DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nr1h2 and EcR

DIOPT Version :9

Sequence 1:NP_001272446.1 Gene:Nr1h2 / 22260 MGIID:1352463 Length:446 Species:Mus musculus
Sequence 2:NP_001163061.1 Gene:EcR / 35540 FlyBaseID:FBgn0000546 Length:878 Species:Drosophila melanogaster


Alignment Length:473 Identity:168/473 - (35%)
Similarity:250/473 - (52%) Gaps:65/473 - (13%)


- Green bases have known domain annotations that are detailed below.


Mouse    12 VPGNGSPQPSTSATSPTIKEEGQETDPPPGSEGSSSAYIVVILEPEDEPERKRKKGPAPKMLGHE 76
            |.|.|......|.:..:|.....:..|.....|.|:        .|....:|.||||||: :..|
  Fly   207 VGGLGMQHTPRSDSVNSISSGRDDLSPSSSLNGYSA--------NESCDAKKSKKGPAPR-VQEE 262

Mouse    77 LCRVCGDKASGFHYNVLSCEGCKGFFRRSVVHGGAGRYACRGSGTCQMDAFMRRKCQLCRLRKCK 141
            ||.||||:|||:|||.|:||||||||||||.....  |.|:....|:||.:||||||.|||:||.
  Fly   263 LCLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAV--YCCKFGRACEMDMYMRRKCQECRLKKCL 325

Mouse   142 EAGMREQCVLSEEQIRKKRIQKQQQQQPPPPSEPAASSSGRPAASPGTSEASSQGSGEG----EG 202
            ..|||.:||:.|.|...||.:|:.|::    .:...:|   |::..|.:.:.:.|.|:.    |.
  Fly   326 AVGMRPECVVPENQCAMKRREKKAQKE----KDKMTTS---PSSQHGGNGSLASGGGQDFVKKEI 383

Mouse   203 IQLTAAQ-------ELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGA------------DPQSRDA 248
            :.|...:       .|:..:::|   :|..|:.   |.:|...|..            .|...|.
  Fly   384 LDLMTCEPPQHATIPLLPDEILA---KCQARNI---PSLTYNQLAVIYKLIWYQDGYEQPSEEDL 442

Mouse   249 RQ-------------QRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLE 300
            |:             ..|.|.||:.|::||.||:|||.:|.|.::.:||||.||||.:.|:|:|.
  Fly   443 RRIMSQPDENESQTDVSFRHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLR 507

Mouse   301 TARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFS 365
            .||||:|.::.|.|..:.:|::|.:..||: .:.|..:..|.|.|..:.:|:.|||||.||.|||
  Fly   508 MARRYDHSSDSIFFANNRSYTRDSYKMAGM-ADNIEDLLHFCRQMFSMKVDNVEYALLTAIVIFS 571

Mouse   366 ADRPNVQEPSRVEALQQPYVEALLSYTRIKRPQDQLR---FPRMLMKLVSLRTLSSVHSEQVFAL 427
             |||.:::...|||:|..|::.|..|...:...|.:.   :.::|..|..||||.:.::|..|:|
  Fly   572 -DRPGLEKAQLVEAIQSYYIDTLRIYILNRHCGDSMSLVFYAKLLSILTELRTLGNQNAEMCFSL 635

Mouse   428 RLQDKKLPPLLSEIWDVH 445
            :|:::|||..|.||||||
  Fly   636 KLKNRKLPKFLEEIWDVH 653

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nr1h2NP_001272446.1 Transactivation AF-1, required for ligand-independent transactivation function. /evidence=ECO:0000250|UniProtKB:P55055 1..76 16/63 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..69 13/56 (23%)
NR_DBD_like 58..154 CDD:383039 54/95 (57%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 159..201 9/45 (20%)
Transactivation AF-2, required for ligand-dependent transactivation function, mediates interaction with CCAR2. /evidence=ECO:0000250|UniProtKB:P55055 205..446 93/276 (34%)
NR_LBD_LXR 209..444 CDD:132752 89/269 (33%)
EcRNP_001163061.1 NR_DBD_EcR 261..351 CDD:143535 52/91 (57%)
NR_LBD_EcR 420..652 CDD:132736 83/233 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167847954
Domainoid 1 1.000 130 1.000 Domainoid score I5184
eggNOG 1 0.900 - - E33208_3BAC4
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H21397
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1137281at2759
OrthoFinder 1 1.000 - - FOG0005880
OrthoInspector 1 1.000 - - otm43527
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24082
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4552
SonicParanoid 1 1.000 - - X4275
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1211.880

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