DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SCUBE3 and scube3

DIOPT Version :9

Sequence 1:	XP_005249000.1	Gene:	SCUBE3 / 222663	HGNCID:	13655	Length:	1009	Species:	Homo sapiens
Sequence 2:	XP_021325384.1	Gene:	scube3 / 100000687	ZFINID:	ZDB-GENE-060717-1	Length:	1019	Species:	Danio rerio

Alignment Length:	1009	Identity:	710/1009 - (70%)
Similarity:	825/1009 - (81%)	Gaps:	21/1009 - (2%)

- Green bases have known domain annotations that are detailed below.

Human    12 LVLLVHARAAQY-SKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGKHCKDVDECE 75
            ||..|...|..: |:..||||||.|..|:|.||||||||.:||||||||||.||||||:|:|||.
Zfish    19 LVAFVQGPAGVFASRNPQDVDECAEALDSCSIDAICQNTLKSYKCICKSGYKGDGKHCEDIDECA 83

Human    76 REDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCRE 140
            .|.|.||||:|:||||||||||||||.|||||||||||||||||||||||.||||||||||.||:
Zfish    84 SEYNGGCVHECINIPGNYRCTCYDGFRLAHDGHNCLDVDECAEGNGGCQQICVNMMGSYECRCRD 148

Human   141 GFFLSDNQHTCIQRPEEGMN-------CMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCK 198
            ||.||||||||||||:...|       ||:|||||||||||||||.|||||||||:||||.||||
Zfish   149 GFLLSDNQHTCIQRPKVRFNGTKDVATCMDKNHGCAHICRETPKGTIACECRPGFQLTKNNRDCK 213

Human   199 LTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIGERRLEQHIP--TQAVSNETCAVNNG 261
            ||||||||||||.|::|:.||:|.||:||.||:|||||: |.|..||.|  .|.:.|||||||||
Zfish   214 LTCNYGNGGCQHICEETDHGPKCSCHMKFALHSDGKTCV-EERSAQHQPLQPQLLPNETCAVNNG 277

Human   262 GCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLL 326
            ||||.||||.|||.|:|||||.|||||||||||||||:|||||||:|||||||||||||||||||
Zfish   278 GCDSTCHDAVTGVRCSCPVGFTLQPDRKTCKDIDECRMNNGGCDHVCRNTVGSFECSCKKGYKLL 342

Human   327 INERNCQDIDECSFDRTCDHICVNTPGSFQCLCHRGYLLYGITHCGDVDECSINRGGCRFGCINT 391
            .|||.|||||||||||.|||.|:|:||||||.||:||:|||:.||||:||||||:|||:.||:||
Zfish   343 TNERTCQDIDECSFDRACDHTCINSPGSFQCYCHKGYVLYGVAHCGDIDECSINQGGCKSGCLNT 407

Human   392 PGSYQCTCPAGQGRLHWNGKDCTEPLKCQGSPGASKAMLSCNRSGKKDTCALTCPSRARFLPESE 456
            .|||:||||.|. :||||.|||.|.:||..:..|.||.|:|:::|||::|:|||.|:|.:|.||:
Zfish   408 LGSYECTCPPGY-KLHWNKKDCVELIKCASNLVAPKATLACSKTGKKESCSLTCASKAHYLSESD 471

Human   457 NGFTVSCGTPSPRAAPARAGHNGNSTNSNHCHEAAVLSIKQRASFKIKDAKCRLHLRNKGKTEEA 521
            :.::||||....|   .::....|:::...|.|..|..:||.|||:||:|||.||.::||:.|:.
Zfish   472 SSYSVSCGISILR---GKSQSRVNTSSIQSCIETQVHPVKQTASFRIKNAKCHLHPKHKGRAEDN 533

Human   522 GRITGPGGAPCSECQVTFIHLKCDSSRKGK-GRRARTPPGKEVTRLTLELEAEVRAEETTASCGL 585
            ||..||||.||:.|.|||::||||||:|.| |||||.|..|||||:||||||||:..:.|.:|.:
Zfish   534 GRQIGPGGQPCNNCLVTFVNLKCDSSKKTKGGRRARNPTNKEVTRITLELEAEVKPGDATGNCNM 598

Human   586 PCLRQRMERRLKGSLKMLRKSINQDRFLLRLAGLDYELAHKPGLVAGERAEPMESCRPGQHRAGT 650
            .|.||.||:::|..:|.|:|||||:|||||:|||:||:|.|    ..:.|...|:|.||:.:...
Zfish   599 MCQRQHMEQQMKTYIKTLKKSINQERFLLRVAGLEYEVAQK----LTQTALKQENCGPGREKDSG 659

Human   651 KCVSCPQGTYYHGQTEQCVPCPAGTFQEREGQLSCDLCPGSDAHGPLGATNVTTCAGQCPPGQHS 715
            :||.|..|:||||:.|:|:.||.||||||||||:||||||.|.|||.||.|:|:||||||||..|
Zfish   660 RCVRCLPGSYYHGEQERCIQCPPGTFQEREGQLACDLCPGGDRHGPQGARNITSCAGQCPPGHFS 724

Human   716 VDGFKPCQPCPRGTYQPEAGRTLCFPCGGGLTTKHEGAISFQDCDTKVQCSPGHYYNTSIHRCIR 780
            .||||||||||.|.|||:.||||||.|||||:||.|||.||.||:.||.||||||||||:|||||
Zfish   725 SDGFKPCQPCPLGKYQPDPGRTLCFSCGGGLSTKREGASSFNDCEVKVLCSPGHYYNTSVHRCIR 789

Human   781 CAMGSYQPDFRQNFCSRCPGNTSTDFDGSTSVAQCKNRQCGGELGEFTGYIESPNYPGNYPAGVE 845
            |..|:||.:||||:|..|||||:|||||:.||:|||||:||||:|||.||||||||||||||.||
Zfish   790 CPHGTYQAEFRQNYCISCPGNTTTDFDGAISVSQCKNRECGGEIGEFIGYIESPNYPGNYPANVE 854

Human   846 CIWNINPPPKRKILIVVPEIFLPSEDECGDVLVMRKNSSPSSITTYETCQTYERPIAFTARSRKL 910
            |:|.||||.||||||||||||||||||||||||||||.|.:||||||||||||||||||||||:|
Zfish   855 CVWTINPPHKRKILIVVPEIFLPSEDECGDVLVMRKNWSATSITTYETCQTYERPIAFTARSRRL 919

Human   911 WINFKTSEANSARGFQIPYVTYDEDYEQLVEDIVRDGRLYASENHQEILKDKKLIKAFFEVLAHP 975
            |||||:::.|||||||||||||||||||||||||||||||||||||||||||||||..|:|||||
Zfish   920 WINFKSNDVNSARGFQIPYVTYDEDYEQLVEDIVRDGRLYASENHQEILKDKKLIKTLFDVLAHP 984

Human   976 QNYFKY-TEKHKEMLPKSFIKLLRSKVSSFLRPY 1008
            .||:|| |....||||:|||:|:.||||:|||||
Zfish   985 HNYYKYSTRDSTEMLPRSFIRLIHSKVSAFLRPY 1018

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCUBE3	XP_005249000.1	EGF_3	33..68	CDD:289699	26/34 (76%)
		FXa_inhibition	76..110	CDD:291342	27/33 (82%)
		FXa_inhibition	116..151	CDD:291342	30/34 (88%)
		FXa_inhibition	161..197	CDD:291342	31/35 (89%)
		FXa_inhibition	201..236	CDD:291342	24/34 (71%)
		FXa_inhibition	256..291	CDD:291342	29/34 (85%)
		FXa_inhibition	297..332	CDD:291342	31/34 (91%)
		vWFA	<329..365	CDD:294047	28/35 (80%)
		EGF_CA	373..414	CDD:214542	28/40 (70%)
		GCC2_GCC3	658..705	CDD:285001	33/46 (72%)
		GCC2_GCC3	712..759	CDD:285001	34/46 (74%)
		GCC2_GCC3	768..815	CDD:285001	33/46 (72%)
		CUB	820..931	CDD:238001	96/110 (87%)
scube3	XP_021325384.1	EGF_3	41..76	CDD:315598	26/34 (76%)
		FXa_inhibition	84..118	CDD:317114	27/33 (82%)
		FXa_inhibition	124..159	CDD:317114	30/34 (88%)
		FXa_inhibition	176..212	CDD:317114	31/35 (89%)
		FXa_inhibition	216..251	CDD:317114	24/34 (71%)
		FXa_inhibition	272..307	CDD:317114	29/34 (85%)
		FXa_inhibition	313..348	CDD:317114	31/34 (91%)
		vWFA	<345..381	CDD:320736	28/35 (80%)
		FXa_inhibition	393..428	CDD:317114	24/35 (69%)
		Ephrin_rec_like	667..714	CDD:311571	33/46 (72%)
		Ephrin_rec_like	721..768	CDD:311571	34/46 (74%)
		Ephrin_rec_like	777..824	CDD:311571	33/46 (72%)
		CUB	829..940	CDD:238001	96/110 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194325004
Domainoid	1	1.000	237	1.000	Domainoid score	I10358
eggNOG	1	0.900	-	-		E33208_3BCPX
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H65059
Inparanoid	1	1.050	1567	1.000	Inparanoid score	I839
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45444
OrthoDB	1	1.010	-	-		D39978at7742
OrthoFinder	1	1.000	-	-		FOG0002948
OrthoInspector	1	1.000	-	-		oto45233
orthoMCL	1	0.900	-	-		OOG6_105735
Panther	1	1.100	-	-	LDO	PTHR24046
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9385
SonicParanoid	1	1.000	-	-		X10751
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	17	17.300