DRSC/TRiP Functional Genomics Resources

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Protein Alignment SDK1 and dpr3

DIOPT Version :9

Sequence 1:NP_689957.3 Gene:SDK1 / 221935 HGNCID:19307 Length:2213 Species:Homo sapiens
Sequence 2:NP_001014459.2 Gene:dpr3 / 3346208 FlyBaseID:FBgn0053516 Length:522 Species:Drosophila melanogaster


Alignment Length:357 Identity:71/357 - (19%)
Similarity:115/357 - (32%) Gaps:125/357 - (35%)


- Green bases have known domain annotations that are detailed below.


Human   416 PTLQWYKDAISISRLQNPRYKVLASGGLRIQKLRPEDSGIFQCFASNEG--GEIQTHTY------ 472
            |||..:   :|.|:.|:|.....::..        .....|..||...|  .|...||:      
  Fly   147 PTLSTF---LSSSQSQSPSPPAASASA--------SSPSSFSSFAVAHGPQTEATNHTFKSLAFL 200

Human   473 ----------------------------LDVTNIAPVFT-QRPVDTTVTDGMT-AILRCEVSGAP 507
                                        .|.:...|:|. ..|.:.|...|.| ||::|.|....
  Fly   201 DASFGSDLFAQTDAKRERSGAADEESQDADTSQSLPIFDFGMPRNITGRTGHTEAIIKCRVDSLH 265

Human   508 KPAITW--KRENHILASGSVRI---PRFMLLESGG-----LQIAPVFIQDAGNYTCYAANTEGSL 562
            ..:::|  ||:.|||..|:...   .||.:.||..     |.:.....:|:|.|.| ..|||..:
  Fly   266 DKSVSWIRKRDLHILTVGTATYTSDKRFQVTESKDSREWTLHVKAPLAKDSGIYEC-QVNTEPKM 329

Human   563 NASATLTVWN-----RTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYV----WKKDNVALTP 618
            :.:..|.:..     :..|..||:.|.. .|:...|:| ....|  |::.:    |.:....:||
  Fly   330 SMAFQLNIIEISPDAKAVISGPPDLHFK-AGSAIILNC-LVQQP--SVKDIGPIYWYRGEHMITP 390

Human   619 ------------------------SSTSRIVVEKD--------------------GSLLISQTWS 639
                                    :|.:.|:.|.|                    ..|.||...:
  Fly   391 FDADDGQPEIPAGRGEHPQGIPEDTSPNDIMSEVDLQMEFATRIAMESQLGDTLKSRLRISNAQT 455

Human   640 GDIGDYSCEIVSEGG--------NDSRMARLE 663
            .|.|:|:|:..:...        ||...|.::
  Fly   456 TDTGNYTCQPTTASSASVLVHVINDENPAAMQ 487

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SDK1NP_689957.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..73
I-set 104..188 CDD:254352
Ig 122..176 CDD:143165
Ig 219..265 CDD:299845
IGc2 312..364 CDD:197706
I-set 386..475 CDD:254352 14/94 (15%)
Ig 404..472 CDD:143165 13/57 (23%)
I-set 480..570 CDD:254352 30/101 (30%)
Ig 494..570 CDD:299845 26/86 (30%)
I-set 575..664 CDD:254352 26/145 (18%)
Ig 580..664 CDD:299845 24/140 (17%)
FN3 668..759 CDD:238020
fn3 771..857 CDD:278470
FN3 872..967 CDD:238020
FN3 972..1054 CDD:238020
FN3 1070..1166 CDD:238020
FN3 1176..1271 CDD:238020
fn3 1279..1365 CDD:278470
FN3 1378..1471 CDD:238020
FN3 1477..1572 CDD:238020
FN3 1580..1694 CDD:238020
FN3 1704..1797 CDD:238020
FN3 1802..1883 CDD:238020
FN3 1903..1996 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2075..2098
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2207..2213
dpr3NP_001014459.2 Ig 243..330 CDD:299845 27/87 (31%)
IG_like 243..329 CDD:214653 27/86 (31%)
Ig 350..464 CDD:299845 21/117 (18%)
IG_like <441..477 CDD:214653 7/35 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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