DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ush2a and bt

DIOPT Version :9

Sequence 1:	NP_067383.3	Gene:	Ush2a / 22283	MGIID:	1341292	Length:	5193	Species:	Mus musculus
Sequence 2:	NP_001162825.1	Gene:	bt / 43814	FlyBaseID:	FBgn0005666	Length:	8933	Species:	Drosophila melanogaster

Alignment Length:	5033	Identity:	986/5033 - (19%)
Similarity:	1595/5033 - (31%)	Gaps:	1743/5033 - (34%)

- Green bases have known domain annotations that are detailed below.

Mouse  1097 EDEHPYYTQYFLDTSLSPHTAYSYYIETSNVHSSTRSI----------PVIYETKPEVSEGHLNL 1151
            |.|.|.:..    |.||..:.|.:.:...|....:..:          |.....||...|
  Fly  2753 EKEPPSFDV----TGLSLGSEYMFRVSAVNEEGESEPLTTLVGVVAKDPFDEPNKPGTPE----- 2808

Mouse  1152 THIIPVGSDSITLTWTGLSNSSD-PVAKYVLSCTPVDST--EPCVSYEGPETSATIWNLVPFTQY 1213
              :....:.||:|.|...:|... |:.||::.....:.|  |..:...|.:..||:..|..:.:|
  Fly  2809 --VTDYDNQSISLKWAAPNNDGGAPIQKYIIEKKNKNKTEWEKALEIPGDQLEATVAGLQEYGEY 2871

Mouse  1214 CFSVQGCTNESCFYSLPIIVTTA-QAPPQTQGPPTVWKISPTELRIEWS---PPVDSNGIIISYE 1274
            .|.|             |.|..| .:||.....|.:.|....:.||:.|   |.:...|..|.|:
  Fly  2872 QFRV-------------IAVNKAGLSPPSDASVPQIVKYKKLKPRIDRSNLKPLLIRAGKPIRYD 2923

Mouse  1275 LYMR-------RWLSTEESLVFESHGLVSSHSALQSVNPSKNLLQQPQASTFISGLEPHTEYAFR 1332
            :.:|       .|...::.|..|.         |.|.:..||:....:.| .|..:..||. .::
  Fly  2924 VNVRGEPAPVITWYQNDKELKPEE---------LPSSSEIKNIPYNTKIS-IIETVRKHTG-IYK 2977

Mouse  1333 VLAVNMAGRVSSAWASERTGESVPVFMAPPS-------VSPLSPHSLSVSWEKPAENFTRGEIIG 1390
            ::|||..|:      .|.|.| |.: :||||       |..::..|..:.|:||.::       |
  Fly  2978 IIAVNEHGQ------DEATVE-VNI-LAPPSKPRGPLDVKDVTKDSCKLKWKKPEDD-------G 3027

Mouse  1391 YKISMVSEHFPLHDVPVMCSKMVHFAKSQ------------DQSYIVRGLEPYRTYSFTVSLCDS 1443
            .|             |:...::..|.|.|            |..:.|:||:....|.|.|...:.
  Fly  3028 GK-------------PISAYQVEKFDKKQGRWVPLGRTSANDTEFDVKGLQEGHEYQFRVKAINE 3079

Mouse  1444 VGCVTSALGSGQTLAA-----APAQLRPPMVTGVNSTTVHIRWLPPAGVNGPP-PLYHLERK--- 1499
            .| .:..|.|..::.|     |.::...|.:...|...|.::|..|....|.| ..|.:|:|
  Fly  3080 EG-ESDPLDSDDSIIAKNPYDAASKPGTPNIVDYNEHMVKLKWEAPRSDGGAPISGYIIEKKDKF 3143

Mouse  1500 ----------KSSLPAATA-AVTKGTRFVGHGYCRFPRTAHADFIGIKASFRTRV--PEGLILLA 1551
                      .:|:|.||. .:.:|..:                     .||.|.  ..|.
  Fly  3144 SPIWDEILSTNTSVPEATVEGLVEGNIY---------------------QFRVRAVNKAGF---- 3183

Mouse  1552 LSPGDQEEYFTLQLKNGRPY---------------------------------FL---------- 1573
            ..|.|..|....:.:|.:||                                 ||
  Fly  3184 SDPSDATEPHLAKPRNLKPYINRDKMKPIKVRAGQPVKFDVDVKGEPAPSLTWFLKETELTSTGQ 3248

Mouse  1574 -------YNSQGTL-------------------------VEVTPTDDPSQG---------YRDG- 1596
                   ||::.||                         |||...|.||:.         :::|
  Fly  3249 VRLENIDYNTKLTLLDTDRKQSGQYKLRAENINGVDEAVVEVIILDKPSKPEGPIEVSDIHKEGC 3313

Mouse  1597 --EWHEIIAVRHQAFGQITLDGQYTGSSSSLNGSSVTGGYTGLFVGGVPQGHSVLQKRLEIIQRG 1659
              :|.     :.:..|.|.:.|.......:..|..|..|             ||..::.:|..:|
  Fly  3314 KLKWR-----KPKDDGGIPITGYVIEKMDTATGKWVPAG-------------SVDPEKYDIEIKG 3360

Mouse  1660 FVGCLKDVFIMKGYSPSGTWLPLDWQSS--------------------EEQVNVHPSWE------ 1698
            .....:..|.:|..:..|...||:.:|:                    .::.:|...||
  Fly  3361 LDPNHRYQFRVKAVNEEGESEPLETESAITAKNPFDVSAPPGLPELEDWDEHHVKLKWEPPIRDG 3425

Mouse  1699 GCP-TN------------------------------LEEGVQFL-------GAGFLELPSD---- 1721
            |.| ||                              ||||.|:.       .||    |||
  Fly  3426 GSPITNYIIEVMDKDSGEFVKAVETDSPVCKGVVKKLEEGQQYKFRVRAVNKAG----PSDPSEQ 3486

Mouse  1722 -TFHAAKD-FEISLKFQTDQLN--------GLLLFIH-NTEGPDFLAVELKRGLLSFKFNSSLVF 1775
             .:|.||. |   ||...|::|        ||.:.:. |..|.....||.      |..|||:..
  Fly  3487 TNWHVAKPRF---LKPHIDRVNLKPVIVKTGLSISLDINIRGEPAPKVEW------FFNNSSVTS 3542

Mouse  1776 TRVDLRLGLADCDGKWNTVSIKKEGS--------------VVSVRVNALKKSTSQAGGQPLLVN- 1825
            ....:::...|.:.|:..:..::..|              ...:.|..|.|.....|  ||.||
  Fly  3543 DEHSVKIDNVDYNTKFFVMRAQRSQSGKYIIKATNEVGEDEAELEVTVLGKPGKPKG--PLQVND 3605

Mouse  1826 -----------SPVYLGGIPRELQDAYRHLTLEPGFRGCVKEVAFARGVVVNLASVSSRAVRVNQ 1879
                       .|...||.|   .|.|....|:|
  Fly  3606 ITKHSCKLKWEKPDDDGGSP---IDYYEIEKLDP------------------------------- 3636

Mouse  1880 DGCLSSDSTVNCGGNDSILVYRGSQQSVYESGLQPFTEYLYRVTASHEGGAVSSDWSRGRTLGTA 1944
                .:...:.||        :.::......||.....|.:||.|.::.|......:....:...
  Fly  3637 ----HTGQWLPCG--------KSTEPEAKVIGLHEGKAYKFRVRAVNKEGESEDLETEKPIIAKN 3689

Mouse  1945 PQSVP-TPSRAQSINGSS--VEVAWNEPAVVKGV-LEKYVLKAYSEDSSQPRVPSASTELHDTST 2005
            |...| .|.:.:..|...  |::||:.|....|. ::|||:: ..:.|.:..|.||:.   ....
  Fly  3690 PYDEPDRPGKPEPTNWDKDFVDLAWDPPKNDGGAPIQKYVIQ-MRDKSGRAWVDSATV---PGDK 3750

Mouse  2006 HSGVLIGLHPFHSYTVTLTACSRAGCTESSQALSISTPQEAPQEVQAPVAVALPNSLSFFWSLPR 2070
            .:|.:.|:...|.|...:.|.::||.::             |.:|...| :|.|..|.     |.
  Fly  3751 CNGTVTGVEEGHEYEFRIVAVNKAGPSD-------------PSDVSKSV-IAKPRFLK-----PH 3796

Mouse  2071 ------QANGIITQYSLYVD--------GRLVYTGKGQNYTVTDLRVFAAYEI------------ 2109
                  |...:.:...|::|        .::.:|     |..|:::.....:|
  Fly  3797 IDRKNLQKKIMRSGQMLHIDALIKAEPPAKVTWT-----YNKTEIKTSDHIKIENEDYKTTFIMP 3856

Mouse  2110 ----------IVGACTQAGCTNSSQVILHTAQLPPEQVDPPGLTVLDSRTIHVRWKQPRQLNG-I 2163
                      ||.|...:| :::.:|.|.....|.:...|..::.:.:.|:|::|::|....| .
  Fly  3857 KVKRADRGIYIVTAKNDSG-SDTVEVELEVLCKPSKPKGPLAVSNVTAETLHLKWEKPEDDGGDP 3920

Mouse  2164 LERYILYILNPIHNSTMWSVVYNSTEKLQAHVLHHLSPGGLYLIRLRVCTGGG----CTTSEPSQ 2224
            :|:|::..::.  .:..|..|. :|:..:|.|. .|:.|..||.|::.....|    ..|..|::
  Fly  3921 IEQYLVERMDT--ETGRWVPVL-TTKTPEADVT-GLTEGKEYLFRVKAVNSEGESEPLVTDIPTK 3981

Mouse  2225 ALMEETIPEGVPAPRAHSYSPDSFNISWTEPEYPNGV-ITTYELYLDD------TLIHNSSGLSC 2282
            |.......:....|:...:|.:..::.|..||...|. ||.|.:...|      .....:|...|
  Fly  3982 AKNPFDAADTPGKPQIVDWSGNHCDLKWRAPEDDGGASITGYIVERKDPNTGKWQKALETSTPDC 4046

Mouse  2283 HAYGFD--PGSLHTFQVQACTAKGCALGPLVGNRTLE----APPE----GVVNVLVKPEGSREAH 2337
            .|...|  .|:.:.|::.|....|.:......::...    |||:    .:.::.:|    ...|
  Fly  4047 KARVNDLIAGNKYQFRIMAVNKAGKSKPSEPSDQMTAKDRFAPPKIDRTNIKDITIK----AGQH 4107

Mouse  2338 VRWD------APA-----HPNGRLTYSVHFTGSFYADQAGDNYTL-LSGTKTIRGIEGSRLWVLV 2390
            :|:|      .||     |...||            :....||.: :...:|       :|.|.:
  Fly  4108 IRFDIKVSGEPPATKVWLHNKARL------------ENDDSNYNIDMESYRT-------KLTVPI 4153

Mouse  2391 DGLVPCSHYMVQVNASNSRGSVLSDPVSVEM----PPGAPDGLLSPRLAAAAPTSLQVVWSTPAR 2451
            ........|.::  |.|..|   .|..|.|:    .||.|:|.|  |:........::.|:.|..
  Fly  4154 SKRFHSGKYTLK--AENESG---RDEASFEVIVLDKPGPPEGPL--RVTDVHKEGCKLKWNAPLD 4211

Mouse  2452 NNAPGSPRYQLQMRPGPSTHGRLELFPIPSASLS---YEVTGLQPFTVYEFRLVATNGFGTAYSA 2513
            :.......|.::.....|  ||.    :||....   .|:..|:|...|:||::|.|..|.:
  Fly  4212 DGGLPIDHYIIEKMDVES--GRW----LPSGRFKESFAELNNLEPSHEYKFRVLAVNTEGES--- 4267

Mouse  2514 WTPLMTTE--------DKPGPIDAPILINVKARMLSVIWRQPAKCNGA-ITHYNI---------Y 2560
             .||...:        |:||....|..::.....:.::||.|....|: ||.|.:         :
  Fly  4268 -EPLTGEQSVIAKNPFDEPGKPGTPEAVDWDKDHVDLVWRPPINDGGSPITGYVVEKREKGTDKW 4331

Mouse  2561 LHG-RLYLTVSGRVTNYTVVPLHPYKAYHFQVEACTSQGCSK-SPSSETVWTLP----------- 2612
            :.| .:.:...|.....||..|:....|.|:|:|..:.|..: |.:|:.:.|.|
  Fly  4332 IKGTEITIPCLGEECKATVPTLNENCEYEFRVKAINAAGPGEPSDASKPIITKPRKLAPKIDRKN 4396

Mouse  2613 --------GNP-------EGIPSPQLFPYTPTSIIVTWQPS---------AHLDLLVENVTI--- 2650
                    |.|       .|.|:|.          |||..:         :|::.|..|...
  Fly  4397 IRTYNFKSGEPIFLDINISGEPAPD----------VTWNQNNKSVQTTSFSHIENLPYNTKYINN 4451

Mouse  2651 --ERRVKGKKEVR--------------NLVT---------------------------------- 2665
              ||:..|..::.              |::|
  Fly  4452 NPERKDTGLYKISAHNFYGQDQVEFQINIITKPGKPEGPLEVSEVHKDGCKLKWKKPKDDGGEPV 4516

Mouse  2666 -----------------LARSQAMKFIDNDPALRPWTRYEYRVLGSTLDGGTNSSAWV------- 2706
                             :.||...::  |...|.|...|::||.....:|.:.....:
  Fly  4517 ESYLVEKFDPDTGIWLPVGRSDGPEY--NVDGLVPGHDYKFRVKAVNKEGESEPLETLGSIIAKD 4579

Mouse  2707 --EVTTRPCRPSGVQPPTVRVLAPDTVEVSWKAPLMQNGD-ILSYEIRMPE---PL-IKMTNMSS 2764
              .|.|:|    ||..||  ....:.||::|..|....|. |..|.:.:.:   || .|....:|
  Fly  4580 PFSVPTKP----GVPEPT--DWTANKVELAWPEPASDGGSPIQGYIVEVKDKYSPLWEKALETNS 4638

Mouse  2765 IMLSHLVKHLIPFTNYSVTIVACSGGNGYLAGCTE-SPPTLATTHPAPPQELAP------LSVIL 2822
            ...:..|:.||....|...:||.:.|     |.:| |.|:...|  |.|:.|||      |..|.
  Fly  4639 PTPTATVQGLIEGNEYQFRVVALNKG-----GLSEPSDPSKIFT--AKPRYLAPKIDRRNLRNIT 4696

Mouse  2823 LSES-----DVGISWQPPSKPNGPNLRYELLRCKIQQPLASNPPEDLNLWHNIYSGTRWFYKD-- 2880
            ||..     |..|:.:|     .|.:.::|....:|.            ..|:...|..:|..
  Fly  4697 LSSGTALKLDANITGEP-----APKVEWKLSNYHLQS------------GKNVTIETPDYYTKLV 4744

Mouse  2881 -KGLSRFTTYEYKLFVHNSVGFTPSREVTVTTLAGSPERGATVTASILNHTAIDVRWKKPTFQDL 2944
             :...|..:.||.:...|:.|........|.|...||..| .:..|.::.....::||:|: .|.
  Fly  4745 IRPTQRSDSGEYLVTATNTSGKDSVLVNVVITDKPSPPNG-PLQISDVHKEGCHLKWKRPS-DDG 4807

Mouse  2945 QGDVEYY--------TLFW-SSGTSEESLKIFPDVDFHVIGQLSPNVEYQVFLLVFNGVHAINST 3000
            ...:||:        |..| .|..|.|     |.||  |.| |||..||:.      .|.|:|:
  Fly  4808 GTPIEYFQIDKLEPETGCWIPSCRSTE-----PQVD--VTG-LSPGNEYKF------RVSAVNA- 4857

Mouse  3001 VVHVTMWEEEPQGMLPPEVVII------------------NSTAVRVIWTSP----SNPNA--VV 3041
                   |.|.|.::..|.::.                  :...|.:.||.|    .:|.:  ::
  Fly  4858 -------EGESQPLVGDESIVARNPFDEPGKPENLKATDWDKDHVDLAWTPPLIDGGSPISCYII 4915

Mouse  3042 TESSVY---------------------VNNKLYK---TGTDAPGSFVLEDLSP------------ 3070
            .:...|                     |..:.||   :..:|.|:....|.:|
  Fly  4916 EKQDKYGKWERALDVPADQCKATIPDLVEGQTYKFRVSAVNAAGTGEPSDSTPPIIAKARNKPPI 4980

Mouse  3071 ----------------FTIYDIQV---------------EVCTKDACVKSNGTQVST-------- 3096
                            || :|.:|               ||.:||. ||......:|
  Fly  4981 IDRSSLVEVRIKAGQSFT-FDCKVSGEPAPQTKWLLKKKEVYSKDN-VKVTNVDYNTKLKVNSAT 5043

Mouse  3097 ---------------AEDTPSDISIPVI------RG------ITSRSLQIDWTTPANPNG----- 3129
                           .||: :|:.:.||      .|      |.|.|..:.|..|.:..|
  Fly  5044 RSDSGIYTVFAENANGEDS-ADVKVTVIDKPAPPNGPLKVDEINSESCTLHWNPPDDDGGQPIDN 5107

Mouse  3130 -IILGYDVLRKTWRPCSETQKLTDKPRDELCKAVKCQYPGKVCGHTCYSPGTKVCCDGLLYDPQP 3193
             ::...|.....|.|..|    ||.|...|          ||.|.|   ||.|.
  Fly  5108 YVVEKLDETTGRWIPAGE----TDGPVTAL----------KVGGLT---PGHKY----------- 5144

Mouse  3194 GYSCCEDKYIALSPNATGVCCGGRMWEAQPDHQCCSGHYARIL---------PGEICCPDERHNR 3249
                   |:...:.|..|.        ::|    .:...|.|.         ||.....|.....
  Fly  5145 -------KFRVRAKNRQGT--------SEP----LTTAQAIIAKNPFDVPTKPGTPTIKDFDKEF 5190

Mouse  3250 VSVGFGDACCGTMPYATSGSQVCCAGRLQDGYRQQCCGGEMVSQDFQCCGGGEEGMVYSYLPGML 3314
            |.:.:      |.|.|..||.:       .||..:  ..:..|.|::.|....:.:..:::|.::
  Fly  5191 VDLEW------TRPEADGGSPI-------TGYVVE--KRDKFSPDWEKCAEISDDITNAHVPDLI 5240

Mouse  3315 CCGQDY------VNMSETICCSASSGESKAHVRKDDPTPVKCCGTELSPESQRCCDGVGYNPLKY 3373
             .|..|      ||.:..   .:.|..::.||.:...||         |:..|          .:
  Fly  5241 -EGLKYEFRVRAVNKAGP---GSPSDATETHVARPKNTP---------PKIDR----------NF 5282

Mouse  3374 VCSDEISAGMAMKETRVCATICPATMKATAHCGRCDFN----------------------ATTHI 3416
            :...:|.||... |..|..|..|...|...|.|....|                      :.|.:
  Fly  5283 MSDIKIKAGNVF-EFDVPVTGEPLPSKDWTHEGNMIINTDRVKISNFDDRTKIRILDAKRSDTGV 5346

Mouse  3417 CTVMRGPLNPTGKKAVE----GLCSAAEEIVHSGDVNTHSFI----------------------- 3454
            .|:....:|.|.:..|:    ...|..|..:.:|||:.:|.:
  Fly  5347 YTLTARNINGTDRHNVKVTILDAPSVPEGPLRNGDVSKNSIVLRWRPPKDDGGSEITHYVVEKMD 5411

Mouse  3455 -------------DRDLKPSTV-----YEYRISAWNSYGRG----FSQSVRAS---TREDVPEGV 3494
                         |.:::...:     |.:|:.|.|..|:.    .||.:.|.   :..|.|...
  Fly  5412 NEAMRWVPVGDCTDTEIRADNLIENHDYSFRVRAVNKQGQSQPLTTSQPITAKDPYSHPDKPGQP 5476

Mouse  3495 KAPRWARTGKHEDVIFLQWEEPMQSNG-PIIHYILFRDGRERF---QGTALSFTD---------T 3546
            :|..|   |||  .:.|:|..|.:..| ||..||:  :.|.:|   :..|:...|         |
  Fly  5477 QATDW---GKH--FVDLEWSTPKRDGGAPISSYII--EKRPKFGQWERAAVVLGDNCKAHVPELT 5534

Mouse  3547 QGIQPLQEYSYQLKACTAAG--------CAVSCK-----------------------------VV 3574
            .|    .||.:::.|....|        ..:.||                             :.
  Fly  5535 NG----GEYEFRVIAVNRGGPSDPSDPSSTIICKPRFLAPFFDKSLLNDITVHAGKRLGWTLPIE 5595

Mouse  3575 AA----------------------------------TTQRSPEN--------------------- 3584
            |:                                  ::.||.|.
  Fly  5596 ASPRPLITWLYNGKEIGSNSRGESGLFQNELTFEIVSSLRSDEGRYTLILKNEHGSFDASAHATV 5660

Mouse  3585 ----VPPP---NITAQSSETLHLSWSVP-------------EKMKDAIKAYQLWLDGKGLIYTDT 3629
                .||.   :||..:.:..||:|:||             ||| |..::  .|.|. |:
  Fly  5661 LDRPSPPKGPLDITKITRDGCHLTWNVPDDDGGSPILHYIIEKM-DLSRS--TWSDA-GM----- 5716

Mouse  3630 SDRRQHTVTGLQPYTNYSFTLAVCTSVGCTSSEPCVGQTLQAA-----------PQGVWVTPRHI 3683
            |....|.||.|.....|.|.:....::|  .|:|     |:|.           |.    .|...
  Fly  5717 STHIVHDVTRLVHRKEYLFRVKAVNAIG--ESDP-----LEAVNTIIAKNEFDEPD----APGKP 5770

Mouse  3684 II---NSTTVELYWNPPERPNGL-ISQY--QLRRNGSLLLVGGR----DNQSFTDSNLEPGSRYI 3738
            ||   :...::|.|..|:...|. ||:|  |.:..||......|    :..:.|...|..|..|.
  Fly  5771 IITDWDRDHIDLQWAVPKSDGGAPISEYIIQKKEKGSPYWTNVRHVPSNKNTTTIPELTEGQEYE 5835

Mouse  3739 YKLEA-RTGGGSSWSE--DYLVQMPLWTPEDIHPPCNVT------VLGSDSIFVAWPTPG----- 3789
            :::.| ...|.|..||  |.::..|.:.|..|..|.|..      :..:|..|:..|.|.
  Fly  5836 FRVIAVNQAGQSEPSEPSDMIMAKPRYLPPKIITPLNEVRIKCGLIFHTDIHFIGEPAPEATWTL 5900

Mouse  3790 NLLPKIPVEYSILLSGGSVTLLVFSVRHRQSAHLKNLSPFTQYEIRIQACQ-----------NGG 3843
            |..|        |||....|  :.|:.|....|..|             ||           ...
  Fly  5901 NSNP--------LLSNDRST--ITSIGHHSVVHTVN-------------CQRSDSGIYHLLLRNS 5942

Mouse  3844 CGVSPGTY---VRTLEAAPVGLMPPLLKALGSSCIEVKWMPPTRPNG--IITSYVVHRRPADTEE 3903
            .|:..|::   |......|.|  |...:.:.::.:.:.|.|| :.||  .|:|||:.:|
  Fly  5943 SGIDEGSFELVVLDRPGPPEG--PMEYEEITANSVTISWKPP-KDNGGSEISSYVIEKR------ 5998

Mouse  3904 ESLLFVWSEGALEFTDDTG------------------TLRPFTLYEYRVRAWNSQGAVDSPWSTI 3950
                        :.|...|                  .|...|:||.||.|.|.||..| |.::.
  Fly  5999 ------------DLTHGGGWVPAVNYVSAKYNHAVVPRLLEGTMYELRVMAENLQGRSD-PLTSD 6050

Mouse  3951 QTLEAPPR----GLPA-PRVQATSAHSAMLNWTEPEAPNGL-ISQYHVIYQERPDAAAPGSSTVH 4009
            |.:.|..:    |.|. |.:..:..:...:.|.:|.:..|. |..|.:   ||.|
  Fly  6051 QPVVAKSQYTVPGAPGKPELTDSDKNHITIKWKQPISNGGSPIIGYDI---ERRD---------- 6102

Mouse  4010 AFTVTGTSRQAHLFGLEPFTT-------------YHIGVVAVNSA--GKVSSPWTLI--KTLESA 4057
                ..|.|...:.| :|..|             |...:.|||:|  ||.|.|..:.  :.|...
  Fly  6103 ----VNTGRWIKING-QPVPTAEYQDDRVTSNHQYQYRISAVNAAGNGKTSEPSAIFNARPLREK 6162

Mouse  4058 PSGLMNFTVEQREKGRALLLQWSEPVKTN---------------GVIKAYNIFNDGV-LEYSGLG 4106
            |....:..:.:|.|.||     .|||..|               |.:|    ..:|. :.|....
  Fly  6163 PRFYFDGLIGKRIKVRA-----GEPVNLNIPISGAPTPTIEWKRGDLK----LEEGKRISYETNS 6218

Mouse  4107 RQFLFR---------------RLAPFTLYTLILEACTTAGCAHSVPQPLWTEEAPPDTQMAPTIQ 4156
            .:.|||               ....|...|..:|...       |.:|     :||:..::.|
  Fly  6219 ERTLFRIDDSNRRDSGKYTVTAANEFGKDTADIEVIV-------VDKP-----SPPEGPLSYT-- 6269

Mouse  4157 SVGPTNVRLHWSQPASPNGKIIHYEVIRRRSEEEDWGNTTWQ-ADG---NTVFTEYNTQGNAWVY 4217
            ...|.::.|||..|....|..|...:|    |..::|...|: ..|   ||.||..|
  Fly  6270 ETAPDHISLHWYSPKDDGGSDITGYII----EFTEFGVDDWKPVPGTCPNTNFTVKN-------- 6322

Mouse  4218 NDTGLQPWRQYAYRICAWNSAGHTCSSWNVVRTLQA----------PPDGLSPPEISYVSMSPLQ 4272
                |...::|.:||.|.|..|.:       ..|:.          ||...|.|.||  :.:|..
  Fly  6323 ----LVEGKKYVFRIRAENIYGAS-------EALEGKPVLAKSPFDPPGAPSQPTIS--AYTPNS 6374

Mouse  4273 LLISWLPPRHSNG-VIQGY---RLQRDGV-LPALNFNASTFSYMDSQLLPFSTYSYAILACT-GG 4331
            ..:.|.||....| .|.||   |.:|.|. :...|:.....||..|.|...:.|.:.:||.. .|
  Fly  6375 ANLEWHPPDDCGGKPITGYIVERRERGGEWIKCNNYPTPNTSYTVSNLRDGARYEFRVLAVNEAG 6439

Mouse  4332 GCCTSEPTNITTPE---VPPSEVSPPVLWDISAHQMNVSWSPPSIPNGKIVKYLLQCDGEEHLAG 4393
            ....|:|::..|.|   ..|....||....|:.:.:.:||.||            :.||:..:.|
  Fly  6440 PGHPSKPSDPMTAEHQRYRPDPPEPPKPDRITRNGVTLSWRPP------------RTDGKSRIKG 6492

Mouse  4394 ---------------------QGLSFLLSNLQPSTQYNISLVACTS-GGCTASRTTSAWTKEAPP 4436
                                 ....:.:.:|:...:|:..:||... |....|:.:...|.|..|
  Fly  6493 YYVEMRPKNGKDWKTVNDIPINSTVYTVPSLKEGEEYSFRVVAENEVGRSDPSKPSQPITIEEQP 6557

Mouse  4437 ENMDPPTLHI---------TGPE-SIEITWTPPRNPHGLIRSYE------------LRRDGAIVY 4479
               :.|.:.:         .|.: ||.:.:.....|:....|.:            |..|.|.|.
  Fly  6558 ---NKPCMELGKVRDIVCRAGDDFSIHVPYLAFPKPNAFWYSNDNMLDDNNRVHKHLTDDAASVV 6619

Mouse  4480 VGLETRYHDFTLAPGVEYSYSVTATNSRGSVLSPL-VKGQTSPSAPSGLQPPKLHSGDALELLAD 4543
            |....|        .....|.:...|:.|...:.: |:....||.|:.|:..:. |||:|.|.
  Fly  6620 VKNSKR--------ADSGQYRLQLKNTSGFDTATINVRVLDRPSPPTRLRADEF-SGDSLTLY-- 6673

Mouse  4544 WDPPVRTNGKII-NYTLFVREMFEGKTRAMSINTTHSSFGT-RSLTVKHLKPFHRYEVRVQACTA 4606
            |:||....|..| ||      :.|.|....|..:..|||.| ..:.:::|.....|:.||.|...
  Fly  6674 WNPPNDDGGSAIQNY------IIEKKEARSSTWSKVSSFCTVPFVRIRNLVLNKEYDFRVIAENK 6732

Mouse  4607 LGCTSSEWTSTQTSEVPPLRQP--------APHLEVQTATGGFQPIVAVWWAGPLQPNGKIICFE 4663
            .|    :.....|||....|.|        .||     .....:..:.:.|..|....|..|...
  Fly  6733 YG----QSDPANTSEPILARHPFDIPNTPGIPH-----GIDSTEDSITIAWTKPKHDGGSPITGY 6788

Mouse  4664 LYRRQVAA---W--------PGTSSSLLIYNGSFRSFMDSELLPFTEYEYQVWAVNSAGKAA--- 4714
            :..:::.:   |        |..|..:            ..|:...|||::|.|||:||::|
  Fly  6789 IIEKRLLSDDKWTKAVHALCPDLSCKI------------PNLIENAEYEFRVAAVNAAGQSAYSG 6841

Mouse  4715 -SNWTRCRTGPAPPE-----GLQAPTFHTVSSTRAVVNISVPSRPNGNISLFRV---------FS 4764
             |:...||..|..|:     .::..|.......|..|......||..:.||..:         |.
  Fly  6842 SSDLIFCRRPPHAPKITSDLSIRDMTVIAGDEFRITVPYHASPRPTASWSLNGLEVIPGERIKFD 6906

Mouse  4765 NSSGTHVTLSEGTATQQTLHDLSPFTTYTIGVEACTCFNCCSRGPTAELRTHPAPPSGLSPPQVQ 4829
            ::....:..::.....:|       .:|||.:                               ..
  Fly  6907 SNDYASMYYNKSAKRDET-------GSYTITL-------------------------------TN 6933

Mouse  4830 TLGSRMASVHWT---PPLLPNGVIHSYEL-----QLQRACPPDSAPRCPPSHTERKYWGPGHRAS 4886
            ..||..||.|.|   .||.|.|.:::|::     .|....|.|.......::...|....|....
  Fly  6934 NKGSDTASCHVTVVDRPLPPQGPLNAYDITPDTCTLAWKTPLDDGGSPITNYVVEKLDNSGSWVK 6998

Mouse  4887 LA-----------GLQPNTAYGVQVVAYNEAG--------STASGWTNFSTKKEMPQYQALFSVD 4932
            ::           ||:|:..|..:|.|.|:.|        ........|:...|..|.:.:....
  Fly  6999 ISSFVRNTHYDVMGLEPHYKYNFRVRAENQYGLSDPLDIIEPIVAKHQFTVPDEPGQPKVIDWDS 7063

Mouse  4933 SNASMVWVD--WSGTFLLNGHLKEY--VVTDGGRRVYSGL--DTTLYIPRMVD-KIFFFQVTCTT 4990
            .|.:::|..  ..|...:.|:..||  ::.|.....|..:  ||...:..::: ..:.|::....
  Fly  7064 GNVTLIWTRPLSDGGSRIQGYQIEYRDILNDSSWNAYDYIIKDTKYQLYNLINGSEYEFRIKAKN 7128

Mouse  4991 DIGSVK--TPLVQYDAATGSGLVLTTPG 5016
            ..|..|  :|.::: ...|...|.:.||
  Fly  7129 AAGLSKPSSPSLRF-KLKGKFTVPSPPG 7155

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ush2a	NP_067383.3	LamGL	145..280	CDD:214722
		Laminin_N	313..513	CDD:295486
		EGF_Lam	514..562	CDD:238012
		EGF_Lam	571..636	CDD:238012
		Laminin_EGF	638..688	CDD:278482
		Laminin_EGF	691..741	CDD:278482
		EGF_Lam	743..788	CDD:238012
		EGF_Lam	792..832	CDD:214543
		Laminin_EGF	844..894	CDD:278482
		EGF_Lam	896..945	CDD:238012
		EGF_Lam	947..997	CDD:238012
		EGF_Lam	998..>1035	CDD:238012
		fn3	1055..1128	CDD:278470	8/30 (27%)
		FN3	1153..1235	CDD:238020	19/84 (23%)
		FN3	1239..1351	CDD:238020	28/121 (23%)
		FN3	1362..1445	CDD:214495	20/101 (20%)
		Laminin_G_2	1539..1669	CDD:280389	34/218 (16%)
		LamG	1707..1857	CDD:238058	44/197 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1931..1955		3/24 (13%)
		FN3	1947..2042	CDD:238020	22/98 (22%)
		FN3	2134..2230	CDD:238020	22/100 (22%)
		FN3	2232..2304	CDD:238020	17/80 (21%)
		FN3	2320..2419	CDD:238020	20/114 (18%)
		FN3	2423..2516	CDD:238020	23/95 (24%)
		FN3	2524..2610	CDD:238020	22/97 (23%)
		FN3	2612..2710	CDD:238020	27/211 (13%)
		FN3	2715..2807	CDD:238020	26/97 (27%)
		FN3	2809..2911	CDD:238020	24/115 (21%)
		FN3	2916..2993	CDD:238020	24/85 (28%)
		FN3	<3441..3486	CDD:238020	13/92 (14%)
		FN3	3582..3668	CDD:238020	27/126 (21%)
		FN3	3672..3753	CDD:238020	22/102 (22%)
		FN3	3769..3854	CDD:238020	21/109 (19%)
		FN3	3867..3952	CDD:238020	24/104 (23%)
		FN3	3956..4053	CDD:238020	25/119 (21%)
		FN3	4153..4239	CDD:238020	24/89 (27%)
		FN3	4260..4343	CDD:238020	25/88 (28%)
		FN3	4348..4431	CDD:238020	17/104 (16%)
		FN3	4435..4519	CDD:238020	17/106 (16%)
		FN3	4521..4619	CDD:238020	29/99 (29%)
		FN3	4645..4722	CDD:238020	20/91 (22%)
		FN3	4724..4800	CDD:238020	14/89 (16%)
		FN3	4817..4918	CDD:238020	25/127 (20%)
		PDZ-binding	5191..5193
bt	NP_001162825.1	I-set	9..101	CDD:254352
		Ig	26..100	CDD:143165
		I-set	119..210	CDD:254352
		Ig	136..209	CDD:143165
		I-set	228..320	CDD:254352
		IGc2	242..312	CDD:197706
		I-set	335..425	CDD:254352
		Ig	350..423	CDD:143165
		Ig	436..530	CDD:299845
		I-set	438..532	CDD:254352
		I-set	545..636	CDD:254352
		Ig	560..633	CDD:143165
		Ig	657..731	CDD:143165
		I-set	746..835	CDD:254352
		Ig	1496..1586	CDD:299845
		IG_like	1503..1588	CDD:214653
		I-set	1639..1724	CDD:254352
		IG	1750..1821	CDD:214652
		IGc2	1750..1806	CDD:197706
		I-set	1826..1909	CDD:254352
		Ig	1831..1897	CDD:299845
		I-set	1914..1998	CDD:254352
		Ig	2020..2095	CDD:299845
		FN3	2100..2194	CDD:238020
		FN3	2203..2292	CDD:238020
		I-set	2311..2395	CDD:254352
		Ig	2321..2395	CDD:299845
		FN3	2399..2493	CDD:238020
		FN3	2501..2590	CDD:238020
		I-set	2602..2693	CDD:254352
		Ig	2619..2693	CDD:299845
		FN3	2697..2793	CDD:238020	8/43 (19%)
		FN3	2801..2893	CDD:238020	25/111 (23%)
		I-set	2902..2995	CDD:254352	27/110 (25%)
		Ig	2919..2993	CDD:299845	21/91 (23%)
		FN3	2999..3088	CDD:238020	22/109 (20%)
		FN3	3102..3191	CDD:238020	21/113 (19%)
		I-set	3208..3292	CDD:254352	9/83 (11%)
		Ig	3219..3292	CDD:299845	9/72 (13%)
		FN3	3296..3390	CDD:238020	20/111 (18%)
		FN3	3400..3489	CDD:238020	17/92 (18%)
		I-set	3494..3590	CDD:254352	19/104 (18%)
		Ig	3516..3590	CDD:299845	12/79 (15%)
		FN3	3594..3682	CDD:238020	22/135 (16%)
		FN3	3694..3781	CDD:238020	23/103 (22%)
		I-set	3795..3885	CDD:254352	14/95 (15%)
		Ig	3813..3885	CDD:299845	12/77 (16%)
		FN3	3889..3980	CDD:238020	21/94 (22%)
		FN3	3990..4082	CDD:238020	18/91 (20%)
		I-set	4090..4181	CDD:254352	22/118 (19%)
		Ig	4108..4181	CDD:299845	19/96 (20%)
		FN3	4185..4271	CDD:238020	24/97 (25%)
		FN3	4285..4383	CDD:238020	22/97 (23%)
		Ig	4404..4480	CDD:299845	14/85 (16%)
		FN3	4484..4571	CDD:238020	9/88 (10%)
		FN3	4584..4677	CDD:238020	28/103 (27%)
		I-set	4685..4775	CDD:254352	19/106 (18%)
		Ig	4703..4775	CDD:299845	14/88 (16%)
		FN3	4779..4863	CDD:238020	30/107 (28%)
		FN3	4879..4970	CDD:238020	13/90 (14%)
		IG	4989..5069	CDD:214652	14/82 (17%)
		Ig	4996..5069	CDD:299845	14/75 (19%)
		FN3	5073..5166	CDD:238020	26/139 (19%)
		FN3	5175..5265	CDD:238020	20/108 (19%)
I-set	5276..5366	CDD:254352	18/100 (18%)
Ig	5293..5366	CDD:299845	13/73 (18%)
FN3	5370..5462	CDD:238020	14/91 (15%)
FN3	5470..5561	CDD:238020	25/101 (25%)
Ig	5559..5654	CDD:299845	6/94 (6%)
I-set	5570..5660	CDD:254352	4/89 (4%)
FN3	5664..5755	CDD:238020	28/106 (26%)
FN3	5764..5853	CDD:238020	24/92 (26%)
I-set	5865..5954	CDD:254352	21/111 (19%)
Ig	5882..5954	CDD:299845	18/94 (19%)
FN3	5958..6049	CDD:238020	27/112 (24%)
FN3	6062..6153	CDD:238020	25/108 (23%)
I-set	6173..6255	CDD:254352	18/90 (20%)
Ig_Titin_like	6182..6255	CDD:143225	13/76 (17%)
FN3	6259..6350	CDD:238020	29/120 (24%)
FN3	6359..6451	CDD:238020	27/93 (29%)
FN3	6470..6552	CDD:238020	14/93 (15%)
I-set	6564..6650	CDD:254352	15/93 (16%)
Ig_Titin_like	6577..6650	CDD:143225	14/80 (18%)
FN3	6654..6745	CDD:238020	32/103 (31%)
FN3	6754..6840	CDD:238020	20/102 (20%)
I-set	6855..6946	CDD:254352	18/128 (14%)
Ig	6874..6946	CDD:299845	16/109 (15%)
FN3	6950..7042	CDD:238020	18/91 (20%)
FN3	7050..7139	CDD:238020	15/88 (17%)
FN3	7151..7237	CDD:238020	2/5 (40%)
I-set	7254..7334	CDD:254352
Ig	7272..7339	CDD:143165
IG_like	7354..7440	CDD:214653
Ig	7366..7440	CDD:299845
FN3	7444..7531	CDD:238020
FN3	7545..7637	CDD:238020
I-set	7648..7737	CDD:254352
Ig	7665..7734	CDD:143165
Ig	7760..7833	CDD:299845
FN3	7837..7927	CDD:238020
STKc_Twitchin_like	7986..8244	CDD:271016
S_TKc	7989..8244	CDD:214567
Ig	8311..8394	CDD:299845
I-set	8312..8401	CDD:254352
I-set	8437..8525	CDD:254352
Ig	8455..8519	CDD:143165
I-set	8632..8721	CDD:254352
IGc2	8646..8711	CDD:197706
I-set	8740..8831	CDD:254352
Ig	8757..8826	CDD:143165
I-set	8839..8922	CDD:254352
Ig	8845..>8909	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000