DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ulk1 and Aduk

DIOPT Version :9

Sequence 1:	XP_011247721.1	Gene:	Ulk1 / 22241	MGIID:	1270126	Length:	1079	Species:	Mus musculus
Sequence 2:	NP_731331.1	Gene:	Aduk / 41112	FlyBaseID:	FBgn0037679	Length:	520	Species:	Drosophila melanogaster

Alignment Length:	292	Identity:	114/292 - (39%)
Similarity:	168/292 - (57%)	Gaps:	32/292 - (10%)

- Green bases have known domain annotations that are detailed below.

Mouse    14 FEFSRKDLIGHGAFAVVFKGRHREVGEAPAEASQSRTPSPRDTLPPKHDLEVAVKCINKKNLAK- 77
            ||...|  :|.|::|.|:|.||:          :.||         .|    |:|.:....|::
  Fly     9 FEILEK--LGAGSYATVYKARHK----------KQRT---------YH----AIKYVEMSTLSQT 48

Mouse    78 SQTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHTMRTLSEDTVRLFLQ 142
            |:..|..||::|:||||:.||.|.||.....::|:|:||||.|:|:.::.|.:.|.|.|.|.||:
  Fly    49 SRENLITEIRLLRELKHKYIVTLQDFFWDDKNIYIVLEYCNAGNLSAFIRTKKALPESTCRYFLR 113

Mouse   143 QIAGAMRLLHSKGIIHRDLKPQNILLSNPGGRRANPSNIRVKIADFGFARYLQSNMMAATLCGSP 207
            |:|.|::.:.:..:.|.||||||:||:    |.||  |:.:|:||||||::|:...:...|.|||
  Fly   114 QLAAAVQYMRANDVSHFDLKPQNLLLT----RGAN--NVSLKVADFGFAQHLKLGEINQQLKGSP 172

Mouse   208 MYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPAIPRETSAP 272
            :|||||::....||.||||||||.|:|:||.||||:.:.:.::|.|...|.:.:........|..
  Fly   173 LYMAPEIVRKHQYDAKADLWSIGVILYECLFGKAPYSSRTIEELLLRIRKAEAITLPPNARISNE 237

Mouse   273 LRQLLLALLQRNHKDRMDFDEFFHHPFLDAST 304
            ...||..||......|:.|.:||.|||||..|
  Fly   238 CHDLLRRLLAHEPTARISFADFFAHPFLDLKT 269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ulk1	XP_011247721.1	PKc_like	13..301	CDD:389743	111/287 (39%)
Ulk1	XP_011247721.1	DUF3543	866..1073	CDD:371876
Aduk	NP_731331.1	S_TKc	9..265	CDD:214567	110/286 (38%)
		PKc_like	13..264	CDD:304357	107/281 (38%)
		MIT_2	274..348	CDD:239147
		MIT	407..472	CDD:282117
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0595
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5656
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840