DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SDK1 and DIP-epsilon

DIOPT Version :9

Sequence 1:	NP_689957.3	Gene:	SDK1 / 221935	HGNCID:	19307	Length:	2213	Species:	Homo sapiens
Sequence 2:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster

Alignment Length:	536	Identity:	112/536 - (20%)
Similarity:	183/536 - (34%)	Gaps:	153/536 - (28%)

- Green bases have known domain annotations that are detailed below.

Human   258 AYYVQAVNEKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARP- 321
            ||:::|:         |.|:::.:...:.:...:: |.....||...|.||   ||..:.|..|
  Fly     2 AYHLEAI---------SSFLYVGLGCLIASSVALS-TDTGSEGNAGNVGGS---TLNNVISEDPE 53

Human   322 ----VEDLSVTWKRN-------------------------------------GVRITSGLHSFGR 345
                :|:::|...||                                     .:.:|...|...|
  Fly    54 FTDVIENITVPAGRNVKLACSVKNLGSYKVAWMHFEQSAILTVHNHVITRNPRISVTHDKHDKHR 118

Human   346 R--LTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPPYF-TAEPESRISAEVEETVDIG 407
            .  |.|:|....|.|.|:|:.    :.........|:.::.||.. .|...|.|.....:.|.:.
  Fly   119 TWFLHINNVQEEDRGRYMCQI----NTVTAKTQYGFVKVVVPPNIDDALTSSDIIVREGDNVTLR 179

Human   408 CQAMGVPLPTLQWYKD---AISISRLQNPRYKV--LASGGLRIQKLRPEDSGIFQCFASNEGGEI 467
            |:|.|.|.||::|.:|   .|.|    |...:|  |.:..|.::::.....|.:.|.|||
  Fly   180 CKAKGSPEPTIKWKRDDGNKIVI----NKTLEVHDLETDSLELERISRLHMGAYLCIASN----- 235

Human   468 QTHTYLDVTNIAPVFTQR---PVDTT-----------VTDGMTAILRCEVSGAPKPAITWKRENH 518
                     .:.|..::|   .||.:           :..|....|.|.:...|.....|.|||.
  Fly   236 ---------GVPPSVSKRIKVSVDFSPMVWIPHQLVGIPIGFNITLECFIEANPTSLNYWTREND 291

Human   519 ILASGSVR-----IPRFMLLESG-GLQIAPVFIQDAGNYTCYAANTEGSLNASATLTVWNRTSIV 577
            .:.:.|.:     ||.....::. .|.|..|...|.|||.|.|.|..|.::.:..|.:.:..:..
  Fly   292 QMITESSKYKTETIPGHPSYKATMRLTITNVQSSDYGNYKCVAKNPRGDMDGNIKLYMSSPPTTQ 356

Human   578 HPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDI 642
            .||        ||.||....|....::|      |....||.:.:.|               |.:
  Fly   357 PPP--------TTTTLRRTTTTAAEIAL------DGYINTPLNGNGI---------------GIV 392

Human   643 GDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVS-----------PNSSHSHAVVLSWVRPFDG 696
            |:.....|...|..|......:.|:..|.|.|..|           .:.||.:.:..||
  Fly   393 GEGPTNSVIASGKSSIKYLSNLNEIDKSKQKLTGSSPKGFDWSKGKSSGSHGNLMASSW------ 451

Human   697 NSPILYYIVELSENNS 712
              |::..|:.|...:|
  Fly   452 --PLICCILALLTTHS 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SDK1	NP_689957.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..73
		I-set	104..188	CDD:254352
		Ig	122..176	CDD:143165
		Ig	219..265	CDD:299845	3/6 (50%)
		IGc2	312..364	CDD:197706	18/95 (19%)
		I-set	386..475	CDD:254352	24/94 (26%)
		Ig	404..472	CDD:143165	20/72 (28%)
		I-set	480..570	CDD:254352	27/109 (25%)
		Ig	494..570	CDD:299845	23/81 (28%)
		I-set	575..664	CDD:254352	17/88 (19%)
		Ig	580..664	CDD:299845	16/83 (19%)
		FN3	668..759	CDD:238020	12/56 (21%)
		fn3	771..857	CDD:278470
		FN3	872..967	CDD:238020
		FN3	972..1054	CDD:238020
		FN3	1070..1166	CDD:238020
		FN3	1176..1271	CDD:238020
		fn3	1279..1365	CDD:278470
		FN3	1378..1471	CDD:238020
		FN3	1477..1572	CDD:238020
		FN3	1580..1694	CDD:238020
		FN3	1704..1797	CDD:238020
		FN3	1802..1883	CDD:238020
		FN3	1903..1996	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2075..2098
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q6V4S5	2207..2213
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	15/99 (15%)
		Ig	69..139	CDD:143165	10/69 (14%)
		IG_like	165..249	CDD:214653	24/101 (24%)
		IGc2	172..237	CDD:197706	20/82 (24%)
		IG_like	267..348	CDD:214653	22/80 (28%)
		Ig	270..339	CDD:299845	20/68 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810