Protein Alignment Nr1h3 and EcR

DIOPT Version :9

• Sequence 1: NP_001171201.1
• Gene: Nr1h3 / 22259
• MGIID: 1352462
• Length: 445
• Species: Mus musculus
• Sequence 2: NP_001163061.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Alignment Length: 514
• Identity: 187/514 - (36%)
• Similarity: 260/514 - (50%)
• Gaps: 91/514 - (17%)

Mouse    15 DSATELWKTEP----QDAGDQGGNTC----ILREEARMPQST--------GVALGIGLESAEPTA 63
            :|.|....|.|    |:.|..||...    ||......|...        ||.||:|........
  Fly   147 NSTTPSTPTTPLHLQQNLGGAGGGGIGGMGILHHANGTPNGLIGVVGGGGGVGLGVGGGGVGGLG 211

Mouse    64 L--LPRAETLPEPT----ELRP---------------QKRKKGPAPKMLGNELCSVCGDKASGFH 107
            :  .||::::...:    :|.|               :|.||||||: :..|||.||||:|||:|
  Fly   212 MQHTPRSDSVNSISSGRDDLSPSSSLNGYSANESCDAKKSKKGPAPR-VQEELCLVCGDRASGYH 275

Mouse   108 YNVLSCEGCKGFFRRSVIKGARYVCHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQI 172
            ||.|:||||||||||||.|.|.|.|..|..|.||.|||||||||||:||...|||.|||:.|.|.
  Fly   276 YNALTCEGCKGFFRRSVTKSAVYCCKFGRACEMDMYMRRKCQECRLKKCLAVGMRPECVVPENQC 340

Mouse   173 RLKK--LKRQEEEQAQATSVSPR------------------------VSSPPQ------------ 199
            .:|:  .|.|:|:....||.|.:                        ...|||
  Fly   341 AMKRREKKAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVKKEILDLMTCEPPQHATIPLLPDEIL 405

Mouse   200 ------VLPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPIAPDPQSREARQQRFAHFTEL 258
                  .:|.|:..||.:|.||:..|....:.|..|..|:...|...:.|:    ...|.|.||:
  Fly   406 AKCQARNIPSLTYNQLAVIYKLIWYQDGYEQPSEEDLRRIMSQPDENESQT----DVSFRHITEI 466

Mouse   259 AIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNRED 323
            .|::||.||:|||.||.|.::.:||||.|||..:.|||:|..:|||:..|:||.|..:.||.|:.
  Fly   467 TILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSSDSIFFANNRSYTRDS 531

Mouse   324 FAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALH 388
            :..||: .:.|..:..|.|.|..:::::.|:|||.||.||| |||.::....||.:|..|::.|.
  Fly   532 YKMAGM-ADNIEDLLHFCRQMFSMKVDNVEYALLTAIVIFS-DRPGLEKAQLVEAIQSYYIDTLR 594

Mouse   389 AYVSINHPHDPL---MFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVH 444
            .|:...|..|.:   .:.::|..|..||||.:.::|..|:|:|:::|||..|.||||||
  Fly   595 IYILNRHCGDSMSLVFYAKLLSILTELRTLGNQNAEMCFSLKLKNRKLPKFLEEIWDVH 653

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nr1h3	NP_001171201.1	Transactivation AF-1, required for ligand-independent transactivation function. /evidence=ECO:0000250|UniProtKB:Q13133	1..94		27/115 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..34		7/22 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	63..86		7/43 (16%)
		NR_DBD_LXR	76..176	CDD:143534	64/114 (56%)
		Transactivation AF-2, required for ligand-dependent transactivation function, mediates interaction with CCAR2. /evidence=ECO:0000250|UniProtKB:Q13133	203..445		94/245 (38%)
		NR_LBD_LXR	208..443	CDD:132752	90/237 (38%)
EcR	NP_001163061.1	NR_DBD_EcR	261..351	CDD:143535	57/89 (64%)
		NR_LBD_EcR	420..652	CDD:132736	90/237 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847965
Domainoid	1	1.000	130	1.000	Domainoid score	I5184
eggNOG	1	0.900	-	-		E33208_3BAC4
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5451
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005880
OrthoInspector	1	1.000	-	-		otm43527
orthoMCL	1	0.900	-	-		OOG6_108995
Panther	1	1.100	-	-	LDO	PTHR24082
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4552
SonicParanoid	1	1.000	-	-		X4275
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.720