DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ulk1 and Atg1

DIOPT Version :9

Sequence 1:	XP_011247721.1	Gene:	Ulk1 / 22241	MGIID:	1270126	Length:	1079	Species:	Mus musculus
Sequence 2:	NP_001163433.1	Gene:	Atg1 / 39454	FlyBaseID:	FBgn0260945	Length:	855	Species:	Drosophila melanogaster

Alignment Length:	1127	Identity:	371/1127 - (32%)
Similarity:	487/1127 - (43%)	Gaps:	352/1127 - (31%)

- Green bases have known domain annotations that are detailed below.

Mouse    11 VGKFEFSRKDLIGHGAFAVVFKGRHREVGEAPAEASQSRTPSPRDTLPPKHDLEVAVKCINKKNL 75
            ||::|:|.||::||||||||:|||||:                      || :.||:|||.||..
  Fly     4 VGEYEYSSKDMLGHGAFAVVYKGRHRK----------------------KH-MPVAIKCITKKGQ 45

Mouse    76 AKSQTLLGKEIKILK---ELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHTMRTLSEDTV 137
            .|:|.||||||||||   ||.|||:|||.|.:|..:.|.|||||||||||||||....|||||||
  Fly    46 LKTQNLLGKEIKILKELTELHHENVVALLDCKESQDCVSLVMEYCNGGDLADYLSVKGTLSEDTV 110

Mouse   138 RLFLQQIAGAMRLLHSKGIIHRDLKPQNILLS-NPGGRRANPSNIRVKIADFGFARYLQSNMMAA 201
            ||||.|:||||:.|::|||:|||||||||||| |.|.....||.|.:|||||||||:|....|||
  Fly   111 RLFLVQLAGAMKALYTKGIVHRDLKPQNILLSHNYGKTLPAPSKITLKIADFGFARFLNEGAMAA 175

Mouse   202 TLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPAIP 266
            ||||||||||||||||..||.||||||:||||||||||||||.|.:|.:|:.:||:|..|.|.||
  Fly   176 TLCGSPMYMAPEVIMSLQYDSKADLWSLGTIVYQCLTGKAPFYAQTPNELKSYYEQNANLAPKIP 240

Mouse   267 RETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLD----ASTP------------IKKSPPVPVP 315
            ...|..||.|||.||:||.|||:.::.||.|.||.    |.:|            :.||..:||.
  Fly   241 SGVSPDLRDLLLCLLRRNSKDRISYESFFVHRFLQGKKAAVSPGEPSQAANLRRRVSKSGVLPVD 305

Mouse   316 SYPSSGSGSSSSSSSASHLASPP----SLGEMPQLQK-------------TLTSPADAA-----G 358
            ..|..|:..:.:.|.........    .|.|..|.::             .:.:||..|     |
  Fly   306 MPPLGGTPPAKAKSPLQQQLEQELKLVKLAEQQQKEREEQEAQEDENTVSVVANPAICATITNVG 370

Mouse   359 FLQGSRDSGGSSKDSCDTDDFVMVPAQFPGDLVAEAASAKPPPDSLLCSGSSLVASAGLESHGRT 423
            .|..|.::.||.....|:||||:||...|.|.....|..:..|                .|.|:.
  Fly   371 VLCDSENNSGSCSSHEDSDDFVLVPKNLPEDQRQGLAQVQAQP----------------ASGGQR 419

Mouse   424 PSPSPTCSSSPSPSGRPGPFSSNRYGASVPIPVPTQVHNYQRIEQNLQSPTQQQTARSSAIRRSG 488
            |......||.|.||..|         .|.|.|||              :|.::|.||
  Fly   420 PQQQQNQSSPPRPSSLP---------ISEPKPVP--------------APARRQVAR-------- 453

Mouse   489 STSPLGFGRASPSPPSHTDGAMLARKLSLGGGRPYTPSPQATLFLPVGTIPERPSWSRVPSPQGA 553
                                                |.|     |.|.|:    ...::|..|..
  Fly   454 ------------------------------------PGP-----LTVATL----GGQQIPRSQPI 473

Mouse   554 DVRVGRSPRPGSSVPEHSPRTTGLGCRLHSAPNLSDFHVVRPKLPKPPTDPLGATFSPPQTSAPQ 618
            .|:..|..:..|||.                   ||.:.:.|
  Fly   474 SVKQPRPDQRKSSVS-------------------SDINSISP----------------------- 496

Mouse   619 PCPGLQSCRPLRGSPKLPDFLQRSPLPPILGSPTKAGPSFDFPKTPSSQNLLTLLARQGVVMTPP 683
              |.:|..   .|:|                 ||:.       ::.|..:|..         |||
  Fly   497 --PAVQFA---IGTP-----------------PTRM-------RSASGGSLSE---------TPP 523

Mouse   684 RNRTLPDLSEASPFHGQQLGSGLRPAEDTRGPFGRSFSTSRITDLLLKAAFGTQASDSGSTDSLQ 748
            .:  .|...:.||.|.|             .|..||.::|
  Fly   524 PH--APSTWQVSPGHSQ-------------SPLRRSGNSS------------------------- 548

Mouse   749 EKPMEIAPSAGFGGTLHPGARGGGASSPAPVVFTVGSPPSGATPPQSTRTRMFSVGSSSSLGSTG 813
                .:.|||              |.:..|   |:|||           |.:.:.||..|:||.|
  Fly   549 ----PVLPSA--------------ALTKLP---TLGSP-----------TMLVAPGSLGSIGSAG 581

Mouse   814 SSS----ARHLVPGACGEAPELSAPGHCCSLADPLAANLEGAVTFEAPDLPEETLMEQEHTETLH 874
            |.|    ..|::.......|||.|.|...||.|..|........|:||:|.|||||::||.|||.
  Fly   582 SGSENNNQHHMLGPRAFTLPELGATGGLHSLLDTGAGGGGEPHAFQAPELSEETLMDREHNETLS 646

Mouse   875 SLRFTLAFAQQVLEIA------------ALKGSASEAAGGPEYQLQESVVADQISQLSRE-WGFA 926
            .|.|.||....:.|:|            |...||::||         |..|.||...:.| ...|
  Fly   647 KLNFVLALTDCIQEVADSRCAPLSTFMVAGSQSAAQAA---------SADAQQIPPHAPEHCKRA 702

Mouse   927 EQLVLYLKVAELLSSGLQTAIDQIRAGKLCLSSTVKQVVRRLNELYKASV-----VSCQGLSLRL 986
            |:|||.::..:|||||:..|..|:..|:|..||.||..:..:|..|::.:     ::..||..:.
  Fly   703 ERLVLLVRGLQLLSSGMNLASQQLSNGQLKPSSNVKNALLTMNAKYRSMLFESKRLNGSGLLQKA 767

Mouse   987 QRFFLDKQRLLDGIHGVTAERLILSHAVQMVQSAALDEMFQHREGCVPRYHKALLLLEGLQHTLT 1051
            ..|            .:||::::..:|:.|.|:|||||:.::.:.|..||:.|.:||..|.....
  Fly   768 NAF------------NITADKILYDYALDMCQAAALDELLKNTKNCFERYNTAHILLHSLVQKCN 820

Mouse  1052 DQADIENIAKCKLCIERRLSAL 1073
            ...|...:.|.:..:|:|||.|
  Fly   821 HPQDKMMLNKYRDAVEKRLSIL 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ulk1	XP_011247721.1	PKc_like	13..301	CDD:389743	179/291 (62%)
Ulk1	XP_011247721.1	DUF3543	866..1073	CDD:371876	67/224 (30%)
Atg1	NP_001163433.1	S_TKc	9..274	CDD:214567	177/287 (62%)
		STKc_ULK1_2-like	15..273	CDD:271022	174/280 (62%)
		DUF3543	638..844	CDD:288883	68/226 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834626
Domainoid	1	1.000	347	1.000	Domainoid score	I1031
eggNOG	1	0.900	-	-		E1_KOG0595
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	487	1.000	Inparanoid score	I1410
Isobase	1	0.950	-	0	Normalized mean entropy	S3689
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002616
OrthoInspector	1	1.000	-	-		otm44246
orthoMCL	1	0.900	-	-		OOG6_104561
Panther	1	1.100	-	-	O	PTHR24348
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5656
SonicParanoid	1	1.000	-	-		X1024
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.730