Protein Alignment CDHR3 and cdh-3

DIOPT Version :10

• Sequence 1: NP_689963.2
• Gene: CDHR3 / 222256
• HGNCID: 26308
• Length: 885
• Species: Homo sapiens
• Sequence 2: NP_498687.2
• Gene: cdh-3 / 176085
• WormBaseID: WBGene00000395
• Length: 3361
• Species: Caenorhabditis elegans
• Alignment Length: 917
• Identity: 203/917 - (22%)
• Similarity: 355/917 - (38%)
• Gaps: 218/917 - (23%)

Human    30 NVAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGMEQLDF 94
            |::|.:...|.|.|. |.|.|.|.    |....:..|...  |.::...||.|.     ...|||
 Worm  1563 NISETADRFTEVGKI-VILGAGLE----GSVFRIQDNDYN--FTISPFDGTIFT-----NSPLDF 1615

Human    95 ETGPNIFDLQIYVKDEVGVTDLQVLTVQVTDVN-EPPQF-QGNLAEGLHLYIVERAN----PGFI 153
            |   ||...:..:  ..|.:..||: :.|||.| |.|:| .|::   ::|.::|..:    |..|
 Worm  1616 E---NIKTYRFNI--TAGKSTSQVI-IHVTDENDEAPRFITGDV---VNLKVLEELDTVSYPLII 1671

Human   154 YQVEAFDPEDTSRNIPLSYFLISPPKS-FRM-SANGTLFSTTELDFEAGHRSFH-LIVEVRDSG- 214
            ....|.| .|..:|..::|.::|...| |.: |..|.:.|...||.|  ..|.| |::|.:|:|
 Worm  1672 GSSIAED-LDEGQNGLVTYSILSGNTSLFAVNSTTGDILSLIPLDRE--ESSLHELLIEAKDAGI 1733

Human   215 -GLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITT 278
             .|.|::::.:::.::||..|.|...:....:.|....|:.:..|.|.|.|.:....:.|.|...
 Worm  1734 PSLSATSKILIHVGDINDNTPEFELSSYFIKISENSKIGSKIIRILATDKDKDAELQYSLESNDE 1798

Human   279 VSKYFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPA 343
            ::..|.||..||.|.||.:::|:     :|......|.|.|   |.:.:::.:...|||.|||..
 Worm  1799 ITIPFRINVATGWITVAGKVNRE-----ENEEFRFFVKVTD---GEKSSKVIVEIHVEDFNDNHP 1855

Human   344 TCQKFTFSIMVPERTAKGTLLLDLNKFCFD--DDSEAPNNRFNFTMPSGVGSGSRFLQDPA---- 402
            ........|.||:.|....::..:|....|  |..:...|..|..:..   :|...|:.|.
 Worm  1856 MINDRNSDIFVPDPTRSVEIIHVINVHDLDKSDHLKFSLNNSNLNLSE---NGEITLKSPLQTAV 1917

Human   403 --------GSGKI----------------VLIGDLD-----YENPSNLAA----GN--KYTVIIQ 432
                    .:|.:                |.:..||     ..:...||.    |:  :|:::.:
 Worm  1918 PVRVTVSDDAGHVAFMEYLFHPHSRKHFPVFVEKLDTVSVREHDEQELAVFKANGDSIRYSIVSR 1982

Human   433 VQD-----------------VAPPYYKNNVYVYILTSPENEFPLI------------------FD 462
            ..|                 .|..|.:..|::...|..:|: ||.                  ||
 Worm  1983 CSDHLEMEKSTGILKTKSSLDAEEYSECLVFIIATTYFDNK-PLSTITKATIKIVDINDNSPRFD 2046

Human   463 RPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKV 527
            :..|.|:|:|....:. :|.|.|.|.| ..|.:.|.|..|.|:.::     :..::|:::.|..:
 Worm  2047 QQLYRFNVTENSGPKL-IGHVIARDID-RSSRVFYEIVGGDANHEF-----MVTESGQIESVRDL 2104

Human   528 DCETTPIYILRIQATNN---EDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFK 589
            |.||...|.|.::|.::   ....:.||.|.:|:|:|..|..: ..:.:.:|.|:::|..:  .:
 Worm  2105 DRETKSEYHLIVEAIDDGKPRRRGNTTVIVTVLDEDDNAPRFS-RIFHVEVPEDVRIGEPV--IQ 2166

Human   590 LTCTDLDSSPRSFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTD 654
            |:.:|.|.. .:.|:.:..|.....|....|.|    .:.:....|    |:|...|::.|.:||
 Worm  2167 LSASDADEH-SNHRFELDGGGEGIPFRVDENTG----MVFVNDSLD----FEKKQSYRIKVKLTD 2222

Human   655 DNLMSDRKKAEALVETGTVTLSIK-------VIPHPTTIITTTPRPRVTYQV------------L 700
                     ...|:|| ::.:::|       :...|..:..:........|.            :
 Worm  2223 ---------GAWLIET-SLFVNVKDVNDNAPIFEKPEYLFISEENSAEIGQFHASDMDSENNGKI 2277

Human   701 RKNVYSPSAWYVPFVITLGSIL------LLGLLV----YLVVLLAKAIHRHCPCKT--GKNKE-- 751
            |.:|.||.....|....|....      |:.|.|    :.|..|.|.:..|...|:  ||.|:
 Worm  2278 RYSVTSPYFKIEPSTGVLSRFRQQLPQPLMSLKVTATDHGVPRLQKTVLAHLVDKSSFGKIKQRR 2342

Human   752 --PLTKKGE------------------TKTAERDVVVE-------TIQMNTIFD---GEAIDPVT 786
              ..||.|:                  |.|.:.|||::       .::.:||::   .:|::...
 Worm  2343 IRETTKVGDVIGKKIDSGATIFPLDVATVTRDGDVVLKKNATQFWILENDTIYEFVKTDAMESTK 2407

Human   787 GETYEFN 793
            .|....|
 Worm  2408 NENITLN 2414

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDHR3	NP_689963.2	Cadherin_repeat	26..128	CDD:206637	28/98 (29%)
		Cadherin_repeat	141..231	CDD:206637	26/98 (27%)
		Cadherin_repeat	242..341	CDD:206637	26/98 (27%)
		Cadherin_repeat	465..561	CDD:206637	27/98 (28%)
		Cadherin_repeat	570..679	CDD:206637	22/115 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	808..885
cdh-3	NP_498687.2	Cadherin_repeat	31..113	CDD:206637
		Cadherin_repeat	121..225	CDD:206637
		Cadherin_repeat	242..326	CDD:206637
		Cadherin_repeat	448..529	CDD:206637
		Cadherin_repeat	637..734	CDD:206637
		Cadherin_repeat	1116..1184	CDD:206637
		Cadherin_repeat	1285..1364	CDD:206637
		Cadherin_repeat	1559..1643	CDD:206637	27/97 (28%)
		Cadherin_repeat	1671..1752	CDD:206637	24/83 (29%)
		Cadherin_repeat	1760..1853	CDD:206637	26/100 (26%)
		CA	1975..2043	CDD:214520	9/68 (13%)
		Cadherin_repeat	2050..2142	CDD:206637	27/98 (28%)
		Cadherin_repeat	2149..2241	CDD:206637	22/112 (20%)
		Cadherin_repeat	2250..2329	CDD:206637	13/78 (17%)
		LamG	3082..3201	CDD:214598