Protein Alignment SDK1 and sdk1a

DIOPT Version :10

• Sequence 1: NP_689957.3
• Gene: SDK1 / 221935
• HGNCID: 19307
• Length: 2213
• Species: Homo sapiens
• Sequence 2: XP_009297968.2
• Gene: sdk1a / 558391
• ZFINID: ZDB-GENE-081104-374
• Length: 2246
• Species: Danio rerio
• Alignment Length: 2248
• Identity: 1495/2248 - (66%)
• Similarity: 1807/2248 - (80%)
• Gaps: 54/2248 - (2%)

Human    15 GGAEPPERAGPG-RPRGSPPGRARPSLAPR-------PGPEPSRPRAAPETSGG----------- 60
            ||.|..||..|| ..:..|.||...:|...       .|.:.||...|...|..
Zfish     4 GGCEATERQFPGLSKKRRPAGRHNTALKEEEEEDSVYSGGDRSRKDTARSRSTALLTRVDKNAIM 68

Human    61 -DTAGAG--------RCGGRRAAKLGPGRR-------GWWALLALQLHLLRALAQDDVAPYFKTE 109
             |...|.        |..||..:  |.|:|       .|||...||:|:|.|:.|.|||||||||
Zfish    69 CDLKSASSSSSMIFTRFSGRNFS--GNGKRKFAVRTWSWWAFFCLQVHVLEAVTQGDVAPYFKTE 131

Human   110 PGLPQIHLEGNRLVLTCLAEGSWPLEFKWMRDDSELTTYSSEYKYIIPSLQKLDAGFYRCVVRNR 174
            ||.|:|||||||||:|||||||||||||||.:::::|.:|.||||.|.|||:.:.|.|:||||||
Zfish   132 PGPPEIHLEGNRLVMTCLAEGSWPLEFKWMLNNTDITAFSPEYKYTISSLQRSNMGVYQCVVRNR 196

Human   175 MGALLQRKSEVQVAYMGSFMDTDQRKTVSQGRAAILNLLPITSYPRPQVTWFREGHKIIPSNRIA 239
            ||||||:|:|:||||||.|:|.||||||:||||||||...::.:|||||||||:|:|||||||||
Zfish   197 MGALLQKKAEIQVAYMGDFIDNDQRKTVTQGRAAILNSPAVSCFPRPQVTWFRDGYKIIPSNRIA 261

Human   240 ITLENQLVILATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIA--------RDVGTP-ETMAPTI 295
            ||||||||:|||..||||.|||||||||||||||||.|:|::|        .|...| :.:||.|
Zfish   262 ITLENQLVVLATAASDAGRYYVQAVNEKNGENKTSPSIYLNVAANKKYRGSHDSEAPADPVAPVI 326

Human   296 VVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKRNGVRITSGLHSFGRRLTISNPTSADTGPY 360
            |:||.|.:||||.||.||||:|:|||||.||:.|:||||.:.||:.||.|||||.||||.|.|.|
Zfish   327 VIPPRNTTVVAGISEATLECVANARPVEKLSLVWRRNGVEVASGVGSFSRRLTIINPTSTDVGMY 391

Human   361 VCEAALPGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAI 425
            ||||.|..|:.:||.|.|||.|.|.|||||||..::..|||::|||.|||.|||:|.|:|||||:
Zfish   392 VCEALLLDSSVKPAEARAFLSITEAPYFTAEPRRKMMGEVEKSVDIQCQARGVPMPKLEWYKDAV 456

Human   426 SISRLQNPRYKVLASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTT 490
            .:|:|.|||||:::|.||:::||:|.|:|||||||.|..||.|.|||||||::||.||..|:|.|
Zfish   457 PLSKLNNPRYKIISSMGLQVRKLQPSDAGIFQCFARNSAGEAQVHTYLDVTSMAPAFTAPPLDIT 521

Human   491 VTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYA 555
            ||||..|...|.|||||||||.|:|:..|||||||:||||.|||||||||.||.:||.|||||||
Zfish   522 VTDGAVAAFTCRVSGAPKPAIVWRRDTQILASGSVQIPRFTLLESGGLQIQPVVLQDTGNYTCYA 586

Human   556 ANTEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSS 620
            ||:||::||||:||||:||||..||.|..|||||||.|.|||||||||.:|||||||...::.|.
Zfish   587 ANSEGAINASASLTVWSRTSISSPPTDRRVIKGTTAILECGATHDPRVGVRYVWKKDEELVSHSR 651

Human   621 TSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVSPNSSHSHA 685
            ..||.:: :|||.||||||||||:|:|:::||.||:|:.||||||||||||:||..|.|::.|.:
Zfish   652 GGRISLQ-EGSLHISQTWSGDIGNYTCDVISEAGNESKEARLEVIELPHSPRNLQASLNANDSRS 715

Human   686 VVLSWVRPFDGNSPILYYIVELSENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVG 750
            |.|||:||||||||:|:|:||||||||||:|:||:|.|..||..|.||||||:|||||||||:||
Zfish   716 VDLSWMRPFDGNSPLLHYVVELSENNSPWRVYLSDVDPSGTGAMVKGLTPARSYQFRVCAVNQVG 780

Human   751 RGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPG 815
            |||||.||:||||.||||||||||||||||||||||||||||||.:.|||||||:||||||||||
Zfish   781 RGQYSTETNRLMLREEPPSAPPKNIVASGRTNQSIMVQWQPPPEPQLNGVLRGYVLRYRLAGLPG 845

Human   816 EYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEA 880
            ||||:||:|||:||||:|:||||||||||||||.||||||||:.|||||||||||||||.|:.:|
Zfish   846 EYQQKNISSPEINYCLITELIIWTQYEIQVAAYTGAGLGVFSQPVTEYTLQGVPTAPPQGVEAKA 910

Human   881 VNSTTIQFLWNPPPQQFINGINQGYKLLAWPADAPEAVTVVTIAPDFHGVHH-GHITNLKKFTAY 944
            ||||||:|.||||||||||||||||||:|||..:||.|.||||.||:||..| |:|:.|:||:.|
Zfish   911 VNSTTIEFSWNPPPQQFINGINQGYKLMAWPERSPEEVIVVTITPDYHGTRHLGYISGLRKFSWY 975

Human   945 FTSVLCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISW 1009
            .||||||||||:||.|.|:||.|.||.||.||.|||||||||||||||:||::||||||||.:||
Zfish   976 LTSVLCFTTPGNGPRSAPKLVQTFEDIPGPVGRLSFTEILDTSLKVSWEEPVDKNGIITGYLVSW 1040

Human  1010 EVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPS 1074
            ||.|.|.||:...|.:||.:||:.||:||||||::|||:|..|.|.||||||||||||:|||.||
Zfish  1041 EVQGNNQSRVARNLANTTLDYKVTGLTSLTTYTLEVAAMTEAGVGTVTSSTISSGVPPELPGPPS 1105

Human  1075 NLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLT 1139
            |||||.||.|||||:||.|.||||:||:||||||||:||::|||..|||:||:|:|||||:||||
Zfish  1106 NLVISKISSRSATLKFRAGDDGKTAISKWIVEGQVGSIGEDEEWKVLYEKENDPEAQMLEVPNLT 1170

Human  1140 PYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDSQYNG 1204
            |:|||||||:||||||||..|..|||||||||||||||:||||||||||||.|||||||:|:|||
Zfish  1171 PFTHYRFRMRQVNIVGPSAVSVPSRVIQTLQAPPDVAPSSVTVRTASETSLWLRWVPLPESEYNG 1235

Human  1205 NPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRG 1269
            ||||||||::..|:||:..|..::::||||||.|:|.||||.||:||:||||::|.|||||.|:|
Zfish  1236 NPESVGYRVRVMRADLRGEASTRLLNDRLEREITLEGLEEWTEYQLQIQAFNSIGPGPWSESVKG 1300

Human  1270 RTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNH 1334
            ||||||||.|||||:|||:||::||:||..|||.:|||.|||||:||:.||.|.|.:.::|:||.
Zfish  1301 RTRESVPSGAPENVTAEAMSSSRILVTWGPVPEHEQNGNILGYKVLFKEKDSDSEAQVNVVKGNL 1365

Human  1335 TQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQ 1399
            |||.||..|||:|.||:|||||||||:|..|.|.:|||||||.||||:||||||||||.||:|||
Zfish  1366 TQSVLLRNLRKYVQYEIQVLAFTRIGDGQLSNPPVLERTKDDVPGPPMRLVFPEVRLTEVRVVWQ 1430

Human  1400 PPEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPL 1464
            ||.:|||||:|||:||||.|..|:.|.|:|||...|||||:.|.||||||||:||||.||||.|.
Zfish  1431 PPVDPNGIIMGYQVAYRLDSGDPNQFITIEVGPDTRQFTASSLTPESAYIFRISAKTEQGWGSPA 1495

Human  1465 EATVITTEKRERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYSS 1529
            :|.|||||.||||.|||:|.|||..|.:|.|.|.||||.||:||:||||:|.:|||.|||..:||
Zfish  1496 QAVVITTEIRERPQPPRQLRVPQDHVQSRKLLLNWVPGGDGSSPVRYFTLQTQELPSGEWIPHSS 1560

Human  1530 SISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSS 1594
            :|||..::..||||:||||||||:.||||:|||.:|.||:|:|||||||.|.|...|..|.||:|
Zfish  1561 AISHNYSSWEVDRLKPFTSYKLRMMATNDVGDSKYSQETDAITTLQDVPDEAPMIQSVKPSTTTS 1625

Human  1595 VLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTS 1659
            ||:|||.|::||:||:|.|||:|||||:|:: :..::|...|...|..||||:|:.|||::.|.
Zfish  1626 VLVQWQTPKEESVNGVLVGYRLYYRELQYDS-TPQDSKRPVNSSQLRTELTAKSTVKTVSNPSL- 1688

Human  1660 TMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDP 1724
            |..|||.|:||||||::|||||:|||||.|||||||||||||::||||:|:..|:::||||.|:|
Zfish  1689 TEFELTQLQKYRRYEIVMTAYNVIGESPPSAPVEVFVGEAAPSVAPQNIQINTLSSTQLEVQWEP 1753

Human  1725 PPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPK 1789
            ||.|:|||.||||||.|||.|||||||::|:||.||..:|||||||:|.|:|.:.|||||||||.
Zfish  1754 PPAETQNGIIQGYKILYWEMDSQNETERVKILFRPETNMRLKNLTSYTYYMVKLLAFNAAGDGPF 1818

Human  1790 SDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQGVSKVVTV 1854
            |:|::|||.||||.||||::|||:||:|||||||.|.:.||:::||||||||.||:|||:|||||
Zfish  1819 SEPRRGRTLQAAPSAPSFISFSEVTSSTLNVSWGFPLSPNGVVEGYRVVYEPTAPIQGVTKVVTV 1883

Human  1855 EVRGNWQRWLKVRDLTKGVTYFFRVQARTITYGPELQANITAGPAEGSPGSPRDVLVTKSASELT 1919
            ::||:|||||||||||||:||.|||||:||.||||.:|||||||.:||||||.::.:||:.|.|.
Zfish  1884 DIRGSWQRWLKVRDLTKGMTYCFRVQAKTIAYGPEAEANITAGPVKGSPGSPVEMSITKTGSMLN 1948

Human  1920 LQWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVAVNEA 1984
            :|||.|.:|....||||||||||||||||.||:.:|.::||:::|||:||||::|:|||:||||.
Zfish  1949 IQWTAGETGAGHVTGYVIEARPSDEGLWDTFVRHLPPTSTSHSVSLDRLRQGISYQFRVLAVNEF 2013

Human  1985 GYGEPSNPSTAVSAQVEAPFYEEWWFLLVMALSSLIVILLVVFALVLHGQNKKYKNCSTGKGIST 2049
            ||||||.||.|:||||:.|||||||||:|:||..||::|||||.|||||||:|||:|.|||.:||
Zfish  2014 GYGEPSAPSAAMSAQVDTPFYEEWWFLIVLALCGLILLLLVVFGLVLHGQNRKYKSCGTGKAVST 2078

Human  2050 MEESVTLDNGGFAALELSSRHLNVKSTFSKKNGTRSPPRPSPGGLHYSDEDICNKYNGAVLTESV 2114
            :||:||||||||.||||:||.::||..|.:||||||||||:|.||.|||||||:.|||.|.|||.
Zfish  2079 VEETVTLDNGGFTALELNSRPVHVKGVFLRKNGTRSPPRPNPAGLRYSDEDICSNYNGVVSTEST 2143

Human  2115 SLKEKSADASESEATDSDYEDALPKHSFVNHYMSDPTYYNSWKRRAQG-RAPAPHRYEAVAGSEA 2178
            :|.|:.|:.||||||||:.|:...||||||||||||:|:|||||:.:| :......||..|..:.
Zfish  2144 ALTERPAEMSESEATDSECEEEPIKHSFVNHYMSDPSYFNSWKRQQKGLKQTLACSYEECASGDN 2208

Human  2179 GAQLHPVITTQSAGGVYTPAG---PGARTPLTGFSSFV 2213
            .:....|:|..|.||||||||   ||:|||:|||||||
Zfish  2209 ESYYQTVVTQHSVGGVYTPAGQPAPGSRTPVTGFSSFV 2246

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SDK1	NP_689957.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..73		21/85 (25%)
		PHA03247	<2..80	CDD:223021	22/92 (24%)
		Ig_3	104..173	CDD:464046	48/68 (71%)
		Ig	193..274	CDD:472250	64/80 (80%)
		Ig strand B	208..212	CDD:409353	3/3 (100%)
		Ig strand C	222..226	CDD:409353	3/3 (100%)
		Ig strand E	245..248	CDD:409353	2/2 (100%)
		Ig strand F	258..263	CDD:409353	3/4 (75%)
		Ig_3	293..364	CDD:464046	47/70 (67%)
		Ig	386..475	CDD:472250	55/88 (63%)
		Ig strand B	404..408	CDD:409353	3/3 (100%)
		Ig strand C	417..421	CDD:409353	1/3 (33%)
		Ig strand E	441..445	CDD:409353	2/3 (67%)
		Ig strand F	455..460	CDD:409353	4/4 (100%)
		Ig strand G	468..471	CDD:409353	1/2 (50%)
		I-set	480..570	CDD:400151	63/89 (71%)
		Ig strand B	497..501	CDD:409353	1/3 (33%)
		Ig strand C	510..514	CDD:409353	2/3 (67%)
		Ig strand E	536..540	CDD:409353	3/3 (100%)
		Ig strand F	550..555	CDD:409353	4/4 (100%)
		Ig strand G	563..566	CDD:409353	2/2 (100%)
		FN3	<607..1053	CDD:442628	325/446 (73%)
		FN3	668..759	CDD:238020	64/90 (71%)
		FN3	<937..>1204	CDD:442628	198/266 (74%)
		fn3	1176..1264	CDD:394996	60/87 (69%)
		FN3	<1251..1595	CDD:442628	229/343 (67%)
		FN3	1378..1471	CDD:238020	66/92 (72%)
		FN3	<1522..1906	CDD:442628	254/383 (66%)
		FN3	1903..1996	CDD:238020	57/92 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2075..2098		15/22 (68%)
		PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5	2207..2213		5/5 (100%)
sdk1a	XP_009297968.2	None