN3 3672..3753 CDD:238020
FN3 3769..3854 CDD:238020
FN3 3867..3952 CDD:238020
FN3 3956..4053 CDD:238020
FN3 4153..4239 CDD:238020
FN3 4260..4343 CDD:238020
FN3 4348..4431 CDD:238020
FN3 4435..4519 CDD:238020
FN3 4521..4619 CDD:238020
FN3 4645..4722 CDD:238020
FN3 4724..4800 CDD:238020
FN3 4817..4918 CDD:238020
PDZ-binding 5191..5193
wbNP_723870.1 Laminin_N 164..396 CDD:278484 57/240 (24%)
EGF_Lam 401..450 CDD:238012 18/57 (32%)
TNFRSF <407..507 CDD:304602 41/118 (35%)
EGF_Lam 505..552 CDD:238012 5/46 (11%)
Laminin_EGF 550..597 CDD:278482 16/49 (33%)
Laminin_B 660..798 CDD:278481 7/137 (5%)
EGF_Lam 851..900 CDD:238012 10/48 (21%)
Laminin_EGF <943..971 CDD:278482 2/27 (7%)
VSP 953..1414 CDD:146106 128/469 (27%)
Laminin_EGF 974..1018 CDD:278482 11/43 (26%)
EGF_Lam 1017..1065 CDD:238012 20/52 (38%)
Laminin_EGF 1065..>1105 CDD:278482 19/40 (48%)
EGF_Lam 1150..1197 CDD:238012 21/48 (44%)
Laminin_EGF 1199..1247 CDD:278482 17/48 (35%)
EGF_Lam 1247..1292 CDD:238012 4/44 (9%)
Laminin_EGF 1294..1342 CDD:278482 7/47 (15%)
Laminin_EGF 1340..1392 CDD:278482 14/51 (27%)
Laminin_B 1486..1611 CDD:278481 21/127 (17%)
EGF_Lam 1669..1716 CDD:238012 3/46 (7%)
Laminin_EGF 1718..1767 CDD:278482 9/51 (18%)
EGF_Lam 1772..1819 CDD:238012 4/46 (9%)
CrfC <1933..2267 CDD:223771 31/333 (9%)
Laminin_II 2277..2400 CDD:283628 12/122 (10%)
LamG 2399..>2492 CDD:304605 11/92 (12%)
Laminin_G_2 2616..2755 CDD:280389 36/154 (23%)
Laminin_G_2 2804..2944 CDD:280389 34/144 (24%)
Laminin_G_2 3038..3169 CDD:280389 27/131 (21%)
LamG 3192..3347 CDD:238058
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1836
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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