Protein Alignment Ubr1 and Ubr1

DIOPT Version :9

• Sequence 1: NP_033487.2
• Gene: Ubr1 / 22222
• MGIID: 1277977
• Length: 1757
• Species: Mus musculus
• Sequence 2: NP_001245723.1
• Gene: Ubr1 / 32687
• FlyBaseID: FBgn0030809
• Length: 1824
• Species: Drosophila melanogaster
• Alignment Length: 1928
• Identity: 613/1928 - (31%)
• Similarity: 928/1928 - (48%)
• Gaps: 286/1928 - (14%)

Mouse     6 MDGAERMDVSPEPPLAPQRPASWW----------------------DQQVDFYT-AFLHHLAQLV 47
            ||..:..||...||.....|...|                      .:..|:.| |.:.....:.
  Fly     1 MDRYDMEDVVVAPPAECSSPLKEWRLKRQAGTLDRSDIIEFLKRESPKYFDYQTSATVKDTNVIT 65

Mouse    48 PEIYFAEMDPDLEKQEESVQMSILTPLEWYLFGEDPDICLEKLKHSG-AFQLCGKVFKSGETTYS 111
            .:..|.|   .|.|:|      |:..:..::.|::|...||||:..| ...:||||||:||.|||
  Fly    66 LKCMFKE---SLAKEE------IIDVVVEFMLGDNPSSALEKLRLEGNTATVCGKVFKNGEPTYS 121

Mouse   112 CRDCAIDPTCVLCMDCFQSSVHKNHRYKMHTSTGGGFCDCGDTEAWKTGPFCVDHEPGRAGTTKE 176
            ||:|.:|||||||::||:.|.|:.|:|||.||.|||.|||||.||||...:|..|...|....:.
  Fly   122 CRECGVDPTCVLCVNCFKRSAHRFHKYKMSTSGGGGCCDCGDDEAWKKDQYCELHLANRKNPLES 186

Mouse   177 SLHCPLNEEVIAQARRIFPSVIKYIVEMTIWEEEKELPP--ELQIREKN--------ERYYCVLF 231
            .:   |.:.|:.:....|.:::.:.|...      |:.|  .||..:.|        .:|..||:
  Fly   187 KI---LTDAVLERVEICFGAILAFCVSYL------EIEPNASLQCLDGNVEGGQVDGAQYCTVLY 242

Mouse   232 NDEHHSYDHVIYSLQRALDCELAEAQLHTTAIDKEGRRAVKAGVYATCQEAKEDIKSH------- 289
            |||.|::|.||.:|.:...|...:|.....|||:|||..||...:..|.:.|..|::.
  Fly   243 NDESHTFDQVIQTLTKIAKCRAKDAMEIVAAIDREGRAVVKCDTFEECNKLKVSIENQMILPTSL 307

Mouse   290 -SENVSQHPLHVEVLHSVVMAHQKFALRLGSWMNKIMSYSSDFRQIFCQACLVEEPGSENPCLIS 353
             |...:...|...|||...:|.|:|||:|..|..:.:.....||:.|.:  ||:.. .|..| |.
  Fly   308 VSTARNNQSLRTSVLHIGAVACQQFALQLLGWFQEFLVRHYLFRKTFSE--LVQRK-QETFC-IR 368

Mouse   354 RLMLWDAKLYKGARKILHELIFSSFFMEMEYKKLFAMEFVKYYKQLQKEYISDDHERSISITALS 418
            .::.:|.||:|.||...|.|:.|...||.:.|.:.|.||.:.|..:.:::|||||:.:.||.:||
  Fly   369 HILEYDVKLWKTARTCWHRLLISGMLMEYDNKMILAQEFSRRYATIVEDFISDDHDHAFSIVSLS 433

Mouse   419 VQMLTVPTLARHLIEEQNVISVITETLLEVLPEYLDRNNKFNFQG--YSQDKLGRVYAVICDLKY 481
            ||:.|||::|.|||..:.:...:..|...|..|...||...:|..  .|.....|...::.||:|
  Fly   434 VQLFTVPSIAHHLIAHEGIFDKLLHTFYHVAIEKFIRNKTLHFSKNIASLTFFKRANYILYDLRY 498

Mouse   482 ILISKPVIWTERLRAQFLEGFRSFLKILTCMQGMEEIRRQVGQHIEVDPDWEAAIAIQMQLKNIL 546
            :|..||.:.:..||..||||.|:.:::|..|||||.:.||.|||::.:|:||.|..:.::|...:
  Fly   499 LLSLKPDVLSNDLRNGFLEGCRALMRVLNVMQGMESMTRQTGQHMDYEPEWECAFNLHIKLATTI 563

Mouse   547 LMFQEWCACDEDLLLVAYKECHKAVMRCSTNFMSSTKTVVQ---LCGHSLETKSYKVSEDLVSIH 608
            ....:|.:.|..||...||...:|::  |.:|:...:.|:|   :..|......|.:|...||||
  Fly   564 SQVIDWASGDVKLLRKLYKMTMRALV--SNSFIVGGEKVMQPKKVADHVANCLVYDISVQPVSIH 626

Mouse   609 LPLSRTLAGLHVRLSRLGAISRLHEFVPFDGFQVEV-----------LVEYPLRCL-VLVAQVVA 661
            |||||..||:::   .|||    |: :.:||.|.|.           ::| |:.|. .::|||.|
  Fly   627 LPLSRFFAGIYL---HLGA----HD-LTYDGLQTETEALSIKLTPREIIE-PVLCTQAMIAQVGA 682

Mouse   662 EMWRRNGLSLISQVFYYQDVKCREEMYDKDIIMLQIGASIMDPNKFLLLVLQRYE----LTDAFN 722
            .:|||||.:|:.|:::|::|:||.||.|:||..||||||:|:.|:||:.||.|:.    |.:.:.
  Fly   683 GLWRRNGYTLLHQLYFYRNVRCRVEMLDRDIACLQIGASLMESNEFLIHVLNRFNTIPWLQENYW 747

Mouse   723 KTISTKD--QDLIKQYNTLIEEMLQVLIYIVGERYVPGVGNVTREEVIMREITHLLCIEPMPHSA 785
            ..:|..:  .|:|:: .::.:|.|::||.|:|||::|||..||.|:.:.:||..||||:|..||.
  Fly   748 SLLSGNEMNDDIIRE-ASIFDEFLELLIVIIGERWMPGVSMVTEEDRLRKEIIQLLCIKPYSHSE 811

Mouse   786 IARNLPENE--NNETGLENVINKVATFKKP-GVSGHGVYELKDESLKDFNMYFYHYSKTQHSKAE 847
            ::|.||:..  |::...|.|||.||.|||| |....||||||:..||:||||||||:|...||||
  Fly   812 LSRALPDGNSGNSDNVFEEVINTVAVFKKPVGADSKGVYELKEHLLKEFNMYFYHYTKEDKSKAE 876

Mouse   848 HMQKKRRKQENKDEALPPPPPPEFCPAFSKVVNLLSCDVMMYILRTIFERAVDMESNLWTEGMLQ 912
            .:|::|||.:.:....|||..|:..|||:.:.|:|.|.|.:.|...|.|||::..|..:||..||
  Fly   877 ELQRERRKAKKQLVCCPPPMLPKLTPAFTPMANILQCPVFLNICSLIMERALNAYSRSFTESHLQ 941

Mouse   913 MAFHILALGLLEEKQQLQKAPEEEVAFDFYHKASRLGSSAMNAQNIQMLLEKLKGI---PQLESQ 974
            ...|:|...:.||      ..|......||.::...|           :||||:.:   |:||:.
  Fly   942 KVLHLLGYAIQEE------LSEHYPFLSFYERSQEYG-----------ILEKLEELARCPRLEAH 989

Mouse   975 KDMITWILQMFDTVKRLREK----------SCLVVATTSGLECVKSEEITHDKEKAERKRKAEAA 1029
            .|.:.|.::.|   |:|:.|          ||.... |.|...:.:||    :.:.||:.:|..|
  Fly   990 YDFVLWTIERF---KQLQAKQAPSDGRAGPSCSQQG-TGGKLSLSAEE----QAREERENRARLA 1046

Mouse  1030 RLHRQKIMAQMSALQKNFIETHKLMYDNTSEVTGKE---------DSIMEEESTSAVSEASRIA- 1084
            ...|..|||||...||:||.::..|:.:|...|.||         :.|..||...||:..|::|
  Fly  1047 AERRAHIMAQMQKAQKSFISSNAEMFADTENETRKESASTGPMDWEDIPPEEEQGAVALESKVAC 1111

Mouse  1085 LGPKRGPAVTEKEVLTCILCQEEQEVKLENNAMVLSACVQKSTALTQHRGKPVDHLGETLDPLFM 1149
            |||.|.......:...||||.|...:......:|.||.||.|..                  :|.
  Fly  1112 LGPDRKFYHGTDDTFKCILCFENCAISRGGRQLVSSAFVQTSRV------------------IFT 1158

Mouse  1150 DPDLAH---GTYTGSCGHVMHAVCWQKYF---EAVQLSSQQRIHVDLFDLESGEYLCPLCKSLCN 1208
            .|:|.:   ..:...||||||..||.:||   |..:|....|....|....:.|:.||.|::|.|
  Fly  1159 TPNLRNSQSALHISCCGHVMHYSCWLEYFTNEEFKELRRPHRNRAALAQAANVEFQCPYCRTLSN 1223

Mouse  1209 TVIPIIPLQP--QKINSENAEALAQLLTLARWIQTVLARISGYNIK-HAKGEAPAVP-VLFNQGM 1269
            .:||:....|  ....|.| |:...|.:....:.|:...:.  |:| |.....|:|. :|...|:
  Fly  1224 AIIPVTETLPAFSAPPSPN-ESYLPLDSFVEIMSTLAIELG--NVKDHELTTLPSVSNILRLSGV 1285

Mouse  1270 --GDSTFE-----------FHSILSFGVQSSVKYSNSIKEMVILFATTIYRIGLK-VPPDELDPR 1320
              |.:.||           .|:....|::...|        .:|....|.:..|| .|..|....
  Fly  1286 VGGLAQFERSVQLIKNPPRLHADYIEGIEFLKK--------ALLNTMKIQQSHLKDHPAIESIEM 1342

Mouse  1321 VPMMTWSTCAFTIQAIENLLGDEGKPLFGALQNRQHNGLKALMQ-----FAVAQRTTCPQVLIHK 1380
            ||:: |.:|::|:||:|..|....|||...|..|..:..:.|::     .|:...|..|.:...:
  Fly  1343 VPIL-WDSCSYTLQALEIYLYAVEKPLKAELSMRHQSCARNLVRACSRSSALEWETDLPLLPPMR 1406

Mouse  1381 HLARLLSVILPNLQSENTPGLLSVDLFHVLV----GAV-LAFPSLYWDDTVDLQPSPLSSSYNHL 1440
            ..|...|.:|..:.::|...:|..|.|.|||    |.: |..|...:...:     |..|.:: .
  Fly  1407 SQAEFSSRLLDTIFNQNDTSVLEWDCFRVLVPFQFGVLNLMVPEKGYKTII-----PSGSMFD-F 1465

Mouse  1441 YLFHLITMAHMLQILLTTDTDLSSGPPLAEGEEDSEEARCASAFFVE------------------ 1487
            |:...:.:|.:.:.:|..|.:...    |:..|.:..:......::|
  Fly  1466 YIMQTMFLAQLTKAVLCFDVEKEK----AKRAEKAPNSELTQLDYIEQLPSRIRDNMIDFYRRYN 1526

Mouse  1488 --------------VSQHTDGLAGCG------APGWYLWLSL---RNGITPYLRCAALLFHYLLG 1529
                          |.:.::...|.|      ....:|.|.|   :..::.:|||:.|.:.:|..
  Fly  1527 IPARVLQKTKQKQLVEEESEENQGHGQTVVIPCESHHLALLLEYVQRQMSSFLRCSCLFYRFLTD 1591

Mouse  1530 VAPPEELFANSAEGEFSALCSYLSLPTNLFLLFQEYWDTI-RPLLQRWCGDPALLKSLKQKSAVV 1593
            |..| :.|.......|..:|.||.|...|.:.|.  .:|: ..::..:...|.:.:.::|:.
  Fly  1592 VDFP-DTFPTDQPDRFDLMCQYLGLDPMLGVYFD--METVYATMMHSFASHPHIDREVEQRC--- 1650

Mouse  1594 RYPRKRNSL-IE-----LP------EDYSCLLNQASHFRCPRSADDERKHPVLCLFCGAILCSQN 1646
             .|..|.|| :|     ||      :|:|.|:|..|...||.:..:|.|.|.:||.||.|||.|:
  Fly  1651 -QPDARRSLQVEPCLRPLPRLKVLCDDFSDLINSVSDIFCPNNEREEMKTPTMCLICGLILCGQS 1714

Mouse  1647 ICCQEIVNGEEVGACVFHALHCGAGVCIFLKIRECRVVLVEGKARGCAYPAPYLDEYGETDPGLK 1711
            .|||..:....||||..||..|||.|.|||:||:|:||.: |:.:||..|.||||||||||.||:
  Fly  1715 YCCQPELGKVSVGACTHHAHACGAEVGIFLRIRDCQVVYL-GRGKGCFVPPPYLDEYGETDMGLR 1778

Mouse  1712 RGNPLHLSRERYRKLHLVWQQHCIIEEIARSQETNQMLFGFNW 1754
            |||||.||:..|||::|.|..|.:..||||..:...:.....|
  Fly  1779 RGNPLRLSQAAYRKIYLQWLGHGLHGEIARLNDNANVAAAAQW 1821

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ubr1	NP_033487.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..24		6/17 (35%)
		zf-UBR	99..166	CDD:280386	44/66 (67%)
		ClpS	221..301	CDD:280736	27/95 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	842..868		11/25 (44%)
Ubr1	NP_001245723.1	zf-UBR	109..176	CDD:280386	33/66 (50%)
		ClpS	236..301	CDD:280736	21/72 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839988
Domainoid	1	1.000	738	1.000	Domainoid score	I99
eggNOG	1	0.900	-	-		E1_KOG1140
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	911	1.000	Inparanoid score	I367
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59210
OrthoDB	1	1.010	-	-		D34639at33208
OrthoFinder	1	1.000	-	-		FOG0001341
OrthoInspector	1	1.000	-	-		otm43776
orthoMCL	1	0.900	-	-		OOG6_101603
Panther	1	1.100	-	-	LDO	PTHR21497
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1593
SonicParanoid	1	1.000	-	-		X1260
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.800